38 research outputs found
Double-blind, randomised, placebo-controlled trial on the effect of L-carnitine and L-acetylcarnitine on sperm parameters in men with idiopathic oligoasthenozoospermia
No full textCarnitine is essential for energy metabolism and spermatozoa maturation. Combining L-carnitine and L-acetylcarnitine with micronutrients has been investigated as a treatment for infertility in men. We evaluated the effects of a therapeutic formulation, Proxeed Plus, on sperm parameters in oligoasthenozoospermic men. This prospective, randomised, double-blind, placebo-controlled clinical trial involved 175 males (19-44 years) with idiopathic oligoasthenozoospermia who failed to impregnate their partners (12 months). Males received Proxeed Plus or placebo for 3 and 6 months. Sperm volume, progressive motility and vitality significantly (p < 0.001) improved after 6 months compared to baseline. Sperm DNA fragmentation index significantly decreased compared to baseline (p < 0.001) and the 3-month therapy (p = 0.014) in treated men. Increased seminal carnitine and α-glucosidase concentration also positively correlated with improved progressive motility. Decreased DNA fragmentation index was the good predictor of progressive sperm motility >10%, and simultaneous measurement of changes in sperm vitality and DNA fragmentation index gave the highest probability of sperm motility 10% (AUC = 0.924; 95% CI = 0.852-0.996; p < 0.001). Logistic regression analyses revealed DNA fragmentation index decrease as the only independent predictor of sperm motility 10% (OR = 1.106; p = 0.034). We have demonstrated the beneficial effects of carnitine derivatives on progressive motility, vitality and sperm DNA fragmentation. Combining metabolic and micronutritive factors is beneficial for male infertility
Double-blind, randomised, placebo-controlled trial on the effect of L-carnitine and L-acetylcarnitine on sperm parameters in men with idiopathic oligoasthenozoospermia
No full textCarnitine is essential for energy metabolism and spermatozoa maturation. Combining
L‐carnitine and L‐acetylcarnitine with micronutrients has been investigated as a
treatment for infertility in men. We evaluated the effects of a therapeutic formulation,
Proxeed Plus, on sperm parameters in oligoasthenozoospermic men. This prospective,
randomised, double‐blind, placebo‐controlled clinical trial involved 175
males (19–44 years) with idiopathic oligoasthenozoospermia who failed to impregnate
their partners (12 months). Males received Proxeed Plus or placebo for 3 and
6 months. Sperm volume, progressive motility and vitality significantly (p < 0.001)
improved after 6 months compared to baseline. Sperm DNA fragmentation index significantly
decreased compared to baseline (p < 0.001) and the 3‐month therapy
(p = 0.014) in treated men. Increased seminal carnitine and α‐glucosidase concentration
also positively correlated with improved progressive motility. Decreased DNA
fragmentation index was the good predictor of progressive sperm motility >10%, and
simultaneous measurement of changes in sperm vitality and DNA fragmentation
index gave the highest probability of sperm motility 10% (AUC = 0.924; 95%
CI = 0.852–0.996; p < 0.001). Logistic regression analyses revealed DNA fragmentation
index decrease as the only independent predictor of sperm motility 10%
(OR = 1.106; p = 0.034). We have demonstrated the beneficial effects of carnitine
derivatives on progressive motility, vitality and sperm DNA fragmentation. Combining
metabolic and micronutritive factors is beneficial for male infertility
In response to: “Is testis sparing surgery an acceptable option for small testicular malignant tumor with normal contralateral testicle?”
No full text
Approximation properties of a new generalized Bernstein-Kantorovich operators
No full textBy means of construction of suitable functions and the method of Bojanic-Cheng, the author gives the rate of convergence of a new generalized Bernstein-Kantorovich operators for some absolutely continuous functions
Testis sparing surgery for treatment of small testicular lesions: Is it feasible even in germ cell tumors?
No full textThe treatment of stage A testicular seminoma by carboplatin monochemotherapy
No full textBackground/Aim. Although radiotherapy is considered to be a standard treatment of stage A testicular seminoma, an increasing number of studies have reported encouraging results of the treatment by carboplatin monochemotherapy (CBDCA). The aim of this study was to analyse the treatment results of patients with clinical stage A seminoma treated by CBDCA on daily basis in the period June 1999 to September 2008. Methods. A total of 124 patients, mean age 36.63 years (20-62 years), with stage A testicular seminoma were treated, upon radical orchiectomy, by adjuvant CBDCA (400 mg/m2 on day 1 and 22). Results. Chemotherapy was well tolerated, except moderate nausea on the day of the drug administration and the following day. No patient had any serious disorders in blood cells count requiring substitutional treatment. During the mean follow-up period of 37.5 (range 6-111) months, three relapses were noted (2.41%) and none neoplasm of contralateral testicle or any other organ. Conclusion. Simple and easy carboplatin administration with excellent treatment results, along with good tolerance and absence of comorbidity, poses itself as a new 'gold standard' of treatment for stage A testicular seminoma.</jats:p
War and Cessation of Violence: Designing Just Institutions
No full textInstitutions are often rooted in violence and power, and war is one of them. At the same time, war continues to be one of the most important institutions that ensure the long-term unity of a group, albeit at the cost of confrontation with another, rival group. Therefore, an important role in cessation of violence is played by how fair new institutions are. It is the justice of post-conflict institutions that makes it possible to achieve sustainable peace. The article considers the features of social and asocial acts that strengthen or undermine relations in a group or between groups and affect the justice of institutions. Cessation of destruction and violence ends the period of forced unification of a group and opens up opportunities for finding other common purposeful activities. The content of this activity is the essence of the project, in which the most important activity in terms of fostering peace is human change. The significant problem for this is when and how war should be stopped, and whether it can be done at the desired time. During the transition from war to peace, various obstacles arise, which often do not depend on the evil or good will of the participants in peace establishment. The author comes to the conclusion that the end of war always faces the problem of fictitious construction of the main enemy, done by each party of the conflict to motivate its population. This fictitious enemy is always presented as the source and cause of the coming total extermination. To establish peace, it is necessary to debunk this fiction
On the Metamorphosis of One Institution of Civil Society
No full textThe article presents a version of the evolution of the police institution, which was originally part of civil society, not the state. A few paragraphs from Hegel’s lectures on the philosophy of law become the starting point of this reconstruction. Based on the ideas expressed in them, the author explains the mechanism of the emergence of the police from the activities of citizens to establish rules (protocols) of interaction, the supervision of which they jointly conduct for the common good-this, in fact, is the purpose of the police initially. The proposed reconstruction can be useful in two aspects. Firstly, it points to the gradual degeneration of the institution of the police, to its transformation from an institution of civil society into an element of the state sys-tem and an organ of external violence, and consequently, to a decrease in the participation of citizens in the supervision of the observance of the common good and their transformation into a passive object of alien power influence. Secondly, this reconstruction shows that various types of modern civic activity in the field of social policy (policy making) originated as part of the first police protocols and related actions. © 2022 Petar Bojanic.Health and Safety Executive, HSE; National Research University Higher School of Economics, ВШЭ; Council on grants of the President of the Russian Federation*The article was prepared in the course of the research in the framework of the Basic Research Program of the National Research University Higher School of Economics (HSE) and with the use of subsi - dies within the state support of the leading universities of the Russian Federation “5-100”
Meta-Analysis of Adipose Tissue Derived Cell-Based Therapy for the Treatment of Knee Osteoarthritis
No full textAcknowledgments: In this section, you can acknowledge any support given which is not covered by the author contribution or funding sections. This may include administrative and technical support, or donations in kind (e.g., materials used for experiments).Peer reviewe
