350 research outputs found
Biomaterials based strategies for engineering tumor microenvironment
No full textTissue engineering aims to gain mechanistic insights into human diseases and to develop new treatment protocols. Although 2-dimensional (2-D) flat petri dish culture and in vivo disease-based models are the industrial gold standards for understanding the underlying disease pathophysiology and for drug screening/testing, they are associated with certain limitations. While the 2-D cell culture systems fail to mimic in vivo signaling, animal-based disease models are associated with long incubation period, high cost, ethical constraints as well as depiction of human pathology in different species. Therefore, there has been a paradigm shift towards the development of 3-dimensional (3-D) based in vitro disease models. These models act as bridging gaps between the aforementioned conventional strategies thereby fastening clinical translation. In this regard, biomedical engineering plays a key role towards the development of tissue engineering based 3-D disease models. These models have demonstrated success in recapitulating human diseases in terms of in vivo morphology and signaling. This chapter will present examples of biomaterials-based 3-D engineered disease models with a focus on cancer
Hölder continuity and Harnack estimate for non-homogeneous parabolic equations
No full textIn this paper we continue the study on intrinsic Harnack inequality for non-homogeneous parabolic equations in non-divergence form initiated by the first author in Arya (Calc Var Partial Differ Equ 61:30–31, 2022). We establish a forward-in-time intrinsic Harnack inequality, which in particular implies the Hölder continuity of the solutions. We also provide a Harnack type estimate on global scale which quantifies the strong minimum principle. In the time-independent setting, this together with Arya (2022) provides an alternative proof of the generalized Harnack inequality proven by the second author in Julin (Arch Ration Mech Anal 216:673–702, 2015).peerReviewe
Arya Stark, donzela-guerreira?
No full textThis article addresses in its content an analysis on the character Arya Stark of the literary work, the chronicles of Ice and Fire, of the author George R.R. Martin. For this, the study was directed by the study about gender (GALVÃO, 1998), namely, the understanding of the term damsel-warrior and its importance in relation to social issues pertinent to female experience, especially in the literary description. The purpose of analyzing the character is to establish a debate about the feminine 'image' in the work, through Arya and a comparison with the experience of the woman in the contemporary society, being, therefore, the theoretical concepts, through bibliographical revision On the ethos (AMOSSY, 2014, EGGS, 2014) and the enunciative scene (MAINGUENAU, 2014) help in the argumentative constitution for a better understanding of the discursive types that are in the social core historically and that reflect in the analyzed work. The result of the research, from the studies of the theoretical basis, was convergent to elucidation of the social constitution that the discourse has. Thus, it is relevant to note that understanding how discourses are defined and expressed through literature continues to reveal the barriers that result in occasional domains of groups over others.Este artigo aborda em seu conteúdo uma análise sobre a personagem Arya Stark da obra literária, As crônicas de Gelo e Fogo, do autor George R.R. Martin. Para tanto, o estudo foi direcionado pelo estudo a respeito de gênero (GALVÃO, 1998), a saber, sobre a compreensão do termo donzela-guerreira e de sua importância frente às questões sociais pertinentes a vivência feminina, sobretudo na tradição literária. O propósito de analisar a personagem é de estabelecer um debate a respeito da ‘imagem’ feminina na obra, por meio de Arya e de uma comparação com a vivência da mulher na sociedade contemporânea, sendo assim, os conceitos teóricos, por meio de revisão bibliográfica sobre ethos (AMOSSY, 2014; EGGS, 2014) e da cena enunciativa (MAINGUENAU, 2014) auxiliam na constituição argumentativa para melhor compreensão dos tipos discursivos que estão no cerne social historicamente e que refletem na obra analisada. O resultado da pesquisa, a partir dos estudos da base teórica, foi convergente a elucidação da constituição social que o discurso tem frente à temática. Dessa forma, mostra-se relevante pontuar que compreender como os discursos são definidos e expressos através da literatura continua a revelar os entraves que resultam em ocasionais domínios de grupos sobre outros
