43 research outputs found
Personal Papers (MS 80-0002)
No full textLetter from Gid L. Neal to Thomas Leroy James discussing the sale of the Campbell Property
Molecular characterization of the protein-protein interaction between HTLV-1 Tax and GSK-3ß
No full text2010 Spring.Includes bibliographic references (pages 90-100).Covers not scanned.Print version deaccessioned 2022.The human T-cell leukemia virus type 1 (HTLV-1) encodes a viral oncoprotein termed Tax, which plays a major role in transforming HTLV-1- infected cells. Tax is a potent transcriptional activator that stimulates HTLV-1 viral and cellular gene transcription. In addition, Tax disrupts a number of cell signaling pathways involved in cell growth and survival. Glycogen synthase kinase-33 (GSK-33) is a ubiquitously expressed serine/threonine kinase present in all eukaryotic cells, which functions as a critical regulator of a wide range of cell signaling pathways. As GSK-33 is constitutively active in resting cells, it is primarily regulated through inhibition. Ser-9 phosphorylation is inhibitory to the kinase activity of GSK-33. Deregulation of GSK-33 has been linked to many human diseases such as Alzheimer’s disease and cancers. It has been reported in Aida Ulloa’s thesis that Tax inhibits GSK-33 kinase activity toward both primed and non-primed substrates through direct association. To delineate the protein-protein interaction between Tax and GSK-33, we compared the amino acid sequence of Tax with a well-characterized short peptide deriving from the GSK-33 interacting domain (GID) of Axin, and found that Tax contains a notable amino acid sequence homology to Axin GID. The region spanning Tax amino acids 185 - 205 has 24% sequence identity and 19% similarity with Axin GID. We named this region the putative Tax GID. We characterized the putative Tax GID biochemically, and discovered that a longer peptide (Tax aa. 138 - 205) of the putative Tax GID strongly inhibits GSK-3(3 kinase activity in vitro. Bioinformatics computation was used to predict the secondary structure of the Tax GID, which was further used in our docking test to identify a potential binding interface in GSK-3p. This was tested by GST pulldown and Co-IP assays using point and deletion mutants. In addition, the effects of Tax-GSK-3(3 interaction on the downstream (3-catenin and NFAT pathways were characterized by luciferase reporter assays. However, unexpectedly, we observed that Tax expression has little effects on p-catenin and NFAT transcriptional activation
Definition, investigation and management of gastrointestinal dystonia in children and young people with neurodisability
No full text\ua9 Author(s) (or their employer(s)) 2025. No commercial re-use. See rights and permissions. Published by BMJ Group. Background: Children and young people with severe neurodisabling conditions (CYPSND) experience severe functional gastrointestinal symptoms and dependence on artificial nutrition. \u27Gastrointestinal dystonia\u27 (GID) has been applied by clinicians when symptoms become debilitating and potentially life-limiting. Evidence is lacking regarding the definition and appropriate management of GID. Methods: We therefore assembled a RAND appropriateness panel. We performed a systematic review, created an online survey and distributed this to a panel of 27 experts from five stakeholder groups from 13 UK specialist centres across the British Isles (gastroenterology, neurology/neurodisability, surgery, palliative care and allied health professionals). A Disagreement Index ≥1 indicated disagreement. Findings: The panel rated the appropriateness of 250 statements covering the following in GID: definition, clinical evaluation, nutritional assessment/feeding strategies, investigations, medications and prescribing, surgical interventions, safeguarding, palliative care and ethics. Agreement was reached except in selected statements regarding uncommon diagnostic features. There was uncertainty in specific clinical scenarios regarding: investigation, the use of blenderised diet, certain pharmacological agents and surgical interventions. The only intervention deemed inappropriate was antireflux surgery in the context of GID and gastrointestinal dysmotility without reflux disease. The remaining statements (198) were considered appropriate. Interpretation: We present a comprehensive review, agreement on the definition of GID and recommendations on management pathways agreed by a selected panel of multidisciplinary experts. Clear diagnostic criteria will enable important epidemiological work to record outcomes for this complex patient group. Identifying the associated morbidity, burden of care and mortality will help advocate for appropriate health resources and support to carers and families
Seed dispersal, herbivory and recruitment failure of Persoonia elliptica (Proteaceae) in Western Australian Jarrah (Eucalyptus marginata) forest
No full textPersoonia elliptica is a resprouting understorey tree species of the jarrah (Eucalyptus marginata) forests of South-Western Australia. All known populations are lacking in seedlings and saplings, resulting in population structures made up solely of mature trees and exhibiting clear recruitment failure. Little research has been done on this species other than a single study by Abbott and Van Heurck (1988) which described population structures and speculated that increased kangaroo herbivory might be the cause of recruitment failure. This study addresses the issue of recruitment failure, in particular with regards to seed production, viability and dispersal, and herbivory. This work describes the ecology of the species including fruit production, seed viability and population structure. The relationship between P. elliptica and the fauna of the region is examined with regard to seed dispersal vectors and dispersal distances, while the role macropods play in seedling and new growth herbivory and the link with recruitment failure is also examined.
