1,721,751 research outputs found
Influence of hepatopathies on platelet count in dogs.
No full textChanges of the platelet count in liver diseases are described in humans. Thrombocytopenia was observed more frequently than thrombocytosis. There are only a few investigations on platelet counts in liver diseases in dogs. The goal of the present study was to investigate the influence of different liver diseases including degeneration, hepatitis and liver tumours, on the platelet count. Platelet counts of 52 dogs with different liver diseases were measured and compared with 52 healthy dogs. The results showed, that dogs with liver degeneration have thrombocytosis in 41% of the cases and a group of dogs with liver tumours (malignant histiocytosis, hepatoma, malignant lymphoma anaplastic sarcoma, cholangiocarcinoma, hepatocellular carcinoma) had thrombocytopenia in 50% of the cases. The dogs with hepatitis showed no specific changes in the platelet count. The statistical comparison of our patients with liver disease and a control group of healthy dogs showed significantly higher platelet counts in cases of liver degeneration (p < 0.0001) and significantly lower platelet counts in cases of liver tumour (p < 0.001). The comparison between the dogs with different liver diseases showed significantly lower platelet counts in dogs with liver tumours when compared to dogs with liver degeneration (p < 0.0001). There was no significant difference between dogs with liver tumours and dogs with hepatitis and between dogs with liver degeneration and dogs with hepatitis. Based on the results of this study the author recommends to assess platelet counts in all dogs with liver disease, especially if liver biopsy is planed
Epidemiologic, clinical and laboratory diagnostic findings in dogs with hepatopathies
No full textThe knowledge about the epidemiology of an illness is important for the diagnostic procedure, the course and the prognosis of the disease. Studies about the epidemiology of liver diseases in dogs are rare in the veterinary literature. Goal of our investigation was collection of epidemiological items and comparison with veterinary and human literature. Altogether 100 dogs with hepatopathy were investigated in this study. The hepatopathies were diagnosed histologically. In our study liver degeneration appeared most frequently, followed by liver tumours and hepatitis. A vascular liver disease was found only in one case. We could not find any race disposition. The patients with degenerative liver disease, neoplasia and hepatitis were older than 9-10 years. Only the patient with the vascular liver disease, a portosystemic shunt, was clear younger (3 years). We could not find any sex disposition. Predominant symptoms of our patients were disturbed general state of health and inappetence, diarrhoea, vomiting and polyuria/polyclipsia. Abdominal distension and pain we observed more in cases of neoplasia and hepatitis. Icterus, pruritus and hemorrhage were rare symptoms of hepatopathy in our study. The statistical analysis of our laboratory parameters showed significant increase of ALT activity in dogs with hepatitis. Dogs with liver degeneration have significant increased AST activities. GLDH was tendentious higher in dogs with hepatitis. Bile acids were significant increased at dogs with liver tumours. Albumin was significant decreased in dogs with neoplasia. Most of our cases have moderate until poor prognosis. Dogs with liver degeneration died frequently based on the primary disease. The patient with a portosystemic shunt was healed after operation. Our data and those of the veterinary literature showed agreement predominantly
Blood parameters for liver function in dogs
No full textBlood parameters are an integral part of liver diagnostics. Their value for etiopathogenesis is however limited. For assessment of liver function blood parameters are non the less essential. In addition to routine parameters like albumin, prothrombin time, urea and bile acids, the two new parameters IGF I and phenylalanine, an amino acid, are discussed
Epidemiologic, clinical and laboratory diagnostic findings in dogs with hepatopathies
No full textThe knowledge about the epidemiology of an illness is important for the diagnostic procedure, the course and the prognosis of the disease. Studies about the epidemiology of liver diseases in dogs are rare in the veterinary literature. Goal of our investigation was collection of epidemiological items and comparison with veterinary and human literature. Altogether 100 dogs with hepatopathy were investigated in this study. The hepatopathies were diagnosed histologically. In our study liver degeneration appeared most frequently, followed by liver tumours and hepatitis. A vascular liver disease was found only in one case. We could not find any race disposition. The patients with degenerative liver disease, neoplasia and hepatitis were older than 9-10 years. Only the patient with the vascular liver disease, a portosystemic shunt, was clear younger (3 years). We could not find any sex disposition. Predominant symptoms of our patients were disturbed general state of health and inappetence, diarrhoea, vomiting and polyuria/polyclipsia. Abdominal distension and pain we observed more in cases of neoplasia and hepatitis. Icterus, pruritus and hemorrhage were rare symptoms of hepatopathy in our study. The statistical analysis of our laboratory parameters showed significant increase of ALT activity in dogs with hepatitis. Dogs with liver degeneration have significant increased AST activities. GLDH was tendentious higher in dogs with hepatitis. Bile acids were significant increased at dogs with liver tumours. Albumin was significant decreased in dogs with neoplasia. Most of our cases have moderate until poor prognosis. Dogs with liver degeneration died frequently based on the primary disease. The patient with a portosystemic shunt was healed after operation. Our data and those of the veterinary literature showed agreement predominantly
Blood parameters for liver function in dogs
No full textBlood parameters are an integral part of liver diagnostics. Their value for etiopathogenesis is however limited. For assessment of liver function blood parameters are non the less essential. In addition to routine parameters like albumin, prothrombin time, urea and bile acids, the two new parameters IGF I and phenylalanine, an amino acid, are discussed
Creatine kinase-activity in dogs and cats with metabolic diseases
No full textElevated Creatine kinase-activitiy (CK) indicates disturbances of the muscle cell integrity. In addition to primary muscle disease, like trauma, inflammation or dystrophy, diseases of other organs can lead to secondary muscle involvement, which will be indicated by increased serum activities of the CK. The mechanisms of muscle cell disturbance are still unknown. An elevated protein catabolism in the muscle cell is suspected. In the present study we investigated, if dogs and cats with metabolic diseases have increased CK-activity in the serum. From 34 dogs and cats in a group with different metabolic diseases without metabolic acidosis 19 % of the dogs and 50 % of the cats had increased CK-activity in the serum. From 33 dogs and cats with different metabolic diseases connected with metabolic acidosis 86 % of the dogs and 95 % of the cats had simultaneously increased CK-activity in the serum. In comparison to healthy dogs and cats animals with metabolic diseases have significant and in cases of metabolic di-seases with metabolic acidosis cats have high significant elevation (dogs Significant) of CK-activity in the serum. There was no significant correlation between the groups of patients. In conclusion we think that our results show that metabolic diseases often induce secondary myopathy, measured by CK-activity in the serum, but metabolic acidosis has no direct influence on elevated CK activity in dogs and cats
Rare cases of lameness in dogs
No full textWe describe four seldom aetiologies for lameness in dogs: idiopathic neuritis, polyarthritis, hypo thyroidism and systemic lupus erythematodes. The pathogenesis and diagnosis of all cases are discussed
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