2 research outputs found
Fabrication of Direct Compressible Tablets Containing Chatuphalathika Extract Obtained through Microwave-Assisted Extraction: An Optimization Approach
No full textThis research sought to optimize the microwave-assisted extraction of Chatuphalathika as an herbal recipe maximizing the active compounds and the antioxidant activity by the Box–Behnken design. Three factors—microwave power, time, and cycle—were varied. Eight responses—extraction yield, total phenolic content, gallic acid content, corilagin content, chebulagic acid, chebulinic acid, IC50 from DPPH assay, and IC50 from FRAP assay—were monitored. Furthermore, cytotoxicity was evaluated to ensure the safety of the extract. After that, the optimized extract was compressed into tablets. The results showed that the optimal condition of the microwave-assisted extraction gave the simultaneous maximum extraction yield, total phenolic content, and antioxidant activity with a microwave power of 450 W for 30 s and 3 cycles. The extract obtained from the optimal condition exhibited a good safety profile although a concentration of 5 mg/mL was used. The optimized tablets were achieved when a compression force of 1500 psi and magnesium stearate of 1% were applied, and no sodium starch glycolate was added. In conclusion, the optimal green extraction method could be used for the extraction of the Chatuphalathika. Furthermore, the fabrication of Chatuphalathika tablets was successful, as the tablets had low friability with a short disintegration time
Optimization of Semha-Pinas Extract Orodispersible Tablets Using Response Surface Methodology
Get PDFThe original dosage form of the Semha-Pinas herbal formula, an expectorant in Thai traditional medicine, is in a pill form. However, it is inconvenient to use because it must be powdered and dissolved in hot water or juice of Citrus x aurantium L. before use. The development of a new dosage form presents a challenging prospect. This work aimed to develop Semha-Pinas extract orodispersible tablets based on the response surface methodology using the Box-Behnken design. Firstly, Semha-Pinas extract was tested for its safety in HepG2 cells. The safe extract was further developed as orodispersible tablets. Four levels of three factors — compressional force (500–2,000 psi), the quantity of microcrystalline cellulose (0–15%), and the quantity of croscarmellose sodium and sodium starch glycolate (0:8–6:2%) — were screened using the one factor at a time technique. The Box-Behnken design has three levels for each factor: 1,000–2,000 psi, 5–15%, and 2:6–6:2%, respectively. Tablet thickness, hardness, friability, and disintegration time were the four responses that were monitored. The results indicated the safety of the Semha-Pinas extract, even at a concentration of 5 mg/mL. The optimal orodispersible tablet formulation had a compressional force of 1,500 psi, microcrystalline cellulose of 10%, and croscarmellose sodium to sodium starch glycolate of 4:4%. In summary, this study successfully fabricated Semha-Pinas extract orodispersible tablets using response surface methodology, achieving the desired property of fast disintegration. Moreover, these findings can serve as a valuable reference for pilot scale and industrial scale production
