1,985 research outputs found
Assessing the George W. Bush Presidency: A Tale of Two Terms
No full textIn one of the first volumes assessing the full two terms of the George W. Bush presidency, Wroe and Herbert have gathered the work of leading American and European scholars. In fifteen succinct and incisive chapters, authorities such as Jim Pfiffner, John Maltese, Graham Wilson and Alan Gitelson offer assessments of the Bush administration's successes and failures. Extensive attention is paid to Bush's foreign policy, including 'The War on Terror' but the focus is broadened to absorb not only the Bush Doctrine and its repercussions, but also his trade and homeland security policies. The president's domestic leadership in economics and social policy is investigated, as are his dealings as president with the other institutions of the U.S. political system. The result is a comprehensive guide to the Bush presidency and its legacy
Southern portion of Graham Island, Queen Charlotte Islands, British Columbia.
No full textgeology, J.D. Mackenzie ; geography, British Admiralty and Department of the Naval Service of Canada, Department of Lands, British Columbia, J.D. MacKenzie ; C.O. Senecal, geographer and chief draughtsman.Scale 1:126,720. 2 miles to 1 in. (W 132 24'-W 131 55'/N 53 45'-N 53 08'). Contours shown by spot heights. Includes marginal notes and location map. Includes cross-sections and geological notes. Geology, published charts, township plans and surveys, conducted 1913-1914. To accompany Memoir by J.D. MacKenzie, Geology of Graham Island, British Columbia
GLI1 confers profound phenotypic changes upon LNCaP prostrate cancer cells that include the acquisition of a hormone independent state
No full textThe GLI (GLI1/GLI2) transcription factors have been implicated in the development and progression of prostate cancer although our understanding of how they actually contribute to the biology of these common tumours is limited. We observed that GLI reporter activity was higher in normal (PNT-2) and tumourigenic (DU145 and PC-3) androgen-independent cells compared to androgen-dependent LNCaP prostate cancer cells and, accordingly, GLI mRNA levels were also elevated. Ectopic expression of GLI1 or the constitutively active ?NGLI2 mutant induced a distinct cobblestone-like morphology in LNCaP cells that, regarding the former, correlated with increased GLI2 as well as expression of the basal/stem-like markers CD44, ?1-integrin, ?Np63 and BMI1, and decreased expression of the luminal marker AR (androgen receptor). LNCaP-GLI1 cells were viable in the presence of the AR inhibitor bicalutamide and gene expression profiling revealed that the transcriptome of LNCaP-GLI1 cells was significantly closer to DU145 and PC-3 cells than to control LNCaP-pBP (empty vector) cells, as well as identifying LCN2/NGAL as a highly induced transcript which is associated with hormone independence in breast and prostate cancer. Functionally, LNCaP-GLI1 cells displayed greater clonal growth and were more invasive than control cells but they did not form colonies in soft agar or prostaspheres in suspension suggesting that they do not possess inherent stem cell properties. Moreover, targeted suppression of GLI1 or GLI2 with siRNA did not reverse the transformed phenotype of LNCaP-GLI1 cells nor did double GLI1/GLI2 knockdowns activate AR expression in DU145 or PC-3 cells. As such, early targeting of the GLI oncoproteins may hinder progression to a hormone independent state but a more detailed understanding of the mechanisms that maintain this phenotype is required to determine if their inhibition will enhance the efficacy of anti-hormonal therapy through the induction of a luminal phenotype and increased dependency upon AR function
Provenance of impure calclithites in the Laramide foreland of southwestern Montana
No full textThe Sphinx Conglomerate is an uppermost Cretaceous and Paleocene(?) synorogenic clastic wedge derived from a Laramide uplift in southwestern Montana. Conglomerate petrology documents unroofing of the thick Phanerozoic section that covered the uplift. The active tectonic setting resulted in close correspondence between source lithologies and derived conglomerates and sandstones. Sandstone detrial modes determined using the Gazzi-Dickinson point-counting method further document the unroofing sequence -from Author
The sexual excitation/sexual inhibition inventory for women: psychometric properties
No full textThis is a post-print version of the article. The official published version can be found at the link below.This article reports on the development of a new questionnaire designed to assess the propensity for sexual excitation and sexual inhibition in women: The Sexual Excitation/Sexual Inhibition Inventory for Women (SESII-W). The theoretical model underlying this research, the Dual Control Model, postulates that sexual response depends on a balance between excitatory and inhibitory mechanisms and that individuals vary in their propensity for excitation and inhibition. This study describes the development and initial validation of the SESII-W in a sample of 655 women (M age, 33.9 years). Factor analysis identified eight factors and two higher-order factors: one related to sexual excitation and one to sexual inhibition. The measure demonstrated good test-retest reliability and discriminant and convergent validity. Our data underscore that a number of factors affect women's sexual arousal and these appear to be related to opposing processes of sexual excitation and sexual inhibition. Theoretical issues, possible gender differences, and the value of using qualitative data to inform questionnaire development are discussed.This study was funded, in part, by a grant from the Lilly Centre for Women‟s Health
