1,116 research outputs found
Schmidt, Touch, Neitz, Neitz (2016). J Vis
No full textColor appearance, genetic and optical data. Notes: L cone sensitivities were based on the sequence of each subjects L pigment. Amino acids reported: exon 2—65, 111, 116; exon 3—153, 171, 174, 180; and exon 4—230, 233, 236. For females with two L sequences, the peak sensitivity of both pigments was averaged to compute the reported peak L cone sensitivity. All subjects had M cone peak values of 530 nm. All subjects identified as Caucasian except subjects U12 and U13, who were of Asian ethnicity.Data were published in the appendix of Schmidt, Touch, Neitz, Neitz (2016). "Circuitry to explain how the relative number of L and M cones shapes color experience." They published here for easier access.</div
B.S. Johnson and Maureen Duffy: Aspiring Writers: A Conversation with Maureen Duffy
No full textMaureen Duffy and B.S. Johnson met at King’s College London in 1956 when they both enrolled to read for a degree in English Literature. They became friends and colleagues through their contributions to Lucifer, the college literary magazine and the wider University of London poetry scene. They later joined forces in the Writer’s Action Group and campaigned for public lending rights for authors. Maureen kindly agreed to be interviewed about her relationship with Johnson, but in addition to this her interview sheds light on the socio-political context of British post-war writing. Maureen was born in 1933 in Worthing, Sussex and came to prominence in 1962 with the autobiographical novel That’s How It Was. Although mainly known for her poetry, her prose work has received critical and popular acclaim. Gor Saga (1981) was dramatised and broadcast by the BBC in 1988 as First Born, a three-part mini-series vehicle for Charles Dance. She is also the author of 16 plays for stage, television and radio. Maureen is well known as a humanist and gay rights activist and for her work championing the financial and legal interests of writers. She is currently the President of the Authors Licensing and Copyright Society, and a Fellow and Vice President of the Royal Society of Literature. This interview took place in London in July 2013 and first appeared in the inaugural edition of B.S.J: The B. S. Johnson Journal
Introduction
No full textIn the last four decades, southeastern archaeology has increasingly developed a processual method of looking at archaeological data through varying levels of scale. By adjusting the scale, archaeologists can further define societal interactions and exchanges, which is particularly useful to those researching the Mississippian period, as the rise and fall of chiefdoms was both internally complex and externally influenced by broader regional factors. This use of the most current research methods has enabled a more comprehensive understanding of prehistoric and historic sociopolitical entities.
In Archaeological Perspectives of the Southern Appalachians, Ramie A. Gougeon and Maureen S. Meyers have brought together a dozen archaeologists to delineate multiscalar approaches to Native American sites throughout southern Appalachia. The essays range in topic from ceramic assemblages in northern Georgia to public architecture in North Carolina to the frontiers of southern Appalachia in Virginia. Throughout the volume, the contributors discuss varying scales of analysis in their own research to flesh out the importance of maintaining different perspectives when evaluating archaeological evidence.
Additionally, the volume makes particular reference to the work of David Hally, whose influence on not only the editors and contributors but on southeastern archaeology as a whole cannot be overstated. While Hally was neither a pioneer nor vocal champion of scale variation, his impeccable research, culminating with the publication of his magnum opus King: The Social Archaeology of a Late Mississippian Town in Northwestern Georgia paved the way for younger scholars to truly develop research methods for holistic social archaeology.
Ramie A. Gougeon is an assistant professor with the Division of Anthropology and Archaeology at the University of West Florida. He has contributed chapters to Architectural Variability in the Southeast and Ancient Households of the Americas .
