586 research outputs found
Hippocampal scrapie infection impairs operant DRL performance in mice
No full textIn differential reinforcement of low rates of responding (DRL) tasks, animals are trained to respond for rewards that become available only after some set time has elapsed since the animal's previous response. DRL performance is impaired by hippocampal lesions regardless of their precise location, and can be measured using automated operant equipment, whereas spatial tasks are selectively impaired by dorsal, but not ventral hippocampal lesions, and are typically conducted by hand. Earlier studies of prion infection following dorsal hippocampal microinjections of scrapie have shown clear impairments of spatial alternation, but these occurred significantly later than dysfunction in hippocampus-dependent domestic tasks such as nesting or burrowing. In the present experiment, mice were trained to respond on an automated DRL schedule prior to dorsal hippocampal ME7 scrapie injection. Postoperative DRL performance was monitored, along with performance on domestic and other tests, which provided additional measures of disease progression. Animals with scrapie developed a clear DRL deficit at approximately the same time as their deficits on the other tests became apparent, and long before clinical signs were detectable. DRL deficits thus appeared earlier in the sequence of disease progression than previously reported for spatial alternation, suggesting that early signs of scrapie infection are caused in part by neuronal dysfunction extending beyond the dorsal hippocampal region of initial infection
Derwent Coleridge (1800-83) and the deacon schoolmaster
No full textA persistent oral tradition links Derwent Coleridge, first principal of St Mark's College, Chelsea, to the training of deacon schoolmasters during the period 1841 to 1864. This innovative model of elementary schoolteacher made a distinctive contribution to teacher training in England. Justified theologically rather pedagogically, the deacon schoolmaster model gave the college a unique character in the surge towards a comprehensive system of Church education. This thesis breaks fresh ground by using documentary evidence to test the oral tradition. The introduction of the model and subsequent training of deacon schoolmasters at St Mark's College have been delineated. Alternative models, and their place in Coleridge's experience and thought, are drawn from contemporary sources. The immediate and long-term effects of increasing control over teacher training by central government, and the impact of opinions within the Church, are assessed in relation to Derwent Coleridge's aims for the College. These influences are described in the context of public debate on deacon schoolmasters in three mid-nineteenth century settings: the Church, Parliament, and the British colonies. The international dimension to the deacon-schoolmaster model is one that previously has not been researched. Hitherto unused documentary sources have added important detail to imprecise elements in the oral tradition of St Mark's College, and re-examination of little-known material has refreshed and broadened the conventional interpretation and estimate of significance of deacon schoolmasters. Finally, by tracing historical continuities, the main focus on a particular episode in nineteenth-century education has cast light upon new opportunities for deacon schoolmasters (and -mistresses) in the earty twenty-first century.EThOS - Electronic Theses Online ServiceGBUnited Kingdo
A compleat collection of devotions : both publick and private : taken from the apostolical constitutions, the ancient liturgies, and the Common prayer book of the Church of England ... [etc.].
No full textSignatures: [pi]¹, A?, A-Y?, Z?, a-h?, i? (final verso blank).; Attributed to Thomas Deacon.; Label: Library of the Congregation of U.B. of the Borough of Bethlehem and its vicinity, no. 877.; Signature; B. Ingham.; An appendix in justification of the foregoing undertaking ... has separate title and pagings.; BM,; ESTC
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Deacon King Kong /
No full text"From James McBride, author of the National Book Award-winning The Good Lord Bird, comes a wise and witty novel about what happens to the witnesses of a shooting. In September 1969, a fumbling, cranky old church deacon known as Sportcoat shuffles into the courtyard of the Cause Houses housing project in south Brooklyn, pulls a .45 from his pocket, and in front of everybody shoots the project's drug dealer at point-blank range. The reasons for this desperate burst of violence and the consequences that spring from it lie at the heart of Deacon King Kong, James McBride's funny, moving novel and his first since his National Book Award-winning The Good Lord Bird. In Deacon King Kong, McBride brings to vivid life the people affected by the shooting: the victim, the African-American and Latinx residents who witnessed it, the white neighbors, the local cops assigned to investigate, the members of the Five Ends Baptist Church where Sportcoat was deacon, the neighborhood's Italian mobsters, and Sportcoat himself. As the story deepens, it becomes clear that the lives of the characters--caught in the tumultuous swirl of 1960s New York--overlap in unexpected ways. When the truth does emerge, McBride shows us that not all secrets are meant to be hidden, that the best way to grow is to face change without fear, and that the seeds of love lie in hope and compassion. Bringing to these pages both his masterly storytelling skills and his abiding faith in humanity, James McBride has written a novel every bit as involving as The Good Lord Bird and as emotionally honest as The Color of Water. Told with insight and wit, Deacon King Kong demonstrates that love and faith live in all of us"-