The DSM diagnostic criteria for female orgasmic disorder
No full textThis is the post-print version of the article. The official published version can be found at the link below.This article reviews the DSM diagnostic criteria for Female Orgasmic Disorder (FOD). Following an overview of the concept of female orgasm, research on the prevalence and associated features of FOD is briefly reviewed. Specific aspects of the DSM-IV-TR criteria for FOD are critically reviewed and key issues that should be considered for DSM-V are discussed. The DSM-IV-TR text on FOD focused on the physiological changes that may (or may not) accompany orgasm in women; one of the major recommendations here is that greater emphasis be given to the subjective aspects of the experience of orgasm. Additional specific recommendations are made for revision of diagnostic criteria, including the use of minimum severity and duration criteria, and better acknowledgment of the crucial role of relationship factors in FOD
Réplica a Graham Murdock
No full textIn this text Smythe defends himself from accusations made by Graham Murdock about his analysis of the deficiencies of Western Marxism in its study of communications (see abstract of last article). The author accuses Murdock of reductionism and Eurocentered tendencies, and defends his own point of view analyzing and answering to every critical assertion made to his work. Finally he suggests the need of questioning and re-examining the European tradition, anchored in class conceptions and hierarchical organizational structures, preconceptions which have caused the blindspots in what has to do with consciousness industry and ideology.En este texto Smythe se defiende de las acusaciones vertidas por Graham Murdock respecto de su análisis sobre las deficiencias del marxismo occidental a la hora de abordar el estudio de las comunicaciones (ver abstract del artículo anterior). El autor acusa asimismo a Murdock de reduccionista y eurocentrista, y defiende su postura anterior analizando y respondiendo a todas y cada una de las críticas planteadas a su trabajo. Por último sugiere la necesidad de cuestionar y reexaminar la tradición europea, anclada en concepciones de clase y estructuras de organización jerárquicas, preconcepciones que precisamente han producido el agujero negro en lo que se refiere a la industria de la conciencia y la ideología
Whose Man in Havana? Adventures from the Far Side of Diplomacy
No full textIn Whose Man in Havana? the author offers an unconventional, often dark, but more often hilarious view of diplomacy in settings as varied as Haiti, London, the Dominican Republic, the Balkans, Palestine, Paraguay, Guyana, and Kyrgyzstan, including covert monitoring of Soviet military operations in Cuba on behalf of the CIA with the blessing of President Kennedy and Prime Minister Pearson. In a career that spans the Canadian foreign service and international organizations, he was fortunate to be in the right place at interesting, if turbulent, times. Throughout the book he has focussed on the lighter side of people and places, but almost everywhere the dark side intrudes. Graham makes plain that the intersection of the two is frequently black comedy
Whose Man in Havana? Adventures from the Far Side of Diplomacy
No full textIn Whose Man in Havana? the author offers an unconventional, often dark, but more often hilarious view of diplomacy in settings as varied as Haiti, London, the Dominican Republic, the Balkans, Palestine, Paraguay, Guyana, and Kyrgyzstan, including covert monitoring of Soviet military operations in Cuba on behalf of the CIA with the blessing of President Kennedy and Prime Minister Pearson. In a career that spans the Canadian foreign service and international organizations, he was fortunate to be in the right place at interesting, if turbulent, times. Throughout the book he has focussed on the lighter side of people and places, but almost everywhere the dark side intrudes. Graham makes plain that the intersection of the two is frequently black comedy
The DSM diagnostic criteria for Female Sexual Arousal Disorder
No full textThis article reviews and critiques the DSM-IV-TR diagnostic criteria for Female Sexual Arousal Disorder (FSAD). An overview of how the diagnostic criteria for FSAD have evolved over previous editions of the DSM is presented and research on prevalence and etiology of FSAD is briefly reviewed. Problems with the essential feature of the DSM-IV-TR diagnosis — “an inability to attain, or to maintain…an adequate lubrication-swelling response of sexual excitement” — are identified. The significant overlap between “arousal” and “desire” disorders is highlighted. Finally, specific recommendations for revision of the criteria for DSM-V are made, including use of a polythetic approach to the diagnosis and the addition of duration and severity criteria
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