670 research outputs found

    Stomach bugs and diabetes: an astounding observation or just confounding?

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    Christopher K. Rayner, Nicholas J. Talley, Michael Horowit

    Hospitals should improve their food culture and lead by example

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    Published: 06 January 2023Brandon Stretton, Joshua G Kovoor, Aashray K Gupta, Nicholas J Talley, Michael Horowit

    Helicobacter pylori infection is not associated with diabetes mellitus, nor with upper gastrointestinal symptoms in diabetes mellitus

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    The definitive version is available at www.blackwell-synergy.comAbstract not availableHarry Hua-Xiang Xia, Nicholas J. Talley, Elisa P. Y. Kam, Lisa J. Young, Johann Hammer, and Michael Horowit

    Gastro-oesophageal reflux disease in adults: Guidelines for clinicians

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    Article first published online: 23 SEP 2008Peter Katelaris, Richard Holloway, Nicholas Talley, David Gotley, Steven Williams and John Den

    Supplemental Material, sj-pdf-1-ojs-10.1177_23259671231181371 - Risk Factors and Outcomes for Preoperative Stiffness Requiring Intervention Before Anterior Cruciate Ligament Reconstruction

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    Supplemental Material, sj-pdf-1-ojs-10.1177_23259671231181371 for Risk Factors and Outcomes for Preoperative Stiffness Requiring Intervention Before Anterior Cruciate Ligament Reconstruction by Nicholas J. Lemme, Daniel S. Yang, Rachel Talley-Bruns, Daniel Alsoof, Alan H. Daniels, Logan Petit and Paul D. Fadale in Orthopaedic Journal of Sports Medicine</p

    Are failproof banking systems feasible? Desirable?

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    In recent years, instability of the banking system has returned as a major problem in many countries, particularly in the developing world. In many cases, this instability has been so threatening to financial intermediation and the functioning of the payments system that governments have felt compelled to intervene and restructure banks, often at considerable cost to the public budget. One response to these problems has been a proposal to create failproof banking systems - to radically transform the structure, priorities, and operation of the banking and financial system. Banks would be limited to issuing deposits, holding essentially riskless portfolios, and operating the payments system. To minimize the resulting disruptions to the financial system, banks would be authorized (and encouraged) to set up holding companies and then transfer to holding company affiliates all the functions - including lending - that banks would no longer be permitted to perform. So while the failproof banking proposal would severely restrict the activity of banks, it would not restrict the activities of banking organizations that convert to a holding company form of organization. This proposal would produce major public benefits. It would assure a nation of a smoothly functioning banking and payments system, would substantially reduce the resources committed to banking supervision, would prevent bank-type regulation from expanding to the rest of the financial system, and would place banking and nonbanking organizations on a level playing field for the financial activities in which they compete. There are two major problems with the proposal. First, it might be difficult to implement because of too few riskless assets in a nation's financial system. (The author suggests several modifications that would alleviate this problem in some countries.) Second, the proposal might hurt the financial market by: (a) increasing interest rates for higher-risk borrowers, forcing them out of the market; and (b) transfering greater risk to the nonbank sector of the financial system, making it more susceptible to crisis. Although the proposal would benefit developing countries (more prone to banking instability) more than industrial countries, it would also be more difficult to implement in developing countries. And the adverse effects of the proposal would be felt more severely in the financial markets of developing countries than in industrial countries, which have deeper, more responsive financial markets.Banks&Banking Reform,Financial Intermediation,Financial Crisis Management&Restructuring,Banking Law,Settlement of Investment Disputes

    Irritable bowel in the community

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    Prof Nicholas J Talley$AUD 57,782.65NHMRC Project GrantsPublic Health Project Gran

    ATG16L1 T300A shows strong associations with disease subgroups in a large Australian IBD population: Further support for significant disease heterogeneity

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    OBJECTIVES: Crohn's disease (CD) and ulcerative colitis (UC) are the two most common forms of inflammatory bowel disease (1131), representing a significant health-care burden. A variant in the autophagy gene ATG16L1 (T300A) has been newly identified as a CD susceptibility locus by genome-wide association. Our aim was to assess the contribution of T300A in determining disease susceptibility and phenotype in two independent Australian IBD cohorts and explore the relationship between T300A and known CD risk factors (NOD2 [nucleotide-binding oligomerization domain containing 2] status and smoking)

    Gastroduodenal disorders

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    Symptoms that can be attributed to the gastroduodenal region represent one of the main subgroups among functional gastrointestinal disorders. A slightly modified classification into the following 4 categories is proposed: (1) functional dyspepsia, characterized by 1 or more of the following: postprandial fullness, early satiation, epigastric pain, and epigastric burning, which are unexplained after a routine clinical evaluation; and includes 2 subcategories: postprandial distress syndrome that is characterized by meal-induced dyspeptic symptoms and epigastric pain syndrome that does not occur exclusively postprandially; the 2 subgroups can overlap; (2) belching disorders, defined as audible escapes of air from the esophagus or the stomach, are classified into 2 subcategories, depending on the origin of the refluxed gas as detected by intraluminal impedance measurement belching: gastric and supragastric belch; (3) nausea and vomiting disorders, which include 3 subcategories: chronic nausea and vomiting syndrome; cyclic vomiting syndrome; and cannabinoid hyperemesis syndrome; and (4) rumination syndrome
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