4,043 research outputs found
A field study of team working in a new human supervisory control system
No full textThis paper presents a case study of an investigation into team behaviour in an energy distribution company. The main aim was to investigate the impact of major changes in the company on system performance, comprising human and technical elements. A socio-technical systems approach was adopted. There were main differences between the teams investigated in the study: the time of year each control room was studied (i.e. summer or winter),the stage of development each team was in (i.e. 10 months), and the team structure (i.e. hierarchical or heterarchical). In all other respects the control rooms were the same: employing the same technology and within the same organization. The main findings were: the teams studied in the winter months were engaged in more `planning’ and `awareness’ type of activities than those studies in the summer months. Newer teams seem to be engaged in more sharing of information than older teams, which maybe indicative of the development process. One of the hierarchical teams was engaged in more `system-driven’ activities than the heterarchical team studied at the same time of year. Finally, in general, the heterarchical team perceived a greater degree of team working culture than its hierarchical counterparts. This applied research project confirms findings from laboratory research and emphasizes the importance of involving ergonomics in the design of team working in human supervisory control
Self-compression of 4.9 µm pulses to sub-40 fs with 2 mJ energy in Zinc Sulfide
No full textNonlinear self-compression of few-cycle multi-mJ pulses at 4.9 µm in ZnS is presented. 80 fs input pulses are compressed to 37 fs with 2.1 mJ energy at a 1 kHz repetition rate. © 2024 The Author(s
Prevalence, incidence and risk factors of epilepsy in older children in rural Kenya.
No full textBACKGROUND: There is little data on the burden or causes of epilepsy in developing countries, particularly in children living in sub-Saharan Africa. METHODS: We conducted two surveys to estimate the prevalence, incidence and risk factors of epilepsy in children in a rural district of Kenya. All children born between 1991 and 1995 were screened with a questionnaire in 2001 and 2003, and those with a positive response were then assessed for epilepsy by a clinician. Active epilepsy was defined as two or more unprovoked seizures with one in the last year. RESULTS: In the first survey 10,218 children were identified from a census, of whom 110 had epilepsy. The adjusted prevalence estimates of lifetime and active epilepsy were 41/1000 (95% CI: 31-51) and 11/1000 (95% CI: 5-15), respectively. Overall two-thirds of children had either generalized tonic-clonic and/or secondary generalized seizures. A positive history of febrile seizures (OR=3.01; 95% CI: 1.50-6.01) and family history of epilepsy (OR=2.55; 95% CI: 1.19-5.46) were important risk factors for active epilepsy. After the second survey, 39 children from the same birth cohort with previously undiagnosed epilepsy were identified, thus the incidence rate of active epilepsy is 187 per 100,000 per year (95% CI: 133-256) in children aged 6-12 years. CONCLUSIONS: There is a considerable burden of epilepsy in older children living in this area of rural Kenya, with a family history of seizures and a history of febrile seizures identified as risk factors for developing epilepsy
Identification of differentially expressed sense and antisense transcript pairs in breast epithelial tissues
No full textBackground: More than 20% of human transcripts have naturally occurring antisense products (or natural antisense transcripts – NATs), some of which may play a key role in a range of human diseases. To date, several databases of in silico defined human sense-antisense (SAS) pairs have appeared, however no study has focused on differential expression of SAS pairs in breast tissue. We therefore investigated the expression levels of sense and antisense transcripts in normal and malignant human breast epithelia using the Affymetrix HG-U133 Plus 2.0 and Almac Diagnostics Breast Cancer DSA microarray technologies as well as massively parallel signature sequencing (MPSS) data.
Results: The expression of more than 2500 antisense transcripts were detected in normal breast duct luminal cells and in primary breast tumors substantially enriched for their epithelial cell content by DSA microarray. Expression of 431 NATs were confirmed by either of the other two technologies. A corresponding sense transcript could be identified on DSA for 257 antisense transcripts. Of these SAS pairs, 163 have not been previously reported. A positive correlation of differential expression between normal and malignant breast samples was observed for most SAS pairs. Orientation specific RT-QPCR of selected SAS pairs validated their expression in several breast cancer cell lines and solid breast tumours.
Conclusion: Disease-focused and antisense enriched microarray platforms (such as Breast Cancer DSA) confirm the assumption that antisense transcription in the human breast is more prevalent than previously anticipated. Expression of a proportion of these NATs has already been confirmed by other technologies while the true existence of the remaining ones has to be validated. Nevertheless, future studies will reveal whether the relative abundances of antisense and sense transcripts have regulatory influences on the translation of these mRNAs
Correction to: Chamoun et al., Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection
No full textChamoun MN, Blumenthal A, Sullivan MJ, Schembri MA, Ulett GC. 2018. Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection. Critical Reviews in Microbiology. https://doi.org/10.1080/1040841X.2018.1426556.