Two study sites were investigated over a period of eight months in the northern jarrah forest region, at Avon Valley National Park and in state forest near Sawyers Valley. Species ecology was examined using fruit counts, tree size measurements and soil seed bank estimation, while seed dispersal and herbivory were examined using seed removal ‘cafeteria’ experiments and infrared motion sensing cameras to detect and record faunal activity.
Fruit production is low in P. elliptica with only 9% of flowers becoming mature fruits. Seed viability is high in new season seeds, but seeds collected from the soil seed bank (assumed aged one year or older) were not viable. Five fauna species act as dispersal vectors of P. elliptica seed; Macropus fuliginosus, Macropus Irma, Strepera versicolour, Mus musculus and Oryctolagus cuniculus. Of these the currawong (S. versicolour) has not previously been observed interacting with P. elliptica seeds. Macropods exhibited a strong browsing preference for P. elliptica when presented with fresh foliage, and are also therefore, likely to consume seedlings. The wallaby, M. Irma, browsed foliage to a height of 0.5 metres while the kangaroo, M. fuliginosus, browsed foliage up to one metre. This level of browsing pressure is a potential cause of recruitment failure.
The key findings of the study highlight that recruitment failure within populations of P. elliptica is likely to be caused by a number of factors potentially relating to the species ecology and relationships with fauna, particularly herbivores. This raises questions on the potential for this species to persist into the future within the jarrah forest and provides vital information concerning possible management approaches to encourage recruitment
The evolutionary rewiring of ubiquitination targets has reprogrammed the regulation of carbon assimilation in the pathogenic yeast Candida albicans
No full textDate of Acceptance: 13/11/2012 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited. Correction for Sandai et al., The Evolutionary Rewiring of Ubiquitination Targets Has Reprogrammed the Regulation of Carbon Assimilation in the Pathogenic Yeast Candida albicans published 20-01-2015 DOI: 10.1128/mBio.02489-14Peer reviewe
Jatropha curcas biodiesel production in Kenya: economics and potential value chain development for smallholder farmers.
No full textCurriculum renewal in translator training: vocational challenges in academic environments with reference to needs and situation analysis and skills transferability from the contemporary experience of Polish translator training culture
No full textThis work examines the principles underlying curriculum renewal for the training of translators. It considers recent work from Translation Studies on the nature of translation competence, arguing that a more dynamic understanding of the nature of translation must be reflected in a departure from traditional transmissionist pedagogical practices. Consideration of these issues in a curricular framework must also acknowledge the ideological potential of curricula themselves to prioritise certain relationships between the learner and society, relationships which are investigated from the perspective of a socially situated view of the translator. With regard to determining curricular orientation, a methodology of needs and situation analysis is suggested as a means of profiling essential characteristics of the translator’s work in specific contexts, informed by such issues as changing notions of translation, changing employment norms in the language services sector, locally prevailing norms in the educational environment, etc. Major issues impacting on the situational consideration of needs in translator training are examined, in particular the way in which the vocational / academic dichotomy may problematise training in academic environments. The notion of skills transferability is presented as a theme which is important both to the training of translators and to maximising social reconstructionist potentials in university curricula. In the final chapter, the issues presented in the first three chapters are discussed in relation to the challenges facing translator training in Polish universities with the implementation of Bologna Process reforms. In particular, Polish notions of academic and vocational education are analysed and the experience of one particular university philology is presented as a case study. The conclusion takes the themes discussed in the work and presents them in terms of the opposition between ‘training translators’ and ‘teaching translation.’ Future research trajectories are also proposed
'Operation Enduring Nightmare'? : a strategic critique of the military intervention in Afghanistan from October 2001-October 2008
No full textIncludes abstract.Includes bibliographical references.In October 2011, the war in Afghanistan reached its ignominious ten year anniversary. As the conflict rolls on relentlessly, observers from across all disciplines, and indeed the general public themselves, have attempted to identify why the intervention, which began as Operation Enduring Freedom, has instead become an ‘Enduring Nightmare’. This dissertation attempts to provide empirical reasoning to this question by means of a literature review of the established strategic critiques of the intervention between the years of October 2001 and October 2008
Shams al-dim al-Sakhawi as a historian of the 9th/15th century : with an edition of that section of his chronicles (Wajiz al-kalam) covering the period 800-849 / 1397-1445
No full textAlthough a prolific writer of history, Sakhawi is, primarily, a
traditionist. As such, accuracy both in utterance and writing would,
by the very nature of his training, be his first objective.
