140 research outputs found
Objectivity in law
No full textThe question of objectivity in legal interpretation has emerged in recent years as a highly important topic in contemporary jurisprudence. This original book addresses the issue of how and in what sense legal interpretation can be objective. The author supports the possibility of objectivity in law and spells out the content of objectivity involved. He then provides a comprehensive defence against the classical, as well as less well-known, objections to the possibility of objectivity in legal interpretationThe discussion is firmly grounded in metaphysics, which sets the book apart from other similar discussions in jurisprudence. Stavropoulos identifies an important source of resistance to acceptance of the possibility of objectivity in legal interpretation: a widely-held but faulty semantic. He then develops an alternative semantic framework which draws on influential theories in contemporary philosophy. The book shows that objectivism is a natural, commonsensical position, and rejects the currently popular notion that objectivism requires extravagant or bizarre metaphysics. Furthermore, the discussion presents the opportunity to reinterpret major debates in jurisprudence and to show how influential theories, notably H. L. A. Hart's and Ronald Dworkin's, bear on that central issu
Η ΙΑΤΡΟΪΣΤΟΡΙΚΗ ΣΚΕΨΗ ΤΟΥ ΑΡΙΣΤΟΤΕΛΗ Κ. ΣΤΑΥΡΟΠΟΥΛΟΥ (1927-1994)
No full textΔεν παρατίθεται περίληψη στα Ελληνικά.In this paper the author presents Ar. Stavropoulos' views and theoretical approach to the history of Medicine and his contribution to the study of the history of that discipline in Greece during the period of Turkish occupation and in the 19th century, as reflected in his work. Aspects such as, the influence of epidemics on the Greek population economy and demography, the function of hospitals, health policy, medical training and the formation of the medical personnel, feature among the topics discussed by Stavropoulos, in this context
Avoidant romantic attachment in adolescence: Gender, excessive internet use and romantic relationship engagement effects
No full textRomantic development is a distinctive characteristic of puberty. However, a significant proportion of adolescents present with avoidant romantic attachment (ARA) tendencies, which have significant impact on their general adaptation. ARA variations have been suggested in relation to age, gender, engagement with a romantic partner and Excessive Internet Use (EIU) behaviours. In this longitudinal, two-wave study of a normative sample of 515 Greek adolescents at 16 and 18 years, ARA was assessed with the relevant subscale of the Experiences in Close Relationships-Revised and EIU with the Internet Addiction Test. A three-level hierarchical linear model found ARA tendencies to decrease between 16 and 18 while engagement in a romantic relationship and EIU were associated with lower and higher ARA tendencies respectively. Gender did not differentiate ARA severity either at the age of 16 or its changes over time. Results highlight the need of adopting a longitudinal-contextualized approach and provide implications for prevention and intervention initiatives in relation to the romantic development of adolescents. © 2018 Stavropoulos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Inside the intimate zone: The case of aural micro-space in multichannel compositional practice
No full textThis paper aims to present the notion of aural microspace, an area whose aural architecture is not accessible unless it is mediated by recording technology and discuss the exploration of this concept in compositional practice. The author analyses the characteristics of acoustic space from a spectromorphological, cultural and technical perspective, with a focus on auditory intimacy and is proposing novel ways for working in this domain with references to two multichannel acousmatic works, Topophilia and Karst Grotto
Evaluation of Ligand-Inducible Expression Systems for Conditional Neuronal Manipulations of Sleep in Drosophila
No full textDrosophila melanogaster is a powerful model organism for dissecting the molecular mechanisms that regulate sleep, and numerous studies in the fly have identified genes that impact sleep–wake cycles. Conditional genetic analysis is essential to distinguish the mechanisms by which these genes impact sleep: some genes might exert their effects developmentally, for instance by directing the assembly of neuronal circuits that regulate sleep; other genes may regulate sleep in adulthood; and yet other genes might influence sleep by both developmental and adult mechanisms. Here we have assessed two ligand-inducible expression systems, Geneswitch and the Q-system, for conditional and neuronally restricted manipulations of sleep in Drosophila. While adult-specific induction of a neuronally expressed Geneswitch transgene (elav-GS) is compatible with studies of sleep as shown previously, developmental induction of elav-GS strongly and nonspecifically perturbs sleep in adults. The alterations of sleep in elav-GS animals occur at low doses of Geneswitch agonist and in the presence of transgenes unrelated to sleep, such as UAS-CD8-GFP. Furthermore, developmental elav-GS induction is toxic and reduces brood size, indicating multiple adverse effects of neuronal Geneswitch activation. In contrast, the transgenes and ligand of the Q-system do not significantly impact sleep–wake cycles when used for constitutive, developmental, or adult-specific neuronal induction. The nonspecific effects of developmental elav-GS activation on sleep indicate that such manipulations require cautious interpretation, and suggest that the Q-system or other strategies may be more suitable for conditional genetic analysis of sleep and other behaviors in Drosophila
Resonance and the Underlying Coherent Structures in Supersonic Round Twin Jets
No full textEmitted from aircraft travelling at supersonic speeds, screech tones are high-amplitude, discrete-frequency, and can damage the surrounding aircraft structure. To mitigate their impacts, a better understanding of how they arise is required. This thesis models the screech tones present in aircraft with a round twin-exhaust configuration. New insights into their generation, and the behaviours of the components generating them, are presented. In particular for low supersonic velocities, and as the two round exhausts are brought closer together
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Objectivity in law /
No full textThis treatise addresses a central topic in contemporary jurisprudence, namely whether it is possible for legal interpretations to be objective. The author claims that objectivity is possible in law, offering arguments based on metaphysics, philosophy and meta-ethics to reinforce his theory
A Hilbert space extremum problem with application to multiple objective control system design
No full textConvex alternating projection algorithms (CAP) can be applied to solve multiple objective and hierarchical optimization problems in the area of control systems design involving both the ℋ2 and the ℋ∞ norms. The paper presents an application of a CAP algorithm for solving a simple problem in this area. This relies on the solution of an extremum problem in Hilbert space used to calculate a required projection onto a closed convex set. © The author 2012
insomniac and Cullin-3 Regulate Sleep and Wakefulness in Drosophila
No full textSummaryIn a forward genetic screen in Drosophila, we have isolated insomniac, a mutant that severely reduces the duration and consolidation of sleep. Anatomically restricted genetic manipulations indicate that insomniac functions within neurons to regulate sleep. insomniac expression does not oscillate in a circadian manner, and conversely, the circadian clock is intact in insomniac mutants, suggesting that insomniac regulates sleep by pathways distinct from the circadian clock. The protein encoded by insomniac is a member of the BTB/POZ superfamily, which includes many proteins that function as adaptors for the Cullin-3 (Cul3) ubiquitin ligase complex. We show that Insomniac can physically associate with Cul3, and that reduction of Cul3 activity in neurons recapitulates the insomniac phenotype. The extensive evolutionary conservation of insomniac and Cul3 suggests that protein degradation pathways may have a general role in governing the sleep and wakefulness of animals
A software estimation process in project management
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