6 research outputs found
Transparent, crystalline ZnO thin films: Effect of spin coating parameters on the structural and optical properties
No full textNeutron Diffraction, Mossbauer and Electron Paramagnetic Resonance Studies of Pb0.8Bi0.2Fe0.6Nb0.4O3 Multiferroic
No full textThe Pb0.8Bi0.2Fe0.6Nb0.4O3 (PFN-BFO) multiferroic solid solution was synthesized by single step solid state reaction method with low calcination (700 degrees C/2h) and sintering (800 degrees C/3h) temperatures. Single phase formation was confirmed through X Ray Diffraction (XRD) and Neutron Diffraction (ND) at room temperature (RT). The structural analysis was carried out by Rietveld refinement through the Fullprof program. Refined XRD and ND patterns confirms the monoclinic structure with Cm space group and obtained cell parameters from the ND data are a = 5.6449(8) angstrom, b = 5.6536(5) angstrom, c = 4.0017(6) beta = 30(4). ND data at RT exhibits G-type antiferromagnetic structure. The Mossbauer and Electron Paramagnetic Resonance (EPR) spectroscopy studies were carried out at RT. The isomer shift and the quadrupole splitting of the Mossbauer spectra confirm the Fe in +3 states. An EPR spectrum shows a single broad slight asymmetric line, is an evidence of Fe in +3 states. ND, Mssbauer and EPR studies are the clear evidence of existence of antiferromagnetic ordering near room temperature
Evaluation of clopidogrel on acute and sub-acute models of inflammation in male Wistar rats
No full textBackground: Atherosclerosis and its complications remain the major cause of death and premature disability. Atherogenesis involves elements of inflammation, a process that now provides a unifying theme in the pathogenesis of the disease. Anti-platelet drugs are currently used in the treatment of atherosclerosis and its complications. Our study evaluated the influence of clopidogrel on acute and sub-acute models of inflammation in male Wistar rats.Methods: Male Wistar rats (150-200 g) were divided into three groups, i.e. control, aspirin and clopidogrel (n=6 animals in each group). The effect of clopidogrel administered orally on inflammation was studied using acute (carrageenan-induced rat paw edema) and sub-acute (cotton pellet granuloma and histopathological examination of grass piths) models. Experiment was conducted according to the Committee for the Purpose of Control and Supervision on Experiments on Animals guidelines. Analysis was done using one-way ANOVA followed by post-hoc test of Dunnets. p<0.05 was considered as statistically significant.Results: Clopidogrel showed significant inhibition of rat paw edema in acute model (p<0.01) and granuloma dry weight, in sub-acute model of inflammation when compared to control (p<0.01). Histopathological examination of grass pith revealed markedly reduced fibroblasts, granulation tissue, fibrous tissue and collagen in clopidogrel group when compared to control.Conclusion: Clopidogrel exhibited a significant anti-inflammatory activity in acute and sub-acute models of inflammation
Perception of 2nd-Year medical undergraduates regarding the implementation of competency-Based medical education in pharmacology
No full textObjectives: The purpose of the study was to understand the perception of 2nd-year medical undergraduates regarding the implementation of competency-based medical education (CBME) in pharmacology. Materials and Methods: This cross-sectional study was undertaken by the department of pharmacology, in our institution. Out of 197 s year medical undergraduate students, 192 provided their valuable feedback. The questionnaire consisted of three types of questions: (1) multiple-choice questions, (2) rating on a 5-point Likert scale, and (3) open-ended questions. In the open-ended questions, the students were asked to share their views. Responses to the questions were recorded. Students' “feedback responses” were scrutinized in terms of percentages. Conceptual content analysis was done for open-ended questions. Results: Students were satisfied with the implementation of CBME as well as the conduct of small group teaching, self-directed learning, integrated assessment, attitude, ethics, and communication skills, and pandemic modules. They emphasized more on game-based learning and other innovative teaching–learning methods that drove their interest to understand the subject better. Conclusion: Implementation of CBME has been found to be more effective than the traditional didactic approach
