323,071 research outputs found
Evaluación del desempeño del personal para determinar el nivel de competencia en la “Empresa Metal Mecánica L&S Nassi” de la ciudad de Trujillo - 2013
No full textLa presente investigación “EVALUACIÓN DEL DESEMPEÑO DEL PERSONAL PARA DETERMINAR EL NIVEL DE COMPETENCIA EN LA EMPRESA METAL MECÁNICA L&S NASSI, DE LA CIUDAD DE TRUJILLO - 2013”, permite conocer el nivel de competencias de los trabajadores del área de producción de la empresa L&S NASSI. Han participado de la presente investigación 11 colaboradores del área de producción de la empresa metal mecánica L&S NASSI, a quienes se les aplicó el formato de evaluación del desempeño desarrollado por la Dra. Martha Alles (2011), adaptado a la realidad de la empresa por los investigadores estableciendo los siguientes indicadores de competencias en dos dimensiones: Credibilidad Técnica, Productividad, Iniciativa- Autonomía y Tolerancia a la Presión (Dimensión: Calidad Profesional) y Colaboración responsabilidad, Trabajo en Equipo y Aprendizaje Continuo (Dimensión: Actitud frente al trabajo). Los resultados de la investigación nos han permitido determinar que, según la prueba estadística t-student, el nivel de competencia alcanzado por los colaboradores del área de producción no es el esperado, existiendo una brecha o GAP entre el nivel de competencia alcanzado por el colaborador y el nivel de competencia exigido por la empresa.This research “PERFORMANCE ASSESSMENT TO DETERMINATE THE
LEVEL OF COMPETENCY OF THE WORKERS IN THE L&S NASSI METAL
MECHANIC COMPANY, TRUJILLO CITY – 2013”, is made to determinate the
level of competency of the workers, in the production area of the company.
For that purpose, eleven workers of the production area participated; they were
evaluated by the format of Performance Assessment developed by Dra. Martha
Alles (2011), adapted to the reality of the company by the researches, setting the
following indicators of competency in two dimensions: technical credibility,
productivity, Initiative- Autonomy and Tolerance to the Pressure (Dimension:
Professional Quality) and Collaboration, responsibility, Team Work and
Continuing Learning (Dimension: Attitude towards work).
The results of the investigation, allowed us, according to the t-student statistic
formula, determinate that, the level of competency achieved by the workers of the
production area, are not the required, where there is a gap between the level of
competency of the workers and the level of competency required by the
organization.Tesi
N-S chart honours project report : a Nassi-Scneiderman cartographer
No full textThis project involved the development of N-S Chart; a NassiShneiderman
Cartographer for the Apple Macintosh. N-S Chart is a tool
for drawing and maintaining Nassi-Shneiderman diagrams, and
incorporates the beneficial features of diagramming methods, and
automated computer graphics tools discussed in chapters 2 and 3. The
features of N-S Chart are discussed in chapter 7. Nassi-Shneiderman
charts (N-8 Charts), an alternative to the flowchart, are described in
chapter 5. A cartographer is someone who works with charts.
In the process of implementing the original Nassi-Shneiderman
diagramming technique, modifications and improvements to the method
were developed and implemented.
Flowcharts were designed in the days of 2nd generation languages.
They do not support the constructs used in todays 3GLs and 4GLs. NassiShneiderman
charts do.
However the original Nassi-Shneiderman diagrams did have a few
drawbacks which prevented them from becoming more widely used than
they have been. The problems of data specification and drawability have
been addressed in this project and successful solutions have been found.
Chapter 8 describes aspects of user interface design. Symbols have been
added to the drawing technique to support the specification of data inputs
and outputs. Symbols have been modified to clarify charts and the
drawing and maintenance process has been automated and simplified to
an almost trivial level. Details of the implementation of N-S Chart are
discussed in chapter 9 and possibilities for further extension are
mentioned in chapter 10
N-S chart honours project report : a Nassi-Scneiderman cartographer
No full textThis project involved the development of N-S Chart; a NassiShneiderman
Cartographer for the Apple Macintosh. N-S Chart is a tool
for drawing and maintaining Nassi-Shneiderman diagrams, and
incorporates the beneficial features of diagramming methods, and
automated computer graphics tools discussed in chapters 2 and 3. The
features of N-S Chart are discussed in chapter 7. Nassi-Shneiderman
charts (N-8 Charts), an alternative to the flowchart, are described in
chapter 5. A cartographer is someone who works with charts.
