5,462 research outputs found
Chemical consequences of mechanical bonding in catenanes and rotaxanes: isomerism, modification, catalysis and molecular machines for synthesis
No full textResearch on mechanically interlocked molecules has advanced substantially over the last five decades. A large proportion of the published work focusses on the synthesis of these challenging targets, and the subsequent control of the relative position of the covalent sub-components, to generate novel molecular devices and machines. In this Feature Article we instead review some of the less discussed consequences of mechanical bonding for the chemical behaviour of catenanes and rotaxanes, and their application in synthesis, including striking recent examples of molecular machines which carry out complex synthetic task
Competitive formation of homocircuit [3]rotaxanes in synthetically useful yields in the bipyridine- mediated active template CuAAC reaction
No full textWe recently identified competitive formation of doubly interlocked [3]rotaxanes as the origin of the non- linear variation in yield of [2]rotaxane with macrocycle size in the bipyridine-mediated AT-CuAAC reaction. Selection of reaction conditions gave [2]rotaxanes in essentially quantitative yield in all cases and hard to access doubly threaded [3]rotaxanes in up to 50% yield in a single, four component coupling. Based on the effect of macrocycle structure on the reaction outcome we propose a detailed mechanism of [3]rotaxane formatio
Felton M. Johnston with Senator Robert M. La Follette Jr., Senator Pat Harrison, White House Press Secretary Stephen Early, and unidentified man.
No full textHandwritten signatures: Pat Harrison, [name illegible], Robert M. La Follette Jr., Stephen Earlyhttps://egrove.olemiss.edu/fmjohnston/1071/thumbnail.jp
A kinetic self-sorting approach to heterocircuit [3]rotaxanes
No full textIn this proof-of-concept study, an active-template coupling is used to demonstrate a novel kinetic self-sorting process. This process iteratively increases the yield of the target heterocircuit [3]rotaxane product at the expense of other threaded species
Self-consciousness and the image of self in the poetry of Stephen Spender, 1928 to 1934
No full textThe purpose of this thesis is twofold. First, to demonstrate the value and significance of Spender's early poetry in terms of its vision and technique. Through a series of close readings the thesis traces the ways in which Spender's early poetry not only shows itself to be self-conscious but also manipulates images of self. Presenting images of self, Spender achieves a balance between engagement with and distance from the self, and the reader shares in the process of poetic self-awareness. Secondly, to demonstrate the broader value of the poetry. Spender's poetry presents a distinctive exploration of the possibilities of self in relation to the external world. The resolution of Spender’s questioning and selection of both personal and public values, rooted in his contemporary situation and private circumstances, in his poetry takes the form less of historical document than of human record. The period on which I focus, 1928 to 1934, represents Spender’s first, and arguably most significant, poetic phase. The thesis is specifically concerned with four texts: Nine Experiments. Spender's contributions to Oxford Poetry (1929 and 1930), Twenty Poems and Poems (1933 and 1934). Nine Experiments marks the beginning of a particular approach and lyric style which finds its culmination in Poems (1933 and 1934). The earliest poetry is interesting largely insofar as it looks forward to later themes and techniques. In Nine Experiments and Oxford Poetry (1929 and 1930) we see Spender's often successful struggle to achieve effective forms in which to explore issues of self and value. Twenty Poems and Poems (1933 and 1934) concentrate on themes of love and friendship and the pressure on the poet of the contemporary political scene. The poetry does not reconcile the demands of the external, public world with his inner desires and aspirations, but presents a series of fascinatingly unresolved tensions. The thesis explores the way these poems strive for certainty. This striving stems from the tension between Spender's desire to politicize poetry and his tendency to the lyrical, personal statement
Stephen Graham Jones
No full textThis lesson explores different understandings of readings, genres, and the writing process through the use of Stephen Graham Jones' short essay, "What You Can Remember".
This resource includes materials for four class periods. Created for English Language Arts and Reading III.
Texas Essential Knowledge and Skills (TEKS)
Discuss and write about the explicit and implicit meanings of text; analyze the author's purpose, audience, and message within a text; compose informational texts such as explanatory essays, reports, resumes, and personal essays using genre characteristics and craft;This lesson explores different understandings of readings, genres, and the writing process through the use of Stephen Graham Jones' short essay, "What You Can Remember"
The Microbiome: A New Target for Research and Treatment of Schizophrenia and its Resistant Presentations? A Systematic Literature Search and Review
No full textBackground: The gastrointestinal system hosts roughly 1,800 distinct phyla and about 40,000 bacterial classes, which are known as microbiota, and which are able to influence the brain. For instance, microbiota can also influence the immune response through the activation of the immune system or through the release of mediators that are able to cross the brain blood barrier or that can interact with other substances that have free access to the brain, such as tryptophan and kynurenic acid, which is a metabolite of tryptophan and which has been involved in the pathogenesis of schizophrenia. Objectives: This paper reviews the possible relationships between microbiome, schizophrenia and treatment resistance. Given the possibility of a role of immune activation and alterations, we also describe the relationship between schizophrenia and immune inflammatory response. Finally, we report on the studies about the use of probiotic and prebiotics in schizophrenia. Methods: Cochrane library and PubMed were searched from the year 2000 to 2018 for publications about microbiome, immune-mediated pathology, schizophrenia and neurodevelopmental disorders. The following search string was used: (microbiome or immune mediated) AND (schizophrenia OR neurodevelopmental disorder). Associated publications were hand-searched from the list of references of the identified papers. A narrative review was also conducted about the use of probiotics and prebiotics in schizophrenia. Results: There exists a close relationship between the central nervous system and the gastrointestinal tract, which makes it likely that there is a relationship between schizophrenia, including its resistant forms, and microbiota. This paper provides a summary of the most important studies that we identified on the topic. Conclusions: Schizophrenia in particular, remain a challenge for researchers and practitioners and the possibility of a role of the microbiome and of immune-mediated pathology should be better explored, not only in animal models but also in clinical trials of agents that are able to alter gut microbiota and possibly influence the mechanisms of gastrointestinal inflammation. Microbiome targeted treatments have not been well-studied yet in patients with mental illness in general, and with schizophrenia in particular. Nonetheless, the field is well worth of being appropriately investigated. Copyright © 2018 Cuomo, Maina, Rosso, Beccarini Crescenzi, Bolognesi, Di Muro, Giordano, Goracci, Neal, Nitti, Pieraccini and Fagiolini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms
Outsourcing Logistics Can Help Small Businesses Compete
No full textExcerpt: Approximately 90 percent of companies that outsourced reported the relationship was either successful or somewhat successful. Author\u27s biography: Stephen M. Rutner is a professor of logistics and intermodal transportation at Georgia Southern University and director of the Ph.D. program in logistics/supply chain management. He can be contacted at [email protected]
Author Correction: Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs
No full textThe original version of this Article contained an error in the spelling of the author Steven M. Coyne, which was incorrectly given as Stephen M. Coyne. This has now been corrected in both the PDF and HTML versions of the Article.</jats:p
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