447 research outputs found
The Spruce Street Tragedy; or, Old Spicer Handles a Double Mystery / by the Author of "Old Spicer".
No full textIDEAS project - Private sector health data sharing study in Uttar Pradesh
No full textThe IDEAS project sought to improve the health and survival of mothers and babies through generating evidence to inform policy and practice. This data collection contains expanded field notes of face-to-face, semi-structured interviews conducted with 48 purposively selected key informants in Lucknow, Allahabad and Hardoi as part of a rapid assessment to determine private sector barriers and enablers associated with the sharing of maternal and newborn health data with the public sector. It also includes photographs of example health records, study tools, and associated documentation
IDEAS project - Scaling-up innovations to improve maternal and newborn health - Uttar Pradesh case study resources
No full textThe IDEAS project sought to improve the health and survival of mothers and babies through generating evidence to inform policy and practice in Ethiopia, northeast Nigeria and Uttar Pradesh, India. This data collection contains interview field notes and supporting information produced as part of a case study to document and assess the process by which the State Government of Uttar Pradesh introduced and scaled-up mSehat, a mobile phone application used by community health workers (Accredited Social Health Activists (ASHAs)) to create and maintain electronic health records
IDEAS project - Scaling-up innovations to improve maternal and newborn health - Ethiopia case study resources
No full textThe IDEAS project sought to improve the health and survival of mothers and babies through generating evidence to inform policy and practice in Ethiopia, northeast Nigeria and Uttar Pradesh, India. This data collection contains interview field notes and supporting information produced as part of a case study to determine what had catalysed, helped and hindered the scale-up of antibiotic administration by health extension workers treating newborn sepsis in Ethiopia. This innovation, which had originated from the Community Based Interventions for Newborns in Ethiopia (COMBINE) project and been evaluated through a randomised control trial, had at the time of this study, been scaled-up to 92 woredas as one of nine components of the first phase of the Ethiopian Government’s Community Based Newborn Care package (CBNC)
A matter of thousands, or, Blocking a "skin" game / by the author of "Old Spicer," "The sport of fate," etc.
No full textIDEAS project - Scaling-up innovations to improve maternal and newborn health - Nigeria case study resources
No full textThe IDEAS project sought to improve the health and survival of mothers and babies through generating evidence to inform policy and practice in Ethiopia, northeast Nigeria and Uttar Pradesh, India. This data collection contains interview field notes and supporting information produced as part of a case study to investigate how an emergency transport scheme for pregnant women and newborn babies introduced in Gombe state had been scaled up to Adamawa state by Transaid and the Society for Family Health, working with National Union of Transport Workers
Measurement, learning and evaluation for maternal and newborn health - IDEAS satellite session presentation at the Fourth Global Symposium on Health Systems Research
No full textAt the Fourth Global Symposium on Health Systems Research in Vancouver IDEAS organised a special Satellite Session on the topic of 'Measurement, learning and evaluation for maternal and newborn health'.
Chaired by:
Joanna Schellenberg (IDEAS) and John Grove (Bill and Melinda Gates Foundation)
Panellists:
Wuleta Betemariam
Project Director - Last Ten Kilometers Project
John Snow Inc. Ethiopia
Lynn Freedman
Director - The Averting Maternal Death and Disability Programme (AMDD)
Mailman School of Public Health
Department of Population and Family Health
Columbia University
Pinki Maji
Senior Program Manager - Implementation
Population Services International - India
Magdalene Okolo
Project Director - Maternal and Neonatal Health Care Project
Society for Family Health - Nigeria
Presentations and debate sessions:
(1) The Mechanisms of Change with Krystyna Makowiecka
(2) Data Driven Action with Tanya Marchant
(3) Scaling-Up Innovations with Neil Spicer
(4) District Level Data for Decision Making with Bilal Avan
More info: http://bit.ly/MLE4MNC
Catalysing scale-up of people-centred maternal and newborn health innovations within the health systems of Ethiopia, Uttar Pradesh, India and northeast Nigeria: building a conceptual framework
No full textDr Tanya Marchant presented on behalf of Dr Neil Spicer, IDEAS Qualitative Lead on Scale-up, on catalysing scale-up of people-centred maternal and newborn health innovations within the health systems of Ethiopia, Uttar Pradesh, India and northeast Nigeria: building a conceptual framework. The presentation was based on qualitative work from the IDEAS project.