When the above article was first published online, the below three corrections were missed.
The author ‘Antje Blumenthal’ was wrongly affiliated to the affiliation “cSchool of Chemistry and Molecular Biosciences, and Australian Infectious Disease Research Centre, The University of Queensland, Brisbane, Australia”. Now this affiliation has been removed for this author.
The affiliation ‘bTranslational Research Institute, The University of Queensland Diamantina Institute, Woolloongabba, Australia’ of the author ‘Antje Blumenthal’ should read ‘bThe University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia’.
In Table 3, the sentence ‘Benefit of manipulating IL-17 levels to improve immunization strategies M. tuberculosis’ should read “Benefit of manipulating IL-17 levels to improve immunization strategies against M. tuberculosis”.No Full Tex
Generation of 22-mJ, 2.0-ps Pulses from a 1-kHz Ho:YLF Regenerative Chirped Pulse Amplifier
No full textWe report a CW-pumped Ho:YLF regenerative amplifier (RA) delivering pulses with 22.5-mJ energy and 2.0-ps duration at 1 kHz. The RA emitting at 2051 nm is broadband-seeded and implemented in a chirped pulse amplification system. © 2024 The Author(s
Pure-rotational 1D-CARS spatiotemporal thermometry with a single regenerative amplifier system
No full textWe report spatiotemporal pure-rotational coherent anti-Stokes Raman spectroscopy (CARS) in a one-dimensional imaging arrangement obtained with a single ultrafast regenerative amplifier system. The femtosecond pump/Stokes photon pairs, used for impulsive excitation, are delivered by an external compressor operating on a ∼35% beam split of the uncompressed amplifier output (2.5 mJ/pulse). The picosecond 1.2 mJ probe pulse is produced via the second-harmonic bandwidth compression (SHBC) of the ∼65% remainder of the amplifier output (4.5 mJ/pulse), which originates from the internal compressor. The two pump/Stokes and probe pulses are spatially, temporally, and repetition-wise correlated at the measurement, and the signal generation plane is relayed by a wide-field coherent imaging spectrometer onto the detector plane, which is refreshed at the same repetition rate as the ultrafast regenerative amplifier system. We demonstrate 1 kHz cinematographic 1D-CARS gas-phase thermometry across an unstable premixed methane/air flame-front, achieved with a single-shot precision <1% and accuracy <3%, 1.4 mm field of view, and an excellent <20 µm line-spread function.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Flight Performance and Propulsio
Project: Establishing an accounting outsourcing company "MJ Grāmatvedība" Ltd
No full textProjekta ideja ir izveidot grāmatvedības ārpakalpojumu uzņēmumu SIA „MJ Grāmatvedība”, kurš sniegtu pilna vai daļēja cikla grāmatvedības pakalpojumus, sākot ar pirmreizējo dokumentu apstrādi un beidzot ar visu nepieciešamo atskaišu sagatavošanu, kā arī konsultāciju sniegšanu. Projekta mērķis ir ne tikai sniegt grāmatvedības pakalpojumus, bet arī analizēt uzņēmumu darbību un izstrādāt ieteikumus darbības uzlabošanai. Darba autore uzskata, ka nozares pārstāvjiem ir būtiski jāpierāda sava nozīme un to kādam jābūt mūsdienu grāmatvedim. Grāmatvedis nav tikai persona, kura izdara konkrētus darbus, nodos atskaites, tas ir cilvēks, kuram labi jāpārzina nodokļu sistēma, finanšu vadīšana, jāspēj sniegt padomus uzņēmuma finanšu vadības uzlabošanai, kā arī jāspēj pielāgoties tehnoloģiju radītajām izmaiņām. Maģistra darbs apjoms ir uz 105 lappusēm, kas sastāv no 7 nodaļām, 17 pielikumiem, 22 tabulām un 7 attēliem. Darba izstrādē izmantoti 70 informācijas avoti.The general project idea is to establish the accountancy firm MJ Accountancy Ltd., which would provide full or half-cycle accountancy services including the processing of primary documentation, reports’ preparation, and providing of the accountancy consultations. The aim of the project is not only to provide accountancy consultations but also to deal with firms activity analysis and developing suggestions on their activity improvement. The author of the project supports the idea that the field representatives must constantly sustain the status of the accountant’s profession in current times. The accountant is not only the person who executes one’s regular duties and submits reports, but also the person who is competent in the field of taxes, financial management, able to advise on improvements in financial management, and above all able to adapt to the technological changes. The volume of the project is 105 pages, which includes 7 chapters, 17 appendices, 22 tables, 7 figures. 70 sources of information were used in master’s thesis
