2,422 research outputs found
Giovanni Pascoli, Poemi Conviviali, a cura di Giuseppe Nava
No full textIl contributo recensisce la nuova edizione dei Poemi Conviviali di Giovanni Pascoli commentati da Giuseppe Nava
"The love that made hell, paradise." Ouida re-writing the Paolo and Francesca theme in Held in Bondage
No full textThe bestselling Victorian author Ouida reveals in her novels, and, in particular, Held in Bondage, an extraordinary knowledge od Dante, by using characters and themes from the Commedia. The Paolo and Francesca theme actually constitutes part of the plot of the novel and is to be found in many of her other works, short stories and non-fiction writing
Neurally adjusted ventilatory assist : from animal studies to clinical practice
No full textPatients in the Intensive Care Unit (ICU) undergoing ventilator treatment may experience asynchrony with the ventilator, which has been associated with increased need of sedation, sleep disruption, prolonged mechanical ventilation and unsuccessful weaning from the ventilator. The search for new strategies to improve patient-ventilator interaction is ongoing. Neurally Adjusted Ventilatory Assist (NAVA) is a recently developed ventilator support that uses the Electrical Activity of the diaphragm (EAdi) as an input signal to control the ventilator. Each breath is delivered in proportion to the EAdi amplitude and follows the timing of the EAdi start and ending. NAVA may potentially improve patient-ventilator synchrony, which could be beneficial, especially in paediatric ICU patients. Further, NAVA use could be of interest during surgery and general anaesthesia, potentially reducing risk for intraoperative atelectasis formation and postoperative complications. However, the feasibility of NAVA during general anaesthesia has not been investigated. There is some uncertainty among clinicians on how to set NAVA bedside. A pragmatic strategy, targeting NAVA to different levels of muscle unloading has not been studied, but could be a means of standardizing the approach to unload. Finally, it is not known if lower unloading could improve the distribution of ventilation in favour of the dorsal regions of the lungs. Patient-ventilator synchrony and diaphragm unloading with NAVA compared to Pressure Support (PS) were evaluated in Acute Lung Injured (ALI) rabbits with increasing level of assist and in rats breathing with an added dead space in the respiratory circuit. The feasibility and efficacy of NAVA was investigated in small species, close in weight to the smallest viable human being. The pattern of breathing in NAVA and PS was studied in small species, when dead space was added. The feasibility of NAVA in sedation and anaesthesia with sevoflurane and propofol and the impact of these drugs on the pattern of breathing and muscle contractility were investigated in a big animal model. The possibility to target NAVA to different levels of respiratory muscle unloading was evaluated in Neurosurgical Intensive Care (NICU) patients and the effect of moderate unloading on the distribution of ventilation was investigated with Electrical Impedance Tomography. Synchrony with NAVA was maintained and diaphragm unloading increased when raising the assist level, while for high PS the synchrony and unloading worsened, due to wasted inspiratory efforts causing a larger work of breathing. With NAVA, oxygenation and ventilation remained in the physiologic range in small species and when dead space was added, similar PaCO2 was achieved with a lower increase in respiratory rate and minute ventilation, compared to PS. Sedation and anaesthesia with sevoflurane and propofol, during NAVA in pigs, preserved the EAdi signal and spontaneous breathing, keeping the gas exchange in the physiologic range. The tidal volume variability in NAVA was preserved both with sevoflurane and propofol, being higher in propofol, due to more frequent sighs, followed by post-sigh apnoea. With sevoflurane Neuro-mechanical and Neuro-Ventilatory Efficiency (NVE) were higher, suggesting that sevoflurane could better preserve muscle contractility, compared to propofol. In NAVA it was feasible to set the assist at different levels of respiratory muscle unloading in NICU patients, by means of the NVE. Lower muscle unloading was shown to redistribute ventilation towards the dorsal regions of the lungs. In conclusion this thesis demonstrates that NAVA improves patient-ventilator synchrony for increased assist levels and unloads the respiratory muscles with lower pressures and volumes compared to PS. NAVA is feasible and efficacious in small species, close in weight to the lowest viable human being and appears to be more efficient than PS in eliminating the CO2. NAVA is feasible during sedation and anaesthesia with sevoflurane and propofol in pigs and preserves the natural variability in pattern of breathing. Propofol in combination with NAVA is associated with more sighs and post-sigh apnoea than sevoflurane. Sevoflurane appears to preserve muscle contractility in NAVA better than propofol. NAVA can be targeted to different levels of muscle unloading by means of the NVE and lower unloading redistributes ventilation towards the dorsal regions of the lungs, providing the premise for a better matching of ventilation and perfusion.List of scientific papersI. Improved Sinchrony and Respiratory Unloading by Neurally Adjusted Ventilatory Assist (NAVA) in Lung-Injured Rabbits. Jennifer Beck, Francesca Campoccia, Jean-Christophe Allo, Lukas Brander, Fabrice Brunet, Arthur S. Slutsky, Christer Sinderby. Pediatric Research 2007; 61(3):289-294 https://doi.org/10.1203/01.pdr.0000257324.22406.93 II. Neurally Adjusted Ventilatory Assist and