7,028 research outputs found

    From proteomics to prescription - the search for COPD biomarkers

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    Biomarkers that describe the severity and progression of COPD and the responses of patients to treatment are a desirable addition to clinical measures of disease. In this review, we describe the current state of knowledge of biomarkers used for the diagnosis, staging and therapeutic response of COPD patients. The nature of these biomarkers is considered in relation to their intended use, and the desirable qualities of such entities are examined. Examples of biased and unbiased discovery platforms for COPD biomarker discovery are given, and the major findings of these studies are discussed. Cutting edge technology used for biomarker discovery, quantitation in biofluids and imaging biomarkers in whole body systems is reviewed

    The cult of St Nicholas in medieval Italy

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    St Nicholas was one of the most popular saints in medieval Italy. His cult attracted the attention of popes, kings and emperors, and his shrine at Bari became an important international pilgrimage destination. This thesis asks how the cult of St Nicholas came to be so widespread and popular in Italy, and why the saint attracted the attention of diverse groups and individuals. This thesis is structured around four chapters. The first demonstrates that through a process of Latinisation the cult of St Nicholas became integrated within Italian literary traditions and within a new spiritual era. Chapter Two reveals that this Latinisation also occurred within the saint’s iconography. Chapters Three and Four are case studies of the cult in Puglia and Venice, locations which claimed possession of the saint’s relics. These case studies show that the general developments that the cult of St Nicholas underwent in Italy, identified in Chapters One and Two, did not apply universally. Instead, the presence of the saint’s relics resulted in a different profile of the saint in Bari and Venice. Through the process of Latinisation, the cult of St Nicholas became updated and remained relevant for its new Italian audience; Chapters Three and Four show alternative ways that the cult of St Nicholas gained widespread popularity. This thesis presents for the first time an iconographical study of St Nicholas in Italian art, which develops existing research of the saint’s Byzantine iconography. Chapter Four presents a profile of the cult of St Nicholas in Venice in the Middle Ages, which is a significant oversight in the literature. The thesis uses a variety of visual and textual sources, in particular fresco and altarpiece representations, archival documents from Venice and Rome (including the Apostolic Visitations), and under-exploited contemporary and antiquarian Venetian sources

    Public worship and practical theology in the work of Benjamin Keach (1640-1704)

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    The late seventeenth century was a critical and fruitful period for the Particular Baptists of England. Severely persecuted following the Restoration, toleration in 1689 brought its own perils. Particular Baptists were fortunate in having several strong leaders, especially the London trio of Hanserd Knollys, William Kiffin, and Benjamin Keach. Such a small and severely persecuted group as the Baptists could afford little time for academic pursuits, thus of necessity most of their theology was practical in nature. Benjamin Keach (1640-1704) was the most outstanding practical theologian among the English Particular Baptists of the late seventeenth century. This dissertation is a study of Keach, in particular his writings on public worship and practical theology. Although Keach was a prolific author, he has been almost completely neglected by scholars. After a biographical sketch of Keach, this study considers his writings on public worship and practical theology. In the area of worship, Keach made two outstanding contributions: First, he was the most vocal apologist for Baptist views on Baptism of his period. Secondly, and more importantly, his hymn writing and defense of hymn singing broke new ground, not just for Baptists, but for English Protestantism, in general. In addition to his contributions in these areas, he also dealt with the laying on of hands and the sabbath day worship controversy. Keach's contributions to practical theology fall into two main groups: his writings that concern religious education and those that deal with polity. In addition to these, Keach's vigorous advocacy of a high Calvinist soteriology are also considered under the rubric of practical theology. Keach's most important (although not his most positive) contribution in this area were his soteriological writings. Although well within the bounds of orthodoxy, some of the tendencies in Keach's soteriology were taken up by the following generation of Baptist leaders and developed into a stultifying hyper-Calvinism that handicapped Baptist evangelism and missions. In the conclusion, Keach's contributions to a theory of practical theology are considered

    The concept of remembrance in Walter Benjamin

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    This thesis argues that the role played by the concept of remembrance (Eingedenken) in Walter Benjamin's 'theory of the knowledge of history' and in his engagement with Enlightenment universal history, is a crucial one. The implications of Benjamin's contention that history's 'original vocation' is 'remembrance' have hitherto gone largely unnoticed. The following thesis explores the meaning of the concept of remembrance and assesses the significance of this proposed link between history and memory, looking at both the mnemonic aspect of history and the historical facets of memory. It argues that by mobilising the simultaneously destructive and constructive capacities of remembrance, Benjamin sought to develop a critical historiography which would enable a radical encounter with a previously suppressed past. In so doing he takes up a stance (explicit and implicit) towards existing philosophical conceptions of history, in particular the idea of universal history found in German Idealism. Benjamin reveals an intention to retain the epistemological aspirations of universal history whilst ridding that approach of its apologetic moment. He criticises existing conceptions of history on the basis that each assumes homogeneous time to be the framework in which historical events occur. Insight into the distinctive temporality of remembrance proves to be the touchstone for this critique, and provides a paradigm for a very different conception of time. The thesis goes on to determine what is valid and what is problematic both in this concept of remembrance and in the theory of historical knowledge which it informs, by subjecting both to the most cogent criticisms which can be levelled at them. What emerges is not only the importance of this concept for an understanding of Benjamin's philosophy but the pertinence of this concept for any philosophical account of memory