Initial state and transition-state solvation effects in the cobaltotungstate oxidation of iodide in binary aqueous solvent mixtures
No full textPT: J; CR: AMJAD Z, 1977, CAN J CHEM, V55, P3581 BAKER LCW, 1956, J AM CHEM SOC, V78, P4503 BECK MT, 1968, COORDIN CHEM REV, V3, P91 BLANDAMER MJ, UNPUB CAN J CHEM BLANDAMER MJ, 1978, J CHEM SOC CHEM COMM, P963 BLANDAMER MJ, 1979, PURE APPL CHEM, V51, P2087 BLANDAMER MJ, 1980, COORDIN CHEM REV, V31, P93 BLANDAMER MJ, 1980, J CHEM SOC DA, P1 BLANDAMER MJ, 1980, J CHEM SOC DA, P2442 BRODOVITCH JC, UNPUB BURGESS J, 1968, J CHEM SOC A, P2571 BURGESS J, 1970, J CHEM SOC A, P2111 BURGESS J, 1970, J CHEM SOC A, P2351 BURGESS J, 1972, INORGANIC REACTION M, V2, P127 BURGESS J, 1973, J CHEM SOC A, P825 BURGESS J, 1974, INORGANIC REACTION M, V3, P142 BURGESS J, 1977, INORGANIC REACTION M, V5, P158 BURGESS J, 1979, INORGANIC REACTION M, V6, P168 COX BG, 1974, ANN REP CHEM SOC A, V71, P249 COX BG, 1979, J CHEM SOC F1, V75, P1780 COX BG, 1979, J CHEM SOC FARAD T 1, V75, P86 DELIGNY CL, 1965, RECL TRAV CHIM PAY B, V84, P81 ELLIS KJ, 1973, J CHEM SOC DA, P1533 GRUNWALD E, 1948, J AM CHEM SOC, V70, P846 KANEMAQUIRE LAP, 1975, J CHEM SOC DA, P1890 KEPERT DL, 1978, J CHEM SOC DA, P137 MARCUS RA, 1968, J PHYS CHEM-US, V72, P891 PELIZZETTI E, 1976, INORG CHEM, V15, P2898 SUBHANI MS, 1978, REV ROUMAINE CHIM, V23, P719 UDOVENKO VV, 1977, RUSS J INORG CHEM, V22, P168 WELLS CF, 1973, J CHEM SOC FARAD T 1, V69, P984 WELLS PR, 1968, LINEAR FREE ENERGY R, CH4; NR: 32; TC: 14; J9: TRANSIT METAL CHEM; PG: 4; GA: NG073Source type: Electronic(1
An extension of the weighted sum of gray gases non-gray gas radiation model to a two phase mixture of non-gray gas with particles
No full textA great deal of efforts has been exercised to date to accurately model the non-gray behavior of the gases. Among others, the weighted sum of gray gases model (WSGGM), which replaces the non-gray gas behavior by an equivalent finite number of gray gases, is a simplified model yielding reasonable results. However, a discussion on the weighting factors required for an estimation of radiation in a mixture of non-gray gas/gray particulate is not yet established for WSGGM, since they are dependent on the particle number density, particle size distribution: local temperature and partial pressure. Consequently, the relation between the weighting factors used in the WSGGM for a mixture of non-gray gas and gray particles with scattering in the thermal non-equilibrium has been discussed here, which has not been done before to the author's best knowledge. Weighting factors for the particles, of which temperature is different from that of the gas, were evaluated analytically for the WSGGM. The results were, then, validated for the problem of isothermal gas containing soot particulates between two parallel slab walls. For further application, the approach derived here was implemented to examine the non-gray radiative effects of the two phase mixture in an axisymmetric cylinder by changing such various parameters as the particle temperature, non-gray gas composition and particle concentration. The effects of thermal non-equilibrium in a mixture of gas and particles were also discussed in parallel with scattering effects by particles. Parametric study showed that a variation in the gas concentration yielded a noticeable change in the radiative heat transfer when the suspended particle temperature was different from the gas temperature. New contribution of this study consisted in an extension of applicability of the WSGGM non-gray model to two phase radiation. (C) 2000 Elsevier Science Ltd. All rights reserved.The authors wish to acknowledge the financial support of the Korea Research Foundation made in the program year of 1998 under the contract 1998-018-E00016
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