Modern writers appear to have neglected the importance of his
contribution to the understanding of the history of his century.
accept for a few articles, comparatively little has been written. It
is, therefore, strange that such a mine of information as Sakhawi's
writing presents has remained so long in oblivion.
In this thesis an attempt has been made to evaluate that contribution
together with an edition of part of his work.
The study has been divided into three sections, the first dealing
with Sakhawi’s life and times. This part of the study is based largely
on his autobiography which was written but a few months before he died.
During research no reference was discovered to this most informative
work.
The section falls into three chapters, the first of which endeavours
to show the political and educational aspects of Cairo during the early
part of Sakhawi's lifetime. Cairo was his native city and, as such,
made great impact on his early life.
In the second chapter the position of his family, his Shaykhs, the
academic journeys he made, his residence in Hijaz and the last phase of
his life are portrayed.
The third chapter deals with his activities as an adult, his reputation
as a traditionist together with a survey of his works as presented in
his autobiography.
In the second part, the study deals exclusively with Sakhawi as
a historian of the 9th/15th century. This part also is divided into
two chapters, the first of which considers the following aspects: -
I Sakawi's works on the century;
II His motives, methods and literary style and
III His treatment of the history of the century.
The second chapter collates Sakhawi's methods of selecting his
information and the painstaking efforts he made to verify them, together
with his historical achievements, while the last two topics endeavour to
evaluate his task as a historian in that century.
Section three presents the hitherto unedited part of Wajiz al-Kalam...
which deals with the history of the 9th/15th century. This section
also falls into the three divisions of preface, text and annotations.
The last divides again into two groups one of which deals with the
textual variants mentioned in the footnotes and the other attempts to
deal with the interpretation of most of the idiom, colloquial expressions
and the names of places and personalities mentioned in the supplement to
the text
Making Sense of the Census: Classifying and Counting Ethnicity in Oceania, 1965-2011
No full textAs the flagship government effort to count and classify its population, censuses are a key site for rendering and making visible group boundaries. Despite claims to objective rationality, however, census taking is a political and inherently subjective exercise. Censuses help shape the very categories they claim to capture: censuses do more than reflect social reality, they also participate in the social construction of this reality (Kertzer and Arel, 2002b, p. 2). While ethnicity – as a social construct – is imagined, its effects are far from imaginary, and census categorisations may have significant material consequences for the lives of citizens.
Although an increasing number of studies have examined how and why governments in particular times or places count their populations by ethnicity, studies that are both cross-national and longitudinal are rare. Attempting to in part bridge this gap, this thesis studies census questionnaires from 1965 to 2011 for 24 countries in Oceania. In doing so, it explores three general questions: 1) how ethnicity is conceptualised and categorised in Oceanic censuses over time; 2) the relationship between ethnic counting in territories to that of their metropoles; and 3) Oceanic approaches towards multiple ethnic identities. Spread over an area of thirty million square kilometres of the Pacific Ocean, Oceania provides an interesting context to study ethnic counting. The countries and territories which make up the region present an enormous diversity in physical geography and culture, languages and social organization, size and resource endowment. As the last region in the world to decolonise, Oceania includes a mix of dependencies and sovereign states.
The study finds that engagement with ethnic classification and counting is near-ubiquitous across the time period, with most countries having done so in all five cross-sectional census rounds. In general terms, in ethnic census questions ‘racial’ terminology of race and ancestry has been displaced over the focal period by ‘ethnic’ terminology of ethnicity and ethnic origin. Overall, the concept of ethnic origins predominates, although interestingly it is paired with race in the US territories, reflecting the ongoing social and political salience of race in the metropole. With respect to ethnic categories provided on census forms (and thus imbued with the legitimacy of explicit state recognition) the study finds a shift away from the imagined and flawed Melanesian/Micronesian/ Polynesian racial typology and other colonial impositions to more localised and self-identified Pacific identities. It is theorised that these shifts are emblematic of broader global changes in the impetuses for ethnic counting, from colonially-influenced ‘top down’ counting serving exclusionary ends to more inclusive, ‘bottom up’ approaches motivated by concerns for minority rights and inclusive policy-making