    Biomarker Magazine Winter 2015, vol. 9

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    Made available in DSpace on 2021-11-04T17:11:53Z (GMT). No. of bitstreams: 2 2015v9.Biomarker.pdf: 43677805 bytes, checksum: 74a6343c2902755f5f281a910f9d55b7 (MD5) license.txt: 4802 bytes, checksum: 58353f9dd6876860dd5221f3d7872a95 (MD5) Previous issue date: 2015-01Vasi, Nicholas (Managing Editor); Faith, Kathryn (Design); Ahlberg, Liz (Writer); Benjamin, Claire (Writing); Chakalian, Paul (Writing); Kreig, Alex (Writing); Jongeneel, Susan (Writing); Lutz, Claudia (Writing); McKenna, Susan (Writing); O’Neil, Kathleen (Writing); Schwink, Siv (Writing); Vasi, Nicholas (Writing); Yates, Diana (Writing); Ahlers, Haley (Imagery); Bouwmeester, Jessica (Imagery); Faith, Kathryn (Imagery); Fouke, Bruce (Imagery); Gabriel, Horton (Imagery); Lee, Mirhee (Imagery); Lindsay, Jason (Imagery); Metcalf, Kathryne (Imagery); O’Neil, Kathleen (Imagery); Petzelt, Barbara (Imagery); Stauffer, L. Brian (Imagery

    Biomarker Magazine Winter 2016, vol. 10

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    Made available in DSpace on 2021-11-04T17:11:52Z (GMT). No. of bitstreams: 2 2016v10.Biomarker.pdf: 6061111 bytes, checksum: 851def3ea4fcddd2ce1d6732ce5d92e1 (MD5) license.txt: 4802 bytes, checksum: 58353f9dd6876860dd5221f3d7872a95 (MD5) Previous issue date: 2016-01Vasi, Nicholas (Managing Editor); Faith, Kathryn (Design); Lutz, Claudia (Writing); Metcalf, Kathryne (Writing); Barnes, Anna (Writing); Benjamin, Claire (Writing); Buller, Rachel (Writing); Harris, Olivia (Writing); Kalsotra, Auinash (Writing); Keating, Austin (Writing); Quinn, Lauren (Writing); Schiess, August (Writing); Schwink, Siv (Writing); Touchstone, Liz Ahlberg (Writing); Yates, Diana (Writing); Faith, Kathryn (Imagery); Afanador, Yashira (Imagery); Ahlers, Haley (Imagery); Benjamin, Claire (Imagery); Jost, John (Imagery); McMahon, Julie (Imagery); Nasir, Arshan (Imagery); Oleksyk, Taras (Imagery); Sears, Karen (Imagery); Stauffer, L. Brian (Imagery); Tiwari, Saumya (Imagery

    Letter to Benjamin Clark Cutler from Benjamin Stevens

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    Letter dated April 14, 1863 to Assistant Adjutant General, Captain Benjamin Clark Cutler, Santa Fe, from First Lieutenant Benjamin Stevens, Fort Wingate, New Mexico, recommending John Murphy and Martin Quintana, in the First New Mexico Volunteers, for military promotion to Second Lieutenant. Letter also signed by First Lieutenant J. L. Barbey, joint author. Civil War. HL introduction page overlaid by document. Letter in English, handwritten, 1pp/fr

    sj-docx-1-aop-10.1177_10600280211073370 – Supplemental material for Determinants of Vancomycin Trough Concentration in Patients Receiving Continuous Veno-Venous Hemodialysis

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    Supplemental material, sj-docx-1-aop-10.1177_10600280211073370 for Determinants of Vancomycin Trough Concentration in Patients Receiving Continuous Veno-Venous Hemodialysis by Nicholas J. Quinn, Gretchen L. Sacha, Matthew R. Wanek, Jason Yerke, Pavithra Srinivas and Benjamin Hohlfelder in Annals of Pharmacotherapy</p

    The Democratic State

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    Roger Benjamin was president of the Council for Aid to Education (CAE) from 2005 to 2019 and was formerly provost of the University of Minnesota and the University of Pittsburgh. He has authored, coauthored, or co-edited nine books, including The Democratic Purposes of Education and The New Limits of Education Policy: Avoiding a Tragedy of the Commons. Stephen L. Elkin is professor emeritus of government and politics at the University of Maryland and founding editor of the journal The Good Society. He is the author or editor of seven books, including Reconstructing the Commercial Republic: Constitutional Design after Madison.This Kansas Open Books title is funded by a grant from the National Endowment for the Humanities and the Andrew W. Mellon Foundation Humanities Open Book Program.Edited by Roger Benjamin and Stephen L. Elkin. Contributors include Peter H. Aranson, Roger Benjamin, David Braybrooke, Stephen L. Elkin, Norman Furniss, and Peter C. Ordeshook.One outcome of the declining economic growth and rising political conflict of the 1980s has been a renewed interest in political theory and increased questioning about the durability of the capitalist state. More and more political scientists are critically assessing the prevailing pluralist vision of the relationships between the state and the economy. Is the capitalist state able to adjust to crises and contradictions? What is the role of the state in changing—deteriorating—economic circumstances? How should we understand competing interpretations on the relative autonomy of the state, the nature of property rights, the legitimation crisis? This collection of five original essays by seven of the best-known political-economy theorists addresses the interconnections between the economy and the polity and embodies the leading theoretical approaches to the political economy of the state
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