481 research outputs found
'Les Perses de l'Occident' de Sotiris Skipis: Une invasion barbare en Europe dans les années 1920
No full textThe study examines the contribution of Sotiris Skipis (1881-1952) to theatrical art, an aspect which has been neglected by contemporary research. It focuses on an almost unknown three-act drama of Skipis, which the present research retrieved from the rare collections of Greek libraries: Les Perses de l' Occident (The Persians of the West). The author published the work in Paris in 1917, before the bloodshed of World War I was beginning to wane, to openly condemn pan-Germanism and racism, even before the latter term prevailed. The paper explores the ideological, aesthetic, and dramaturgical substratum of the text reflecting the spread of racial theories in Europe is explored. It also interprets the reasons that did not allow for the stage realization of the play on Parisian stages at the time of publication, despite the warm praise from Parisian scholarship, and that it took more than a century to pull the play out of oblivion
Supplemental Material, ECMO_manuscript_supplementary_JICM - Extracorporeal Membrane Oxygenation in Pregnant and Postpartum Women: A Systematic Review and Meta-Regression Analysis
No full textSupplemental Material, ECMO_manuscript_supplementary_JICM for Extracorporeal Membrane Oxygenation in Pregnant and Postpartum Women: A Systematic Review and Meta-Regression Analysis by John J. Y. Zhang, Jamie Ann-Hui Ong, Nicholas L. Syn, Roberto Lorusso, Chuen Seng Tan, Graeme MacLaren and Kollengode Ramanathan in Journal of Intensive Care Medicine</p
sj-docx-2-eso-10.1177_23969873231151262 – Supplemental material for Distal medium vessel occlusions in acute ischaemic stroke – Stent retriever versus direct aspiration: A systematic review and meta-analysis
No full textSupplemental material, sj-docx-2-eso-10.1177_23969873231151262 for Distal medium vessel occlusions in acute ischaemic stroke – Stent retriever versus direct aspiration: A systematic review and meta-analysis by Keith Zhi Xian Toh, Ming Yi Koh, Enver De Wei Loh, Gabriel Yi Ren Kwok, Yao Hao Teo, Yao Neng Teo, Claire Xin Yi Goh, Nicholas Li Xun Syn, Andrew Fu Wah Ho, Ching-Hui Sia, Patrick A Brouwer, Tommy Andersson, Lukas Meyer, Jens Fiehler, Pervinder Bhogal, Vijay K Sharma, Benjamin YQ Tan and Leonard L L Yeo in European Stroke Journal</p
sj-docx-1-eso-10.1177_23969873231151262 – Supplemental material for Distal medium vessel occlusions in acute ischaemic stroke – Stent retriever versus direct aspiration: A systematic review and meta-analysis
No full textSupplemental material, sj-docx-1-eso-10.1177_23969873231151262 for Distal medium vessel occlusions in acute ischaemic stroke – Stent retriever versus direct aspiration: A systematic review and meta-analysis by Keith Zhi Xian Toh, Ming Yi Koh, Enver De Wei Loh, Gabriel Yi Ren Kwok, Yao Hao Teo, Yao Neng Teo, Claire Xin Yi Goh, Nicholas Li Xun Syn, Andrew Fu Wah Ho, Ching-Hui Sia, Patrick A Brouwer, Tommy Andersson, Lukas Meyer, Jens Fiehler, Pervinder Bhogal, Vijay K Sharma, Benjamin YQ Tan and Leonard L L Yeo in European Stroke Journal</p
sj-docx-3-eso-10.1177_23969873231151262 – Supplemental material for Distal medium vessel occlusions in acute ischaemic stroke – Stent retriever versus direct aspiration: A systematic review and meta-analysis
No full textSupplemental material, sj-docx-3-eso-10.1177_23969873231151262 for Distal medium vessel occlusions in acute ischaemic stroke – Stent retriever versus direct aspiration: A systematic review and meta-analysis by Keith Zhi Xian Toh, Ming Yi Koh, Enver De Wei Loh, Gabriel Yi Ren Kwok, Yao Hao Teo, Yao Neng Teo, Claire Xin Yi Goh, Nicholas Li Xun Syn, Andrew Fu Wah Ho, Ching-Hui Sia, Patrick A Brouwer, Tommy Andersson, Lukas Meyer, Jens Fiehler, Pervinder Bhogal, Vijay K Sharma, Benjamin YQ Tan and Leonard L L Yeo in European Stroke Journal</p
Syntaxin-3 Binds and Regulates Both R- and L-Type Calcium Channels in Insulin-Secreting INS-1 832/13 Cells.