Poly(d,l-lactide-co-glycolide)–chitosan composite particles for the treatment of lung cancer
No full textNeha Arya, Dhirendra S Katti Department of Biological Sciences and Bioengineering, Indian Institute of Technology – Kanpur, Kanpur, Uttar Pradesh, India Abstract: Tumor heterogeneity makes combination chemotherapy one of the preferred modes of treatment regimens. In this work, sequential exposure of two anticancer agents, paclitaxel (Tx) followed by topotecan (TPT), was shown to have a synergistic effect on non-small cell lung cancer (NSCLC) cell line, NCI-H460. In order to improve patient compliance, the aforementioned concept was translated into a drug delivery system comprising of poly(d,l-lactide-co-glycolide) (PLGA)–chitosan composite particles. TPT-containing chitosan micro-/nanoparticles were prepared by the facile technique of electrospraying and encapsulated within PLGA microparticles using emulsion-solvent evaporation technique for delayed release of TPT. The formulation containing Tx- and TPT-loaded composite particles demonstrated synergism when exposed to NCI-H460 cellular aggregates (tumoroids) generated in vitro. Overall, the results of this study demonstrated the potential of the formulation containing Tx and PLGA–chitosan (TPT-loaded) composite particles for the treatment of lung cancer. Keywords: drug delivery system, solid tumor, paclitaxel, topotecan, sequential admini­stratio
Perancangan dan Penerapan Metode K-Means untuk Memprediksi Penjualan Toko Arya Elektrik
No full textIn a shop, the product is a staple that is sold and bought. There are products in the store between products that sell well and products that don't sell. Given this problem, it is necessary to create a system that can classify products that sell, products that sell well, and products that don't sell well, which was carried out at the Arya Elektrik Store and carried out from March to July 2022. The K-Means algorithm is not affected by the order of objects used. used, this is proven when the author tries to randomly determine the starting point of the cluster center of one of the objects at the start of the calculation. The number of cluster memberships generated is the same when using another object as the starting point for the cluster center. However, this only affects the number of iterations performed. The purpose is to create applications and analyze product sales at the Arya Elektrik Store using the K-Means method. With this system, it can provide convenience benefits for analyzing the grouping of product sales at the Arya Elektrik Store, determining and classifying product sales that are selling well, very selling, and less selling. The method used to collect data is observation and interviews. With this application, shop owners can see the results of grouping these products. So, if there are products that don't sell well, shop owners can look for other alternatives so that products that don't sell can be sold.Pada sebuah toko, produk merupakan bahan pokok yang dijual belikan. Produk di toko terdapat antara produk yang laku dengan produk yang tidak laku. Dengan adanya masalah ini, perlu untuk menciptakan sistem yang dapat mengelompokkan produk laku, produk sangat laku, dan produk yang kurang laku, yang dilakukan di Toko Arya Elektrik dan dilaksanakan pada bulan Maret sampai Juli 2022. Algoritma K-Means tidak terpengaruh terhadap urutan objek yang digunakan, hal ini dibuktikan ketika penulis mencoba menentukan secara acak titik awal pusat cluster dari salah satu objek pada permulaan perhitungan. Jumlah keanggotaan cluster yang dihasilkan berjumlah sama ketika menggunakan objek yang lain sebagai titik awal pusat cluster tersebut. Namun, hal ini hanya berpengaruh pada jumlah iterasi yang dilakukan. Tujuan untuk membuat aplikasi dan menganalisis penjualan produk pada Toko Arya Elektrik menggunakan metode K-Means. Dengan adanya sistem ini dapat memberikan manfaat kemudahan untuk menganalisis pengelompokkan penjualan produk pada Toko Arya Elektrik, menentukan dan mengklasifikasikan penjualan produk yang laku, sangat laku, dan kurang laku. Metode yang digunakan pengumpulan data adalah observasi dan wawancara. Dengan adanya aplikasi ini, pemilik toko dapat melihat hasil pengelompokkan produk tersebut. Maka, bila terdapat produk yang tidak laku, pemilik toko dapat mencari alternative lain agar produk yang tidak laku dapat menjadi laku.
