16,769 research outputs found
Neal Lane Farewell Letters to PCAST Members
No full textA collection of letters from Neal Lane to various members and contributors of the President's Committee of Advisors on Science and Technology (PCAST), thanking them for their service to PCAST during President Clinton's administration. Recipients include Norman Augustine, Francisco J. Ayala, John M. Deutch, Murry Gell-Mann, David A. Hamburg, John Holdren, Diana MacArthur, Shirley M. Malcom, Mario J. Molina, Peter Raven, Sally Ride, Judith Rodin, Charles A. Sanders, David E. Shaw, Charles M. Vest, Virginia V. Weldon, Lilian Shiao-Yen Wu, and John A. Young
The Routledge Handbook of Literary Geographies
No full textThe Routledge Handbook of Literary Geographies provides a comprehensive overview of recent research and a range of innovative ways of thinking literature and geography together. It maps the history of literary geography and identifies key developments and debates in the field. Written by leading and emerging scholars from around the world, the 38 chapters are organised into six themed sections, which consider: differing critical methodologies; keywords and concepts; literary geography in the light of literary history; a variety of places, spaces, and landforms; the significance of literary forms and genres; and the role of literary geographies beyond the academy. Presenting the work of scholars from different disciplinary backgrounds, each section offers readers new angles from which to view the convergence of literary creativity and geographical thought. Collectively, the contributors also address some of the major issues of our time including the climate emergency, movement and migration, and the politics of place. Literary geography is a dynamic interdisciplinary field dedicated to exploring the complex relationships between geography and literature. This cutting-edge collection will be an essential resource for undergraduate and postgraduate students in both Geography and Literary Studies, and scholars interested in the evolving interface between the two disciplines
Evolution of cooperation among tumor cells
No full textThe evolution of cooperation has a well established theoretical framework based on game theory. This approach has made valuable contributions to a wide variety of disciplines, including political science, economics, and evolutionary biology. Existing cancer theory suggests that individual clones of cancer cells evolve independently from one another, acquiring all of the genetic traits or hallmarks necessary to form a malignant tumor. It is also now recognized that tumors are heterotypic, with cancer cells interacting with normal stromal cells within the issue microenvironment, including endothelial, stromal, and nerve cells. This tumor cell???stromal cell interaction in itself is a form of commensalism, because it has been demonstrated that these nonmalignant cells support and even enable tumor growth. Here, we add to this theory by regarding tumor cells as game players whose interactions help to determine their Darwinian fitness. We marshal evidence that tumor cells overcome certain host defenses by means of diffusible products. Our original contribution is to raise the possibility that two nearby cells can protect each other from a set of host defenses that neither could survive alone. Cooperation can evolve as byproduct mutualism among genetically diverse tumor cells. Our hypothesis supplements, but does not supplant, the traditional view of carcinogenesis in which one clonal population of cells develops all of the necessary genetic traits independently to form a tumor. Cooperation through the sharing of diffusible products raises new questions about tumorigenesis and has implications for understanding observed phenomena, designing new experiments, and developing new therapeutic approaches.Author manuscript. Published in final edited form as: Proc Natl Acad Sci U S A. 2006 September 5; 103(36): 13474-13479.The final published version of this article is located at: www.pnas.org/cgi/doi/10.1073/pnas.0606053103NIH U56 CA113004; to David E. AxelrodR.A. was supported by National Science Foundation (NSF) Grant SES-0240852. D.E.A. was supported by NSF Grant IIS-0312953, National Institutes of Health (NIH) Grant U56 CA113004, and New Jersey Commission on Cancer Research Grant 1076-CCR-SO. K.J.P. is an American Cancer Society Clinical Research Professor and is supported by NIH Grants CA69568, CA102872, and CA093900.NIH CA69568; to Kenneth J. PientaNIH CA102872; to Kenneth J. PientaNIH CA093900; to Kenneth J. PientaNSF SES-0240852; to Robert AxelrodNJ Commission on Cancer Research 1076-CCR-SO; to David E. AxelrodAlso available in PubMed Central. PMCID: PMC155738
Colon_Crypt_Model_041321.nlogo
No full textTitle: Colon_Crypt_Model_041321.nlogo
Research genre: Computer program
Creator: Axelrod, David E.
Date Created: 2021
Extent: 1 digital file (393 KB)
Intended Audience: Science
Description: Computer program that simulates and plots the dynamics of stem cells, transient amplifying cells, differentiated cells, and mutant cells in normal human colon crypts and early colon cancer. It has been calibrated with measurements of human biopsy specimens. Includes graphical user interface, detailed information text, and annotated code. Experiments can be run from the GUI without knowledge of coding, or from the Behavior Space Tool using example code or modified code. It has been used to simulate human colon cancer initiation, therapy, and prevention. Different chemotherapy or prevention intermittent dose schedules can be input. Chemotherapy of heterogeneous and drug resistant early colon cancers can be simulated. Circadian cell proliferation can be selected to investigate chronomodulated chemotherapy dose schedules. Simulated output can be saved in spreadsheet format, or as images of plots of cell numbers as function of time.
The model was developed in the application NetLogo version 5.3.1, and revisions made to also run in NetLogo version 6.2.0. The model will not run on the Web version of NetLogo. NetLogo is a multi-agent programmable modeling environment. It is authored by Uri Wilenski and developed at The Center for Connected Learning (CCL) and Computer-Based Modeling. It is multi-platform (Mac, Windows, or Linux) open source application.
