1,720,974 research outputs found

    Disopyramide-induced neuropathy

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    Neuropathies are well-known complications of therapy with amiodarone, but other antiarrhythmic drugs are rarely associated with peripheral nervous system side effects. We describe a patient who developed a severe sensory-motor neuropathy during treatment with disopyramide. The neuropathy was unresponsive to corticosteroids, but improved after withdrawing disopyramide. This is, to our knowledge, the second case of disopyramide-induced neuropathy

    Oculo cranio-somatic syndrome: mitochondrial alterations and lactic acidemia

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    We studied three patients whose main symptoms were ptosis, external ophthalmoplegia and variable weakness of various facial and somatic muscles. In two of the patients we found lactic acidosis at rest, and an excessive production of lactic acid after 15 minutes of exercise. Ischemic exercise resulted in sustained blood lactate elevation in one of the patients while lactate returned to normal in the others. The pathogenesis of this lactic acidosis is examined on the basis of ultrastructural alterations and by comparison with recent experiments. We concluded that the morphological and biochemical changes found in our patients are due to a condition of relative ischemia in the muscles
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