Pressure Support Ventilation in Small Species and the Impact of Instrumental Dead Space. Francesca Campoccia Jalde, Abdul Raoof Almadhoob, Jennifer Beck, Arthur S. Slutsky, Michael S. Dunn, Christer Sinderby Neonatology 2010; 97(3):279-285 https://doi.org/10.1159/000255167 III. Neurally Adjusted Ventilatory Assist Feasibility during Anaesthesia. A randomised crossover study of two anaesthetics in a large animal model. Francesca Campoccia Jalde, Fredrik Jalde, Peter V. Sackey, Peter J. Radell, Staffan Eksborg, Mats K.E.B. Wallin European Journal of Anaesthesiology 2016; 33(4):283-291 https://doi.org/10.1097/EJA.0000000000000399 IV. Target Unloading of Respiratory Muscles during Neurally Adjusted Ventilatory Assist. A pilot study in ICU patients. Francesca Campoccia Jalde, Fredrik Jalde, Mats K. E. B. Wallin, Fernando Suarez-Sipmann, Peter J. Radell, David Nelson, Staffan Eksborg, Peter V. Sackey. [Manuscript]</p
HERStory Makers 2023: Francesca Fotheringham
No full textFrancesca Fotheringham is a postdoctoral research associate at the University of Edinburgh studying educational psychology with a focus on neurodiversity. She took part in HERStory Makers 2023.What is HERStory Makers?HERStory Makers is a social media competition for female-identifying early career researchers to share their research, their career journeys, and to inspire the next generation. Winners are selected by public vote. HERStory Makers is also part of EXPLORATHON, Scotland's contribution to European Researchers' Night.In 2022-23, EXPLORATHON Francescasupported by the Engineering & Physical Sciences Research Council [grant number EP/X020762/1].Author contributions to contentFrancesca conceived, planned, and recorded the video content. Kirsty Ross edited the video content to insert HERStory Maker credits, added subtitles, and reduce video length to below Twitter/X limit of 2 mins and 20 secs.</p
Medicina illuminata. La Biblioteca Lancisiana di Roma
No full textL'articolo presenta i codici miniati della Biblioteca Lancisiana di Roma. La prima parte, del coautore, è dedicata alla Biblioteca. La seconda parte, di F. Manzari, tratta dei manoscritti miniati, costituiti da due codici con le opere di Avicenna e dal Liber fraternitatis della Confraternita dell'Ospedale di Santo Spirito in Sassia a Roma.The article introduces the illuminated manuscripts of the Biblioteca Lancisiana in Rome. The first part of the article, by the co-author, is dedicated to the Library. The second part, by Francesca Manzari, illustrates the manuscipts; these are two manuscripts with the works of Avicenna and the Liber fraternitatis of the Confraternity of the Hospital of Santo Spirito in Sassia in Rome
Diet and health in central‐southern Italy during the Roman imperial time
No full textThe reconstruction of ancient diets by means of stable isotopes analysis acquires a deeper meaning when their results are compared with other odonto‐skeletal indicators which are strongly contextualized in the light of historical and archaeological evidence. Nevertheless, the outcomes can be contradictory or, more realistically, they may not completely satisfy our hypotheses on how complex and diverse conditions ‐ such as health status, life style, diet and nutrition ‐ can actually interrelate in the life course of an individual. In this study we present and discuss evidences from Isola Sacra and Velia, two Roman Imperial Age coastal towns. The δ15N and δ13C values are compared with demographic and health status parameters, such as age, sex, stature, auricular exostoses, DISH, cribra orbitalia, enamel defects
Inappropriate use of neurally adjusted ventilator assist
No full textNeurally adjusted ventilator assist (NAVA) is a ventilator mode based on providing assistance to the patient in proportion to the electrical activity of the diaphragm. NAVA may improve patient-ventilator interactions. We describe a very complex case of a child with a permanent ventricular assist device where we attempted to use NAVA during the weaning process and then realised that it was impossible to use
A DH-Leavened Musicological Toolbox
No full textGraduate-level training in music research methodologies tends to ignore digital humanities work and overlook the use of digital tools created in support of new forms of reading. Training instead focuses on source material in the student’s area of interest. This material includes secondary and primary (archival) resources, as well as information resources, such as: monuments of music and critical editions; indexes; bibliographies and thematic catalogs; dictionaries and encyclopedias; digital libraries of scores or editions; and databases of period-specific newspapers or journals. Graduate students taking research methods courses already have a toolbox built from their experiences as musicians and students of music, including the ability to read and interpret music notation, to understand theoretical and analytical concepts in music, as well as a command of music history, including the canon of musical works.
Digital humanities has become a major area of academic endeavor at the “interface of technological development, epistemological change and methodological concerns." An important characteristic of digital humanities research has been its interdisciplinarity. We argue that graduate training in musicology needs to include coverage of methodologies applied by digital humanists in support of new forms of reading, not only to broaden the canon of research topics in musicology, but also to build common ground with researchers of other disciplines. We propose that librarians are well positioned to provide this expertise and training
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