NetLogo version 6.2.0, can be downloaded at http://ccl.northwestern.edu/netlogo/download.shtml. To download the computer program click on the red link “NLOGO" to the left.
Earlier versions of the model and its use have been described in the following publications: Theoret Biol Med Model. 2013;10:66-89. Cancer Chemother Pharmcol 2017;79:889-898. Converg Sci Phys Oncol 2017;3:035004. Cancer Inform 2019;18:1-8. JCO Clin Cancer Inform 2020;4:514-520. A forthcoming publication will describe results of circadian-timed chemotherapy.
Research Domain: Science
Subjects: Chronotherapy: Circadian: Colorectal cancer: Chemotherapy: Agent-based model
Rights statement: The author owns the copyright to this work
Cardiovascular risk after liver transplantation
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
Disputatio philosophica de dependentia creaturae a Deo in esse, fieri, et operari
No full textquam auspice Deo , sub praesidio Dn. Ioh. Rod. Ottii ... amico examini subiicit David Holzhalbius author & respondens ...Diss. Hohe Schule Zürich, 169
Structural Controls of the Neal Hot Springs Geothermal System, Eastern Oregon
No full textDetailed geologic mapping (1:24,000 scale), structural and geochemical analyses, and integration of available geophysical and well-field data were utilized to assess the structural controls of the Neal Hot Springs geothermal field in eastern Oregon. The geothermal field lies within the intersection of two regional grabens, the middle-late Miocene, north-trending, Oregon-Idaho graben and younger late Miocene to Holocene, northwest-trending, western Snake River Plain graben. It is marked by Neal Hot Springs, which effuse from opaline sinter mounds just north of Bully Creek. Production and injection wells, with temperatures up to 142°C, intersect the Neal fault zone at depths of 680-1900 m and subsidiary faults within a relay ramp or step-over within the fault zone.The stratigraphy at Neal correlates with four regional packages. Basement rocks, discovered in one well, are granite, tentatively correlated with Jurassic Olds Ferry-Izee terrane. Nonconformably above is a thick package of middle Miocene Columbia River Basalt Group lavas, regionally known as the basalt of Malheur Gorge. Conformably above are middle to late Miocene Oregon-Idaho graben lavas, volcaniclastics, fluvial and lacustrine rocks. Overlying are the youngest rocks at Neal, which are late Miocene to Pliocene, western Snake River Plain lacustrine, fluvial, and volcaniclastic rocks. The structural framework at Neal is characterized by northerly to northwest-striking normal faults, including the geothermally related Neal fault zone. Stress inversion of kinematic data reveal an extensional stress regime, including an interpreted younger, southwest-trending (~243°), least principal stress and an older, west-trending (~265°) least principal stress. The geothermal field is bounded on the east by the Neal fault, a major, west-dipping, north-northwest-striking, steeply dipping normal to oblique-slip fault, along which geothermal fluids ascend, and on the west by the concealed north-northwest-striking, west-dipping Sugarloaf Butte fault. The Neal fault zone can be modeled into two structural settings: an interpreted older, left-stepping, normal-slip fault zone and a younger, oblique sinistral-normal zone, suggested by the earlier west-trending and later southwest-trending extensional stress regimes. Recent sinistral-normal displacement may have generated a small pull-apart basin in the Neal area and facilitated development of the geothermal system. 'Hard-linkage' between the Neal and Sugarloaf Butte faults occurs through concealed, west-northwest-striking faults, including the Cottonwood Creek subvertical fault, along which lateral fluid-flow is likely. An inferred north-plunging fault intersection at the Neal Hot Springs likely controls the location of the hot springs and sinter terraces.Young structural features are evident at Neal. The Neal fault zone cuts Quaternary fans and late Miocene lower and upper Bully Creek Formation sedimentary rocks. In addition, the geothermal field is 4 km west of the active, north- to northwest-striking, normal-slip Cottonwood Mountain fault. Furthermore, the field is within several kilometers of recently detected seismicity. This, coupled with its active hot springs (~90°C), opaline sinter mounds, and geothermal fluid flow, suggest that the geothermal field lies within an active (Quaternary), southward-terminating, left-stepping fault zone, which locally acts as a pull-apart basin with sinistral- and normal-slip components
E-book : Industrial Transformation In The Developing World (author: Michael T. Rock & David P. Angel)
No full textArsip Kuliah Online 2010: E-book : Industrial Transformation In The Developing World (author: Michael T. Rock & David P. Angel
E-book : "industrial Transformations In The Developing World (author: Michael T. Rock & David. P Angel)
No full textArsip Kuliah Online 2010: E-book : "industrial Transformations In The Developing World (author: Michael T. Rock & David. P Angel
Landsat MSS classification of fire fuel types in Wood Buffalo National Park, northern Canada
No full textJ1: Global Ecology & Biogeography Letters; M3: Article; Milne, David Franklin, Steven E. Wilson, Bradley A. Ghitter, Geoff Heathcott, Mark McCaffrey, Thomas M. Ow, Charlotte F. Y.; Source Information: Mar1994, Vol. 4 Issue 2, p33; Subject Term: FOREST fires; Author-Supplied Keyword: Canada (Wood Buffalo National Park); Author-Supplied Keyword: Forest fire; Author-Supplied Keyword: Fuel type classification; Author-Supplied Keyword: Landsat data; Number of Pages: 0p; Document Type: Articl
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