In the process of implementing the original Nassi-Shneiderman
diagramming technique, modifications and improvements to the method
were developed and implemented.
Flowcharts were designed in the days of 2nd generation languages.
They do not support the constructs used in todays 3GLs and 4GLs. NassiShneiderman
charts do.
However the original Nassi-Shneiderman diagrams did have a few
drawbacks which prevented them from becoming more widely used than
they have been. The problems of data specification and drawability have
been addressed in this project and successful solutions have been found.
Chapter 8 describes aspects of user interface design. Symbols have been
added to the drawing technique to support the specification of data inputs
and outputs. Symbols have been modified to clarify charts and the
drawing and maintenance process has been automated and simplified to
an almost trivial level. Details of the implementation of N-S Chart are
discussed in chapter 9 and possibilities for further extension are
mentioned in chapter 10
Diagnóstico organizacional de la función de producción para realizar un plan de mejora en la productividad y seguridad industrial de la Planta Industrial en la Empresa L&S Nassi SAC
No full textLa presente investigación tiene como propósito realizar un diagnóstico y evaluación organizacional de la función de producción en la planta industrial de la empresa L&S NASSI SAC, así como, elaborar un plan de mejora para optimizar la productividad y seguridad industrial.
La metodología aplicada ha permitido conocer la situación real de la empresa, descubrir problemas y áreas de oportunidad para fortalecer su función de producción.
Para el logro eficaz del diagnóstico, se realizaron reuniones con la alta dirección de la empresa mostrando su conformidad e intención de cambio para aplicar las sugerencias del plan de mejora.
En este proceso, se generó información a través de entrevistas y cuestionarios, luego se procedió a almacenar los datos y el ordenamiento de la información para su posterior análisis e interpretación para responder a las cuestiones planteadas en nuestra investigación.The present investigation has as intention realize a diagnosis and
evaluation organizational of the function of production in the industrial
plant of the company L&S NASSI SAC, as well as, elaborate a plan of
improvement to optimize the productivity and industrial safety.
The applied methodology has allowed to know the royal situation of the
company, to discover problems and areas of opportunity to strengthen
his function of production.
For the effective achievement of the diagnosis, meetings were realized
by the high direction of the company showing his conformity and
intention of change to apply the suggestions of the plan of improvement.
In this process, information was generated across interviews and
questionnaires, then one proceeded to store the information and the
classification of the information for his later analysis and interpretation to
answer to the questions raised in our investigation.Tesi
L’applicazione della fire protection engineering nell’analisi antincendio del complesso monumentale del S. Maria della Scala in Siena
No full textIn contesti architettonici complessi può risultare estremamente difficile, specialmente nel caso di realizzazione di nuove attività, l'applicazione di normative antincendio di tipo deterministico, che rischiano, di fatto, di limitare le posibilità di recupero. Una corretta applicazione della fire engineering, in particolare per complessi monumentali estremamente articolati come quello in esame (Santa Maria della Scala in Siena) permette di avvalorare e verificare le ipotesi progettuali. Il lavoro presenta un'applicazione innovativa della fire engineering che oltre a fornire un supporto alle richeiste di deroga normativa offre importanti indicazioni progettuali per il recupero
SINTESI E VALUTAZIONE BIOLOGICA DI NUOVI AGENTI POTENZIALMENTE UTILI NELLA TERAPIA DEL MELANOMA MALIGNO
No full textMalignant melanoma is an extremely aggressive tumour, which originates from the neoplastic transformation of melanocytes. The therapy of metastatic melanoma, whose incidence is dramatically increasing, continues to be a challenge since, regardless of the treatment approach used (chemotherapy, immunotherapy or immuno-chemotherapy), a long-term survival is quite uncommon.
In an attempt to improve the effectiveness of the anticancer drugs currently available and to decrease their systemic toxicity, in addition to exploit some biochemical characteristics rather specific of the melanoma cells, a useful approach might be also the use of prodrugs, targeted to the tumor cells, that would release the active drug directly into the tumor mass and/or their surrounding extracellular environment.