No full textSyntaxin (Syn)-1A mediates exocytosis of predocked insulin-containing secretory granules (SGs) during first-phase glucose-stimulated insulin secretion (GSIS) in part via its interaction with plasma membrane (PM)-bound L-type voltage-gated calcium channels (Cav). In contrast, Syn-3 mediates exocytosis of newcomer SGs that accounts for second-phase GSIS. We now hypothesize that the newcomer SG Syn-3 preferentially binds and modulates R-type Cav opening, which was postulated to mediate second-phase GSIS. Indeed, glucose-stimulation of pancreatic islet β-cell line INS-1 induced a predominant increase in interaction between Syn-3 and Cavα1 pore-forming subunits of R-type Cav2.3 and to lesser extent L-type Cavs, while confirming the preferential interactions between Syn-1A with L-type (Cav1.2, Cav1.3) Cavs. Consistently, direct binding studies employing heterologous HEK cells confirmed that Syn-3 preferentially binds Cav2.3, whereas Syn-1A prefers L-type Cavs. We then used siRNA knockdown (KD) of Syn-3 in INS-1 to study the endogenous modulatory actions of Syn-3 on Cav channels. Syn-3 KD enhanced Ca2+ currents by 46% attributed mostly to R- and L-type Cavs. Interestingly, while the transmembrane domain of Syn-1A is the putative functional domain modulating Cav activity, it is the cytoplasmic domain of Syn-3 that appears to modulate Cav activity. We conclude that Syn-3 may mimic Syn-1A in the ability to bind and modulate Cavs, but preferring Cav2.3 to perhaps participate in triggering fusion of newcomer insulin SGs during second-phase GSIS
sj-docx-1-taj-10.1177_20406223221083509 – Supplemental material for Effect of sodium-glucose cotransporter-2 (SGLT2) inhibitors on serum urate levels in patients with and without diabetes: a systematic review and meta-regression of 43 randomized controlled trials
No full textSupplemental material, sj-docx-1-taj-10.1177_20406223221083509 for Effect of sodium-glucose cotransporter-2 (SGLT2) inhibitors on serum urate levels in patients with and without diabetes: a systematic review and meta-regression of 43 randomized controlled trials by Alicia Swee Yan Yip, Shariel Leong, Yao Hao Teo, Yao Neng Teo, Nicholas L. X. Syn, Ray Meng See, Caitlin Fern Wee, Elliot Yeung Chong, Chi-Hang Lee, Mark Y. Chan, Tiong-Cheng Yeo, Raymond C. C. Wong, Ping Chai and Ching-Hui Sia in Therapeutic Advances in Chronic Disease</p
Surgical Management of Multiple Myeloma With Symptomatic Involvement of the Spine.
No full textINTRODUCTION
Multiple myeloma (MM) is the most frequent primary malignancy of the spine. We aimed to investigate the clinical presentation, surgical indications and outcomes, complications, survival, and its influencing factors in surgically treated MM patients with symptomatic involvement of the spine (SIS).
METHODS
Retrospective analysis of prospectively collected data. Out of 350 MM patients treated at our institution over a period of 12 years (2006-2018), we identified 24 patients who were surgically treated for SIS. We collected data on demographics, clinical presentation, comorbidities, surgical indications, and outcomes and investigated the factors predisposing to postoperative complications and survival.
RESULTS
The median follow-up duration was 85 months; median overall survival (OS) was 50 months. Clinical presentation at admission included pain (88%), sensory and/or motor deficit (67%), and bowel/bladder dysfunction (25%). Symptomatic pathological fractures were seen in 33%. Predominant surgical indications were rapid neurological deterioration with or without spinal cord compression (SCC), followed by mechanical instability. The majority of our patients benefited from surgery in terms of pain reduction in the short term as well as in the long term. There were 21% patients with surgical-related complications (<3 months). Surgical site infections occurred in 17%, without any obvious factors predisposing to infective complications. Neurological deterioration during hospital stay, especially in the presence of motor deficit and/or bowel/bladder dysfunction, significantly reduced OS.
CONCLUSIONS
Sudden-onset neurological deterioration was the predominant factor leading to surgery. We achieved good short- and long-term pain reduction. Surgery is a valuable option for MM patients with SIS who present with rapid neurological deterioration with or without SCC and/or mechanical instability
Syn-eruptive hydration of volcanic ash records pyroclast-water interaction in explosive eruptions
No full text© The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Hudak, M. R., Bindeman, I. N., Loewen, M. W., & Giachetti, T. Syn-eruptive hydration of volcanic ash records pyroclast-water interaction in explosive eruptions. Geophysical Research Letters, 48(23), (2021): e2021GL094141, https://doi.org/10.1029/2021GL094141.Magma-water interaction can dramatically influence the explosivity of volcanic eruptions. However, syn- and post-eruptive diffusion of external (non-magmatic) water into volcanic glass remains poorly constrained and may bias interpretation of water in juvenile products. Hydrogen isotopes in ash from the 2009 eruption of Redoubt Volcano, Alaska, record syn-eruptive hydration by vaporized glacial meltwater. Both ash aggregation and hydration occurred in the wettest regions of the plume, which resulted in the removal and deposition of the most hydrated ash in proximal areas 400°C) are more important than the cooling rate in facilitating hydration. These observations suggest that syn-eruptive glass hydration occurred where meltwater was entrained at high temperature, in the plume margins near the vent. Ash in the drier plume interior remained insulated from entrained meltwater until it cooled sufficiently to avoid significant hydration.This work was supported by a Geological Society of America Bruce L. "Biff" Reed Scholarship Award and NSF Grant EAR 1822977.2022-05-1
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