554 research outputs found
Perceptions of wildland fire smoke : literature synthesis
No full textAutumn Ellison, Heidi Huber-Stearns, Stacey Sargent Frederick, Michael R. Coughlan, Sarah McCaffrey, and Christine S. Olsen.Title from PDF cover (viewed on July 22, 2021).This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references (pages 23-25).This synthesis was made possible with funds from the Joint Fire Science Program and the University of Oregon. It is a Northwest Fire Science Consortium product that was created over several years with initial input from scholars involved in JFSP Project #10-1-03-7.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
The evaluation of melamine dendrimers as potential macromolecular vehicles for anticancer drug delivery
No full textOften associated with chemotherapy are the dangerous and sometimes lifethreatening
side effects towards non-cancerous tissue that can occur while on such drug
regimens. The design and utilization of macromolecular drug delivery vehicles is
gaining much attention because the vascular system of tumor tissue possesses properties
that make it permeable to macromolecules. The attachment or encapsulation of
anticancer drugs to macromolecules can be used to selectively deliver these drugs to
tumor tissue thereby minimizing the toxic effects towards healthy tissue while
specifically targeting the tumor. Moreover, the association of poorly water soluble drugs
with soluble macromolecules can increase the water solubility of such hydrophobic
drugs. Finally, association of chemotherapeutic agents with macromolecules can also
increase the drugs?? circulation time by decreasing the rate of renal clearance thus leading
to improve pharmacokinetics.
A class of spherical, hyperbranched polymers known as dendrimers has received
much attention as potential vehicles for anticancer drug delivery. Dendrimers based on
melamine might afford such use as macromolecular carriers for drug delivery. Therefore
an evaluation of melamine dendrimers is reported. The goal of objective one was to
assess both the in vitro and in vivo biocompatibilities of a cationic dendrimer based on
melamine. The results reported herein indicate that this particular species of dendrimer is
not suitable for in vivo use and did not warrant further investigation.
The goals of objective two were to see what impact surface modification had on
the in vitro and in vivo toxicities of a melamine dendrimer. The results presented here
indicate that surface modification of a cationic dendrimer to anionic or neutral species
can extensively increase biocompatibility. Moreover, the introduction of neutral
poly(ethylene glycol) (PEG) grafts affords the most protection in vitro and in vivo.
Interaction with albumin, controlled drug release, cellular uptake along with
favorable biodistribution patterns are vital factors that must be evaluated when screening
a drug delivery system. Evaluating the PEGylated dendrimer as a vehicle for anticancer
drug delivery, the goal of objective three, provides initial evidence that the PEGylated
dendrimer displays favorable characteristics as a vehicle for drug delivery and justifies
additional studies utilizing in vivo models
Policing serious public disorder: the search for principles, policies and operational lessons. [In two volumes]
No full textThe paper examines the influence of central government on the police response to serious public disorder; the effectiveness or otherwise of the law and the way in which it is used by the police in their response to such disorder, and searches for sone principles which need to be followed if the police are to maintain the general support of the communities in which they are required to act. Some comparisons are made, and differences highlighted, between the police commander in his response to serious public disorder, once it has broken out, and the military commander in battle. But, guided by lessons from history, the paper principally concentrates on the environment in which the operational police commander is required to act in responding to actual or potential serious public disorder, pointing out that he is dependant for his success on firstly, an effective system of command and control; secondly, on an intelligence system which feeds relevant and accurate information on which he can make sound and informed decisions; and thirdly, the physical resources, e.g. personnel and equipment, and the approved tactics which enable him to restore public tranquility once disorder has broken out. But before he can use the physical resources effectively, he must have a sound strategy for dealing with actual or potential disorder
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[Front Matter]
No full textCover includes text:URBAN PROBLEMSPhillip J. Murphy, Taunya L. Banks, Chester McGuire, Henry W. McGee, Jr., Hugh B. Price, Michael Johnston, Doris ZelinksyUCLA EDITIONWith Special Supplements on:The Frederick Douglass Moot Court Competition andThe Minority Candidate and the Bar Examination: Symposiu
Writing from the shadowlands: how cross-cultural literature negotiates the legacy of Edward Said
No full textThis thesis examines the impact of Edward Said's influential work Orientalism and its legacy in respect of contemporary reading and writing across cultures. It also questions the legitimacy of Said's retrospective stereotyping of early examples of cross-cultural representation in literature as uncompromisingly 'orientalist'.
It is well known that the release of Edward Said's Orientalism in 1978 was responsible for the rise of a range of cultural and critical theories from multiculturalism to postcolonialism. It was a study that not only polarized critics and forced scholars to re-examine orientalist archives, but persuaded creative writers to re-think their ethnographic positions when it came to the literary representations of cultures other than their own. Without detracting from the enormous impact of Said, this thesis isolates gaps and silences in Said that need correcting. Furthermore, there is an element of intransigence, an uncompromising refusal to fine-tune what is essentially a binary discourse of the West and its other in Said's work, that encourages the continued interrogation of power relations but which, because of its very boldness, paradoxically disallows the extent to which the conflict of cultures indeed produced new, hybrid social and cultural formations.