Kata kunci: K-means, Produk, Klaste
To determine attitude, comfortability and challenges faced by undergraduate dental students during online classes
No full textContext: Amid the COVID-19 Pandemic, the education system swiftly shifted to online mode. Aims: To understand the attitude, comfortability, challenges, and health issues faced by dental students during online classes. Settings and Design: A cross-sectional survey was conducted among dental undergraduate students in Haryana. Materials and Methods: A self-designed questionnaire survey form having five sections and 28 questions was used. Statistical Analysis Used: The content validity index was 0.88. Cronbach's alpha coefficient for attitude was 0.844, and 0.905 for health issues. Descriptive statistics and frequency distribution were studied. Results: The response rate was 94.25%. Most students reported that they find it difficult to concentrate during online classes and strongly agreed that learning is better during offline classes. Practical classes were a bigger challenge in online mode. Conclusions: The majority of students preferred offline classes to online classes
Francis Bacon: Painting in A Godless World
No full textThroughout his career, Francis Bacon (1909-1992) made many anti-religious and, more specifically, anti-Christian statements. Bacon was a militant atheist but his atheism was not a simple dismissal of religion and religious belief. He exploited the symbols of Christianity, especially the Crucifixion and the Pope, in order to show its untenability in the modern age. Setting out to account for Bacon's recurrent and sustained use of religious symbols, Rina Arya explains how the artist redeployed religious iconography to convey an experience of the human condition, specifically animalism and mortality. By placing the work within the context of post-war philosophical pre-occupations with the death of God, the author provides a robust framework in which to view and interpret Bacon's complex images. Refreshingly original, this book marks a new approach to appreciating the work of one of the leading artists of the twentieth century
Francis Bacon: Painting in A Godless World
No full textThroughout his career, Francis Bacon (1909-1992) made many anti-religious and, more specifically, anti-Christian statements. Bacon was a militant atheist but his atheism was not a simple dismissal of religion and religious belief. He exploited the symbols of Christianity, especially the Crucifixion and the Pope, in order to show its untenability in the modern age. Setting out to account for Bacon's recurrent and sustained use of religious symbols, Rina Arya explains how the artist redeployed religious iconography to convey an experience of the human condition, specifically animalism and mortality. By placing the work within the context of post-war philosophical pre-occupations with the death of God, the author provides a robust framework in which to view and interpret Bacon's complex images. Refreshingly original, this book marks a new approach to appreciating the work of one of the leading artists of the twentieth century
The Speaking Body: Corporeal Symbolism in Arya Gopi's Poetry
No full textPoetry is an amalgam of both melancholy and bliss for Dr. Arya Gopi. She is an Indian bilingual writer who handles a wide variety of themes, the analysis of which would perhaps be a herculean task for a scholar. Her poetry contains everything. It speaks of inner and outer conflicts. It addresses intricacies of human psyche; confronts with life and death alike. Seldom do her words wither to be of a particular theme; instead it embraces everything general. Gopi\u27s collection of poems, Sob of Strings (2016) reveals her keen observation and unique poetic techniques. Her poetry can perhaps be considered synonymous with several of the confessional poems of Sylvia Plath, Emile Dickinson and Kamala Das. Basic human emotions, life, death, nature and the like never really are redshirts here. Another significant aspect of Gopi\u27s poetry must be the vitality of corporeal imagery made use of in Sob of Strings. Body can best used in theatre rather than literature, however, systematic development of bodily symbolism can make a work of literature complete. Body plays a vital role in meaning-making, which is a complex process. Plath and Emile Dickinson have constantly made use of several body centred symbols in order to depict intricacies of the human psyche. So does the author of Sob of Strings. Her poetry thus is a celebration of versatile themes, to justify which the author, without deliberate interruption, uses a handful of corporeal symbols
DNA Origami and its Applications in Therapeutics
No full textAbstract: DNA is a stable and biocompatible molecule due to its chemical and physical properties. Recent advancements in DNA nanotechnology allow the application of DNA origami nanostructures in a wide range of biomedical settings. The methods for the design, synthesis and analysis of DNA origami nanostructures are discussed in this study. One of the major applications of DNA nanotechnology is in therapeutics, as a delivery vehicle for chemotherapeutic drugs (such as doxorubicin and daunorubicin), as well as applications in photothermal and photodynamic therapy, all of which are discussed in this study. The study also discusses design parameters that need to be taken into consideration for the suitability and efficacy of the DNA origami nanostructures for different therapeutic functions.
Keywords: DNA origami, Nanostructures, Drug delivery, Photothermal, Photodynamic.
Title: DNA Origami and its Applications in Therapeutics
Author: Arya Mosahab
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
Vol. 11, Issue 1, January 2023 - March 2023
Page No: 79-85
Research Publish Journals
Website: www.researchpublish.com
Published Date: 23-March-2023
DOI: https://doi.org/10.5281/zenodo.7763114
Paper Download Link (Source)
https://www.researchpublish.com/papers/dna-origami-and-its-applications-in-therapeuticsInternational Journal of Life Sciences Research, ISSN 2348-313X (Print), ISSN 2348-3148 (online), Research Publish Journals, Website: www.researchpublish.co
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