Summary
The presentation proposed a framework of actions to catalyse scale-up of maternal and newborn health innovations and the following policy actions for different groups:
Government
Work closely with grantees: maximise relevance and value
Strengthen partner coordination: exchanging and capturing learning
Donors
Insist grantees integrate scale-up plans within their programmes
Finance, incentivise, and strengthen grantee capacity to catalyse scale-up
Finance grantees to support and enable government to scale innovations
Grantees
Integrate scale-up plans within programme design
Commit to exchanging learning and coordinating with other programmes
Communities
Work with grantees to propagate innovation diffusio
Biophysical survey of small-molecule β-catenin inhibitors: a cautionary tale
No full textThe canonical Wingless-related integration site signaling pathway plays a critical role in human physiology, and its dysregulation can lead to an array of diseases. β-Catenin is a multifunctional protein within this pathway and an attractive yet challenging therapeutic target, most notably in oncology. This has stimulated the search for potent small-molecule inhibitors binding directly to the β-catenin surface to inhibit its protein-protein interactions and downstream signaling. Here, we provide an account of the claimed (and some putative) small-molecule ligands of β-catenin from the literature. Through in silico analysis, we show that most of these molecules contain promiscuous chemical substructures notorious for interfering with screening assays. Finally, and in line with this analysis, we demonstrate using orthogonal biophysical techniques that none of the examined small molecules bind at the surface of β-catenin. While shedding doubts on their reported mode of action, this study also reaffirms β-catenin as a prominent target in drug discovery
Benthic assemblages of the Anton Dohrn seamount (NE Atlantic): defining deep-sea biotopes to support habitat mapping and management efforts with a focus on vulnerable marine ecosystems
No full textIn 2009 the NW and SE flanks of Anton Dohrn Seamount were surveyed using multibeam echosounder and video ground-truthing to characterise megabenthic biological assemblages (biotopes) and assess those which clearly adhere to the definition of Vulnerable Marine Ecosystems, for use in habitat mapping. A combination of multivariate analysis of still imagery and video ground-truthing defined 13 comprehensive descriptions of biotopes that function as mapping units in an applied context. The data reveals that the NW and SE sides of Anton Dohrn Seamount (ADS) are topographically complex and harbour diverse biological assemblages, some of which agree with current definitions of ‘listed’ habitats of conservation concern. Ten of these biotopes could easily be considered Vulnerable Marine Ecosystems; three coral gardens, four cold-water coral reefs, two xenophyophore communities and one sponge dominated community, with remaining biotopes requiring more detailed assessment. Coral gardens were only found on positive geomorphic features, namely parasitic cones and radial ridges, found both sides of the seamount over a depth of 1311–1740 m. Two cold-water coral reefs (equivalent to summit reef) were mapped on the NW side of the seamount; Lophelia pertusa reef associated with the cliff top mounds at a depth of 747–791 m and Solenosmilia variabilis reef on a radial ridge at a depth of 1318-1351 m. Xenophyophore communities were mapped from both sides of the seamount at a depth of 1099–1770 m and were either associated with geomorphic features or were in close proximity (< 100 m) to them. The sponge dominated community was found on the steep escarpment either side of the seamount over at a depth of 854-1345 m. Multivariate diversity revealed the xenophyophore biotopes to be the least diverse, and a hard substratum biotope characterised by serpulids and the sessile holothurian, Psolus squamatus, as the most diverse
- …
