51 research outputs found
Making cycles, bicycles and macrocycles
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
IL RUOLO DELLA SOSTENIBILITÀ PERCEPITA NELLO SVILUPPO DELLA FEDELTÀ AL RETAILER. UN’ANALISI SUI CONSUMATORI ITALIANI
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La tomografia a emissione di positroni (PET) con F-18 FDG nello studio delle formazioni espansive a sede surrenalica: confronto tra lesioni benigne e maligne
No full textIn this study, 15 patients (4 men and 11 women, mean age: 50 +/- 13 years) with unilateral adrenal masses detected on ultrasound (US), Computed Tomography (CT) and/or Magnetic Resonance (MR) studies were submitted to positron emission tomography (PET) with fluorine-18 deoxyglucose (FDG). Histology demonstrated 3 adenomas, 1 myelolipoma, 1 angiolipoma, 1 neurinoma, 1 cyst, 1 malignant pheochromocytoma, 4 carcinomas and 3 metastases. The patient population was divided into two groups. Group 1 (n = 7) consisted of benign adrenal lesions. Group 2 consisted of malignant adrenal tumors. Lesion measurements were performed on the basis of the results of US, CT and/or MR images. In Group 1, no FDG uptake was observed in adrenal masses. Conversely, in Group 2 adrenal lesions showed abnormally increased FDG uptake, suggesting high glucose tumor metabolism. No significant difference in lesion size was observed between Groups 1 and 2 (5.6 +/- 4.0 vs 6.3 +/- 3.0 cm). Furthermore, in 6 patients of Group 2, total body PET images showed abnormal FDG uptake in extra-adrenal locations, such as chest (n = 2) and abdominal (n = 5) lymph nodes, lungs (n = 6), liver (n = 5), pancreas (n = 1), bone (n = 1) and muscle (n = 1) tissues. In conclusion, the results of this study suggest that PET imaging with FDG can characterize adrenal masses. In particular, abnormally increased FDG uptake in adrenal malignancies allows to differentiate these abnormalities from benign lesions. Furthermore, total body imaging PET can identify extra-adrenal tumor sites in patients with malignant tumor
Copper-Catalyzed Decarboxylative C—N Cross-Coupling for N-Arylation
No full textA novel approach for N-arylation utilizing aryl carboxylic acids as stable, inexpensive and widely available arylating reagents was developed. Employing a simple copper(II)-phenanthroline catalyst system, several benzoic acids bearing suitable ortho-substitutions undergo decarboxylative C—N cross-coupling effectively with various N-nucleophiles
Evolution of a New Class of VEGFR‑2 Inhibitors from Scaffold Morphing and Redesign
No full textAnti-VEGF therapy is a clinically
validated treatment for age-related macular degeneration (AMD). We
have recently reported the discovery of oral VEGFR-2 inhibitors that
are selectively distributed to the ocular tissues. Herein we report
a further development of those compounds and in particular the validation
of the hypothesis that aminoheterocycles such as aminoisoxazoles and
aminopyrazoles could also function as effective “hinge”
binding moieties leading to a new class of KDR (kinase insert domain
containing receptor) inhibitors
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