Aim of my Ph.D. work was the synthesis and the biological evaluation of three types of new compounds, designed as possible agents useful in an anti-melanoma therapy.
The first compound, which we synthesized and tested, was a peptide-paclitaxel conjugate containing three functional domains: a “targeting domain”, an “activation sequence” and the cytotoxic agent paclitaxel. The “targeting domain”, whose function was to direct the conjugate to the tumour mass, was represented by a cyclic peptide containing the RGD sequence that can bind selectively the αVβ3 integrin, a surface molecule overexpressed by both metastatic human melanoma cells and endothelial cells of tumour vessels. The “activation sequence”, which should allow a selective release of paclitaxel within the tumour mass, was represented by a short peptide, substrate of cathepsin B (a lysosomal and pericellular protease highly up-regulated in malignant tumours, including human melanomas). The third functional domain consisted of the anticancer drug paclitaxel.
The second type of prodrug, which we designed and tested, was a 4-mercaptophenol derivative, containing a butenone moiety, the 4-[(4-hydroxyphenyl)sulfanyl]-3-buten-2-one, obtained in its E and Z geometric isomers. This compound has been designed considering that: a) the 4-mercaptophenol moiety would be a good substrate for tyrosinase, an enzyme expressed at high levels in melanoma cells, where it is involved in the biosynthesis of melanin, and able to oxidize a variety of natural and synthetic phenols, giving rise to alkylating and cytotoxic o-quinones; b) an α,β unsaturated side chain, reactive towards GSH (present in relatively high concentrations in melanoma cells) would decrease cellular antioxidant defense against the oxygen free radicals (ROS) generated as by-products during melanin synthesis, in normal as well in tumor cells. Therefore, our prodrug should act as a bifunctional agent, capable of generating cytotoxic o-quinone species (following its oxidation by tyrosinase) and reducing GSH levels.
A third part of the present work has focused on the study of the naftoquinone alkannin and its two acetylated derivatives (1’-acetyl alkannin and 5,8,1’-triacetyl alkannin), as potential inhibitors of the human glutathione-S-transferase (GST) P1-1. This enzyme, which catalyzes the conjugation of GSH to a wide range of nucleophilic compounds, is expressed at high levels in many tumor cells, including melanoma cells, and is considered one of the factors responsible of tumor resistance towards anti-cancer agents. Therefore, a specific inhibitor of this enzyme could be useful in cancer therapy, making the tumor cells more sensitive to chemotherapeutic agents.Il melanoma maligno è un tumore molto aggressivo, la cui incidenza è in costante aumento, che origina dalla trasformazione di cellule chiamate melanociti. La terapia del melanoma metastatico continua ad essere una difficile sfida, in quanto, indipendentemente dall’approccio terapeutico utilizzato (chemioterapia, immunoterapia o immuno-chemioterapia), i soggetti affetti raramente presentano una sopravvivenza a lungo termine. Per migliorare l'efficacia dei farmaci antitumorali attualmente disponibili e per diminuirne la tossicità sistemica, oltre a sfruttare alcune caratteristiche biochimiche relativamente specifiche delle cellule tumorali, e del melanoma in particolare, un approccio utile potrebbe anche essere quello di indirizzare verso le cellule tumorali dei profarmaci, che rilascino il farmaco attivo direttamente all’interno della massa tumorale e/o nel loro intorno extracellulare.
I risultati riportati in questa tesi si riferiscono alla sintesi e alla valutazione biologica di tre nuovi tipi di composti progettati in questa ottica verso le cellule di melanoma.