In an attempt to challenge the severity of Said's claim that 'every European, in what he could say about the Orient, was consequently a racist, an imperialist, and almost totally ethnocentric', the thesis examines a number of different discursive contexts in which such a presumption is challenged. Thus while the second chapter discusses the 'traditional' profession-based orientalism of nineteenth-century E. G. Browne, the third considers the anti-imperialism of colonial administrator Leonard Woolf. The fourth chapter provides a reflection on the difficulties of diasporic 'orientalism' through the works of Michael Ondaatje while chapter five demonstrates the effects of the dialogism used by Amitav Ghosh as a defence against 'orientalism'. The thesis concludes with an examination of contemporary writing by Andrea Levy that appositely illustrates the legacy of Said's influence.
While the restrictive parameters of Said's work make it difficult to mount a thorough-going critique of Said, this thesis shows that, indeed, it is within the restraints of these parameters and in the very discourse that Said employs that he traps himself. This study claims that even Said is susceptible to 'orientalist' criticism in that he is as much an 'orientalist' as those at whom he directs his polemic
Victorian values and the Victorian theatre
No full textI contend that 'morality, respectability, and decorum', were Victorian values trumpeted particularly loudly in Birmingham because of the local dominance of Nonconformism. Nonconformists had materially delayed the granting of a licence to Birmingham's playhouse, and continued actively hostile to its existence. Their influence on the prevailing 'official' moral climate is apparent in the reluctance of the local magistracy to grant music hall licence applications. Theatre managers here, then, laboured under an added imperative to maintain tranquil, well-conducted houses, presenting wholesome fare, and with strong community links.
II
My contention is that the theatre embraced and, occasionally, stimulated technological innovation. I also argue that Birmingham industrialists played a crucial role in materially changing both the functioning and the appearance of playhouses and music halls.
That the revolution in mobility was the overriding factor in the contemporary mushrooming of playhouses and music halls is, I suggest, too apparent to be gainsaid. I focus closely on the transformation of Birmingham's transport links, both externally and within the town, and the readiness of local promoters and managers of theatres to exploit the new opportunities to attract audiences.
III
I suggest that if cultural imperialism operated more subtly than the political brand, imperialism it remained. The relationship with the fledgling United States displayed the classic characteristics of paternalism and condescension, not unmixed with arrogance, on . the part of the metropolitan power, and a general deference, giving way to fits of resentment, pique, and sometimes open rebellion, on the part of the erstwhile colonials. Minstrelsy and the cult of the 'Wild West' represent the beginnings of a reversal of the hitherto one-way cultural traffic, mirroring changes in the transatlantic political balance. I argue that the advent of steam navigation was a key factor in the expanding and vibrant Anglo-American exchange, with Birmingham playing a full role in that exchange
Wirt, Frederick M., and Michael W. Kirst, Curricular Decisions in the Political System, pp. 202-225 in Fredrick M.Wirt and Michael W. Kirst, The Political Web of American Schools . Boston: Little Brown and Co, 1972. Revised edition, 1975, under the title Political and Social Foundations of Education. Berkley, CA: McCutchan.
No full textRevises and extends their 1971 RER article, An Analysis of Curriculum Policy-Making. (Kirst, first author
John Frederick Knott - Bibliography from John Frederick Knott. 9 December 1938 — 5 October 2017
No full textJohn Knott was a leading expert in materials, fracture and structural integrity applied particularly to the fields of nuclear power generation and aero-engine applications. He made significant contributions to the quantitative scientific understanding of fracture processes in metals and alloys and its applications in engineering. His early work elucidated the role of microstructure in the initiation and propagation of cracks and involved detailed analysis of the micro-mechanisms of cleavage, ductile and fatigue fracture modes in many types of steel and non-ferrous alloys. He developed innovative techniques of mechanical testing which allowed detailed monitoring of crack propagation. He was the author of a much-used text book on the principles of fracture mechanics.The wide range of his expertise meant that John Knott was in high demand to serve on advisory committees for both government and industry organizations, particularly in the civil nuclear power generation and aerospace industries. With his deep knowledge of materials behaviour, he was invited to give many prestigious lectures at conferences. He was a convivial character with a keen sense of humour and often entertained conference dinners with poems he had composed about the particular event and about other participants
AN OVERVIEW OF MAJOR SOURCES OF DATA AND ANALYSES RELATING TO PHYSICAL FUNDAMENTALS IN INTERNATIONAL COMMODITY MARKETS
No full textThe debate on whether price movements in commodity markets are determined by changes in physical supply and demand fundamentals or by the speculative effects of financial investors seems to find some element of agreement on one particular point: the need for increased transparency and improved information on futures markets and physical commodity markets. This discussion paper provides an assessment of the current situation with regard to availability of information on physical commodity markets, pointing to some of the existing information gaps and areas for improvement. The paper presents a comprehensive account of the different information sources for physical commodity markets (including their websites), and could therefore be considered a practical information tool in itself, of use to different stakeholders interested in knowing about developments in these markets.
Clinical Trials for Cancer
No full textPresented by Nova Southeastern University; hosted by Fred Lippman, R.Ph., Ed.D. Chancellor Health Professions Division; with guests T.J. Sharpe, Patient, Survivor, Advocate, Author, and Michael Kasper M.D., Radiation Oncologist, Lynn Cancer Institute, Boca Regional Hospital
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