Students of St. Nicholas sunday school on steps of church
No full textStudents of St. Nicholas Sunday School on steps of church, c. 1940 (Row 1) Steve Diamandas, Peter Petropoulos, Bill Mavrode, Arthur Anest, Gus Diamandas, Leo Sirakedis, Nick Juvelis, Anthony Vlastaras, Antonias, Marigo Pappas, Corinne Pappas, Anna Katsoris, Mary Demos, Esther Argyris, Ann Nikitakis, Bertha Panagakos, Mary Thomas, Helen Argyris, Esther Dokas, (Row 2) T. Papastavros, John Bravakis, John Antonacos, Spero Gevas, Gus Karampulos, Tom Gevas, George Panagakos, Gus Karanicholas, John Shenis, Mary Karanasos, Fifi Prassas, Cathy Karampulos, Sophie Micheludis, Aphrodite Kasmias, Angie Halamandaris, Jean Pontiakos, Doris Churus, Beatice Gevas, Cordelia Gevas, (Row 3) Billy Theofilos, Jim Policantriotis, Jim Gevas, Arthur Carpousis, Stragalas, Dino Bliablias, George Zografos, Anna Stragalas, Fotini, Percy Peters, Elaine Sideris, Pauline Stefanos, Penelope Pappas, Helen Sideris, Estelle Bravakis, (Row 4) Father G. Spyridakis, Ted Halamandaris, Jim Maroulakos, Chris Sirakedis, Steve Karas, Jim Pallantios, Peter Kapsimalis, Catherine Mandos, Mary Tomasco, Helen G., Eugenia Gevas, Betty Kafalas, Zoe Javas, Emorfia Gevas, Bertha Javas, Deacon Kokkinakis, (Row 5) Pete Thomas, Karanasos, Steve Sgourakis, Steve Tsavlis, teacher Athena Sarantos, Georgia Pagonis, Angie Juvelis, Olympia Zografos, Mrs. Spyridakis.Courtesy of John Sheni
Holy Communion at St. Nicholas Greek Orthodox Church
No full textReverend Peter Kostakos giving Holy Communion to a parishioner during the Divine Liturgy in church. He was born and raised in Newark, ordained a Deacon by Reverend George Spyridakis at St. Nicholas Greek Orthodox Church, became a priest and after his retirement assisted Reverend J.A. Aloupis during the Divine Liturgy in the church, c. 1990's
Can gold be an effective catalyst for the Deacon reaction?
No full textThe Deacon reaction is an important industrial process for the oxidation of hydrogen chloride, thereby enabling chlorine to be recycled. As gold is an efficient catalyst for reactions involving hydrogen chloride and oxygen, we have studied the use of gold as a potential catalyst for the Deacon reaction. Unfortunately, gold displays only limited activity; however, this is markedly increased if hydrogen is cofed as a reactant
Behavioral consequences of prion disease targeted to the hippocampus in a mouse model of scrapie
No full textSheep scrapie is an archetypal member of a group of chronic neurodegenerative diseases that can afflict both humans and animals and that are known collectively as the transmissible spongiform encephalopathies or prion diseases. The study of these diseases has been facilitated by the experimental transmission of sheep scrapie to laboratory rodents, and this has led to an ever-increasing literature on the pathogenesis and molecular biology of this unusual group of diseases. There is relatively little known about the relationship between the chronic neurodegenerative process and the development of clinical signs, the latter occurring very late in the course of the disease after a prolonged incubation period. We have previously shown that following intrahippocampal injection of scrapie brain homogenate, there is an early inflammatory response in the brains of affected mice. This develops long before there is neuronal loss and also before the mice develop any overt clinical signs of disease. It was surprising that despite the marked and evolving inflammatory response in the brains of scrapie-affected mice, indicative of underlying pathology, there were no outward signs that the mice had any form of central nervous system pathology. The present study shows that by using a number of behavioral tasks, including multitrial passive avoidance, open-field motor activity, and tests of muscle strength, it is possible to detect more subtle clinical signs much earlier during the course of disease in scrapie-affected mice. The relevance of this finding to the investigation of mouse scrapie is discussed.</p
Burrowing into prion disease
No full textMice received intra-hippocampal injections of scrapie-infected brain homogenate. Open field activity increased from around week 12 post-injection. Concomitantly the tendency to displace food from a tube inside the home cage decreased. The food was generally dug out with the feet, rather than carried by mouth, so its displacement was called burrowing. Food restriction was unnecessary for this burrowing to occur. Only later, around 18 weeks, did more general motor impairments develop. As burrowing in scrapie-infected mice decreased when open field activity increased, and preceded later motor impairments, it was not due to motor dysfunction. Burrowing is a simple, sensitive, objective, ethological measure, sensitive to preclinical prion disease. Other potential applications are in transgenic and knockout mice, models of ageing and Alzheimer's disease, and pharmacology, particularly neuroleptics
Actualisation of classic vs. academic history of philosophy (with reference to the article of deacon M. Bulanenko)
No full textIn this paper the author gives the answer to the position of deacon M. Bulanenko, published in tis volume
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