Il primo composto studiato è stato un coniugato peptidico del paclitaxel contenente tre domini funzionali: un dominio di "indirizzamento", una sequenza di "attivazione" e il paclitaxel, appunto, quale agente citotossico. Il dominio di “indirizzamento", la cui funzione era quella di dirigere il coniugato verso la massa tumorale, era rappresentato da un peptide ciclico contenente la sequenza RGD, in grado di legarsi selettivamente e con alta affinità all’integrina αVβ3, una molecola di superficie sovra-espressa sia dalle cellule di melanoma che dalle cellule endoteliali dei nuovi vasi tumorali. La sequenza di “attivazione ", che avrebbe dovuto consentire un rilascio selettivo del paclitaxel all’interno della massa tumorale, era rappresentata da una sequenza peptidica substrato della catepsina B, una proteasi a localizzazione lisosomiale e associata a membrana, altamente sovraespressa in molti tumori, compreso il melanoma. Il terzo dominio funzionale era costituito dal farmaco antitumorale vero e proprio, cioè dal paclitaxel, il cui legame con il peptide - nelle aspettative - avrebbe dovuto causarne la momentanea inattivazione fino al momento della sua effettiva liberazione in sede tumorale.
Il secondo profarmaco testato è stato un derivato del 4-mercaptofenolo contenente una catena laterale butenonica, il 4-[(4-idrossifenil)sulfanil]-3-buten-2-one, ottenuto nei suoi due isomeri geometrici E e Z. Questo composto è stato progettato considerando che: a) la parte derivata dal 4-mercaptofenolo avrebbe dovuto essere un buon substrato per l’enzima tirosinasi (TYRase), un enzima espresso ad alti livelli nelle cellule di melanoma, perchè coinvolto nel processo di biosintesi della melanina, e in grado di ossidare una varietà di fenoli naturali e di sintesi, dando luogo a forme alchilanti e citotossiche come gli o-chinoni; b) la catena laterale butenonica (α,β insatura), essendo dotata di elevata reattività nei confronti del GSH, presente in concentrazioni relativamente elevate nelle cellule di melanoma, avrebbe dovuto sottrarre GSH alla cellula stessa, indebolendone di fatto le difese antiossidanti nei confronti dei radicali liberi dell’ossigeno (ROS) che si generano, come sottoprodotti, durante la sintesi di melanina sia in cellule normali che tumorali. Nelle aspettative, il profarmaco così progettato si sarebbe dovuto comportare come un agente bifunzionale in grado di formare o-chinoni citotossici in seguito alla sua ossidazione da parte della tirosinasi e in grado di ridurre al tempo stesso i livelli di GSH.
Infine, un terzo approccio ha riguardato lo studio dell’alcannina (colorante naturale a struttura naftochinonica) e di due suoi derivati acetilati, quali possibili inibitori dell’enzima umano glutatione-S-transferasi (GST) di tipo P1-1, enzima espresso ad alti livelli in molti tumori tra cui appunto il melanoma. GSTP1-1 è un enzima coinvolto nel metabolismo di fase II degli xenobiotici, in quanto catalizza la coniugazione del GSH ad una vasta gamma di composti nucleofili, ma esso è anche ritenuto uno dei fattori promuoventi la farmaco-resistenza del tumore. Un inibitore specifico di questo enzima potrebbe essere quindi estremamente utile in una terapia antitumorale, rendendo le cellule tumorali più sensibili agli agenti chemioterapici
N-S Chart User's Guide
No full textThe N-S Chart program is a Nassi-Shneiderman Diagram development tool. This manual, N-S Chart User Guide, shows you how to use the various parts of the program. It does not teach you how good Nassi-Shneiderman diagrams should be drawn. • If you want a brief lesson on getting started with N-S Chart, see "Learning About N-S Chart." You should be able to follow this chapter easily, even if you've never drawn a Nassi-Shneiderman chart before.
• For more detailed information on how to use N-S Chart, look through chapter 2: Using N-S Chart.
• For a brief summary of the various features of N-S Chart, see chapter 3: Reference.