Maureen S. Meyers is an assistant professor in the Department of Sociology and Anthropology at the University of Mississippi. Her articles have appeared in Southeastern Archaeology, Native South, and the anthology Mapping the Mississippian Shatter Zone.publishedIntroductio
Spectral tuning of ultraviolet cone pigments: An interhelical lock mechanism
No full textUltraviolet (UV) cone pigments can provide insights into the molecular evolution of vertebrate vision since they are nearer to ancestral pigments than the dim-light rod photoreceptor rhodopsin. While visible-absorbing pigments contain an 11-cis retinyl chromophore with a protonated Schiff-base (PSB11), UV pigments uniquely contain an unprotonated Schiff-base (USB11). Upon F86Y mutation in model UV pigments, both the USB11 and PSB11 forms of the chromophore are found to coexist at physiological pH. The origin of this intriguing equilibrium remains to be understood at the molecular level. Here, we address this phenomenon and the role of the USB11 environment in spectral tuning by combining mutagenesis studies with spectroscopic (UV-vis) and theoretical [DFT-QM/MM (SORCI+Q//B3LYP/6-31G(d): Amber96)] analysis. We compare structural models of the wild-type (WT), F86Y, S90A and S90C mutants of Siberian hamster ultraviolet (SHUV) cone pigment to explore structural rearrangements that stabilize USB11 over PSB11. We find that the PSB11 forms upon F86Y mutation and is stabilized by an "inter-helical lock" (IHL) established by hydrogen-bonding networks between transmembrane (TM) helices TM6, TM2, and TM3 (including water w2c and amino acid residues Y265, F86Y, G117, S118, A114, and E113). The findings implicate the involvement of the IHL in constraining the displacement of TM6, an essential component of the activation of rhodopsin, in the spectral tuning of UV pigments. © 2013 American Chemical Society
Kongsberg Vision Meeting 2008
No full textKongsberg Vision Meeting was arranged at Buskerud University College in Kongsberg for the third time on October 13, 2008. Rigmor C. Baraas organized the meeting. Keynote speakers were Jay Neitz and Maureen Neitz from the Medical College of Wisconsin, Milwaukee, USA
Data protection: the challenges facing social networking
No full textThe popularity of social networking sites has increased dramatically over the past decade. A recent report indicated that thirty-eight percent of online users have a social networking profile. Many of these social networking site users (SNS users) post or provide personal information over the internet every day. According to the latest OfCom study, the average adult SNS user has profiles on 1.6 sites and most check their profiles at least once every other day. However, the recent rise in social networking activity has opened the door to the misuse and abuse of personal information through identity theft, cyber stalking, and undesirable screenings by prospective employers. Behavioral advertising programs have also misused personal information available on social networking sites. Society is now facing an important question: what level of privacy should be expected and required within the social networking environment
Effects of deleterious opsin gene variants on cone photoreceptor structure, function, and viability
No full textThesis (Ph.D.)--University of Washington, 2013Specific L/M-opsin interchange variants have recently been linked to a variety of eye disorders that include diminished ERGs, color blindness, and pathologically high myopia. One disease-causing variant, designated LVAVA according to its defining amino acid sequence, has been linked to two distinct vision disorders. Males with LVAVA in one of the first two positions in the X-chromosome opsin gene array develop pathologically high myopia and have abnormal ERGs, while those with an LVAVA variant as their only X-chromosome opsin gene have extreme and uncorrectable vision loss. In this dissertation, retinal function was measured by ERG in two men with the latter, non-syndromic disease. While cones expressing the LVAVA opsin were physiologically compromised, residual function was maintained into adulthood. Furthermore, these cones disrupted the function of neighboring S cones that did not harbor the toxic variant. In order to directly test the relationship between the LVAVA variant and pathology, the non-syndromic disease was modeled in a targeted gene replacement mouse in which the endogenous Opn1mw gene was exchanged for an engineered Opn1lwLVAVA gene. Because the presence of S-opsin in coexpressing mouse cones could interfere with the experiments, the Opn1sw genes were knocked out of both the LVAVA mice and the control mice that expressed a functional human opsin (LIAIS). ERG and histological experiments demonstrated that the mouse model faithfully recapitulated functional and morphological retinal defects associated with the human disease. Another variant, referred to as LIAVA, completely and selectively disrupts the function of cones that express it. Retinal function was evaluated by ERG in a subject who was previously reported to express an LIAVA variant in all of his L/M cones. The human data were compared to ERG and retinal morphology data collected from an Opn1lwLIAVA Opn1sw-/- mouse model that exhibited a late-onset and relatively mild phenotype. While the results from mice demonstrated that the LIAVA amino acid sequence is directly harmful to cones, the source of dysfunction in human cones likely arises from aberrant splicing of the LIAVA messenger RNA due to the nucleotide haplotype of exon 3 associated with this amino acid combination. The S-opsin knockout mouse line that provided the genetic background for all mice used in the LVAVA and LIAVA studies was generated using targeted gene replacement technology, and the effects of removing S-opsin from cones that would otherwise coexpress both S and M/L-opsins were investigated. In addition to making the interpretation of data collected from the disease models more straightforward, characterizing the€ Opn1mw Opn1sw-/- mice and the Opn1lwLIAIS Opn1sw-/- mice provided insights into issues relating to visual adaptation, regulation of opsin gene expression, and cone viability
Introduction to Hospitality & Tourism
No full textAn OER text for created to support Hospitality and Tourism courses at Dutchess Community College. Written, compiled, and designed by Maureen Peters Gittelman.NASUNY DutchessBusiness, Aviation & Construction ProfessionsN/
Open Access: What is the Climate for OA Publishing and Institutional Repositories in Ohio in 2016?
No full textPresentation by Maureen Schlangen of the University of Dayton makes a case for a survey of faculty at Ohio institutions to gauge openness to Open Access archiving and publishing. Those interested in conducting the survey on their campuses are invited to contact the author using the email provided
- …