If you are wanting more detailed information about the program, refer to the separate volume "N-S Chart Project Report"
Environmental factors affecting productivity, indican content and indigo yield in Polygonum tinctorium Ait., a subtropical crop grown under temperate conditions
No full textPolygonum tinctorium Ait. is a herbaceous subtropical annual plant, belonging to the family Polygonaceae. Within the cells of its leaves P. tinctorium accumulates large amounts of a colorless glycoside, indican (indoxyl β-D-glucoside), from which the blue dye indigo is synthesized. P. tinctorium is well-known in Japan, where it had been cultivated to produce natural indigo for textile dyeing, whereas it represents a potentially interesting new crop in Europe. To better understand the effects of environmental parameters on P. tinctorium crop production and indigo yield, field experiments were carried out in central Italy under temperate climate. Three lines were tested during the 2001 and 2002 growing seasons, and plant/leaf yields as well as indican contents were evaluated. The results showed that P. tinctorium grown in temperate climate conditions can be harvested three times a year. Yields of 82 and 120 t ha-1 of fresh plant yield were obtained in 2001 and 2002, respectively. The contrasting weather conditions between the two years significantly affected biomass production, which was higher in the 2002 season, characterized by wet weather conditions. The cycle length from sowing to the last harvest was accomplished in 229-238 days when plants had accumulated 2017-2018 °C. Green leaves accounted for 40-45% by weight of fresh plant tissue and contained 11-20 g kg-1 indican. The three lines did not significantly differ in the main productive parameters or in fresh leaf indican content (14.1 g kg-1 mean value). Photosynthetic active radiation influences indican leaf production according to the model y= 0.0004x + 8.566 (P < 0.01, correlation coefficient =0.818). Indican content ranged from 12 to 25 g kg-1 of fresh leaves with PAR daily values from 10000 to 40000 mEinstein m-2 (recorded in May and at the end of July-beginning of August, respectively). The results indicate that in nonlimiting rainfall conditions a very high indican content and a potentially high indigo yield can be obtained by cultivating P. tinctorium in this pioneer geographical area
Damjan Bivaldov Nassi (cca 1338 – 1408) – a nobleman of Zadar
No full textZadnja dva desetljeća XIV. i početak XV. st. vrijeme je velikih perturbacija u Hrvatsko-Ugarskom Kraljevstvu. To je razdoblje od smrti kralja Ludovika pa do potpadanja Dalmacije pod mletačku vlast. Na ovim prostorima središte tih događanja predstavlja Zadar koji odražava sve one složene tendencije koje potresaju Kraljevstvo. Jedan od karakterističnih likova koji su bili akteri svih tih zbivanja, pa stoga lijepo dočarava odnos svih tada relevantnih političkih silnica, jest zadarski plemić Damjan Nassi. No, on je samo jedan iz najužeg kruga gradskog vrha, izabran zbog šarolikosti građe koja ga spominje. Njegov curriculum vitae zrcali glavne točke u presjeku kroz vrijeme u kojem je živio, počevši od ranih dodira s Karlom Dračkim za njegova boravka u Zadru sedamdesetih godina XIV. st. i poslova s najvećim firentinskim trgovcem solju i novčarom Petrom Monetarom, preko brojnih veza s drugim dalmatinskim gradovima, posebno Dubrovnikom, te njegove vodeće uloge u pobiranju kraljevskog poreza tridesetine i soli za cijelu Dalmaciju do udjela u politici, najprije u gušenju paške pobune, a zatim na znamenitim saborima u Ninu 1396. i Kninu sljedeće godine te konfiskacije njegove kuće i posjeda u Zadru od kralja Ladislava, očito kao Sigismundovu čovjeku, i konačnog izgnanstva iz rodnoga grada.The last two decades of the 14th century and the beginning of the 15th century were marked by major perturbations in the Croato-Hungarian Kingdom. This period covered the time from the death of King Ludovik to the time Dalmatia fell under Venetian power. In these parts, the centre of key events was Zadar, which reflected all those complex tendencies having been shaking the Kingdom. Damjan Nassi, a nobleman of Zadar, was one of the characteristic protagonists of all those events, portraying nicely the relationships among all the relevant political streamings of that time. He was however one of the highest city officials, to which fact diverse documents mentioning him witness. His curriculum vitae reflects the main issues in the cross-section of the time he lived in, starting from early contacts with Karlo Drački during his stay in Zadar in the 1370s, and business with Petar Monetaro, the greatest Florentine trader in salt and financier; continued by links with other towns in Dalmatia, especially Dubrovnik; to his leading role in collecting royal tax in the height of one thirtieth and salt for the whole Dalmatia, and his involvement in politics. The latter ranges from crushing the rebellion on Pag and the engagement in the famous synods in Nin in 1396 and Knin in 1397. His house and property in Zadar were later confiscated by King Ladislav – evidently because he was Sigismund’s man; he was in the end exiled from his hometown
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