1,259 research outputs found
First person – Simona Amodeo
No full textABSTRACT
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Simona Amodeo is the first author on ‘Characterization of the novel mitochondrial genome replication factor MiRF172 in Trypanosoma brucei’, published in Journal of Cell Science. Simona is a PhD student in the lab of Torsten Ochsenreiter at the Institute of Cell Biology, University of Bern, Switzerland, investigating mitochondrial genome anchoring, replication and inheritance in Trypanosoma brucei.</jats:p
Architettura rurale. La memoria del paese. Book of Abstracts
No full textBook of abstract della Conferenza internazionale, ICOMOS Italia Comitato Scientifico Nazionale Architettura Vernacolare 21-22 maggio 2022 / Book of Abstract of the International Conference, ICOMOS Italy National Committee CIAV May 21-22, 2022
A cura di/Edited by:
Beatrice Messeri - Marta Casanova - Valentina Cinieri - Rosa Fiorillo - Federica Pompejano - Maria Vitiello - Simona Messina
Con il patrocinio di/Under the patronage of:
Intbau Italia (International Network for Traditional Building, Architecture & Urbanism)
Associazione Storia della Città (Centro internazionale di studi per la storia della città, fonti d’archivio e patrimonio architettonico-ambientale)
Parco Regionale dell’Appia Antica
Università degli Studi di Salerno, Dipartimento di Scienze del Patrimonio Culturale
Ordine degli Architetti, Pianificatori, Paesaggisti e Conservatori di Roma e Provincia
Ordine degli Architetti, Pianificatori, Paesaggisti e Conservatori della Provincia di Firenze
Ordine degli Architetti Pianificatori Paesaggisti e Conservatori della Provincia di Avellino
Ordine degli Architetti, Pianificatori, Paesaggisti e Conservatori di Napoli e Provincia
Comitato Scientifico/Scientific Committee:
Beatrice Messeri - Giuseppe Amoruso - Alessandro Camiz - Marta Casanova - Claudio Caserta - Valentina Cinieri - Rosa Fiorillo
Simona Messina - Antonella Nappo - Federica Pompejano - Alessandra Trivelli - Maria Vitiello
Contatti/Contacts: [email protected]
Tutti gli abstracts di questo volume hanno avuto una doppia peer-review da parte del Comitato Scientifico/ All the abstracts in this volume were
double peer-reviewed by the Scientific Committe
Abstract 755: FK506 binding protein 51 (FKBP51) binds to p300 and acts as transcriptional co-regulator of ABCG2 gene expression in melanoma.
No full textMateriali e discussioni per l'analisi dei testi classici. Indici 1-60
No full textIl volume raccoglie e riassume tutti gli articoli apparsi nei volumi 1-60 della rivista «Materiali e discussioni per l’analisi dei testi classici» («MD»), nel periodo compreso tra il 1978 e il 2008. Esso è diviso in tre parti. Nella prima sono riportati in successione i singoli numeri della rivista, con il relativo sommario. Nella seconda compaiono gli articoli riuniti in sequenza cronologica, sotto il nome dell’Autore e ognuno con un proprio numero d’ordine: di ogni articolo è fornito il sunto, con i concetti, le argomentazioni salienti, i principali luoghi discussi. Nella terza parte sono elencati gli Autori antichi e i Nomi e parole notevoli, con il rinvio al numero d’ordine dell’articolo. Le schedature dei numeri 1-30 sono curate da Andrea Cucchiarelli, quelle dei numeri 31-60 da Simona Fortini.The volume collects and summarizes all the articles published in Volumes 1-60 of the journal "Materiali e discussioni per l’analisi dei testi classici” ("MD"), in the period between 1978 and 2008. It is divided into three parts. In the first part the individual issues of the journal are summarized with the table of contents. In the second part the articles appear in chronological order, under the name of the author and each with its own serial number: each item is provided with a summary including the main points of argumentation and the loci discussed. The third part contains the indexes of the ancient authors, of the names and of the most relevant things and words, with reference to the number of the item. The profiling of the numbers 1-30 is cared for by Andrea Cucchiarelli, those of the numbers 31-60 by Simona Fortini
Boccaccio nel Seicento: censure e recuperi della "compassione"
No full textSIMONA MORANDO, Boccaccio in the sixteenth century: censorship and recovery ofthe «compassion»
In the introduction of this paper, the literature of the seventeenth century is defined as a writing of compassion but not of consolation (quotations from Giovanni Cisano, Torquato Accetto, Emanuele Tesauro, G. B. Marino). The distance between the
writers studied here and Boccaccio is due to the censored editions of the Decameron in sixteenth century, to the censorship of Boccaccio as a «maestro d’amore», to his unrefined language, to his interpretation by many critics as a light and burlesque author. But, as reported in a writing by Boccalini, Boccaccio’s Latin works are very much appreciated in seventeenth century literature. This is especially the case of De casibus virorum illustrium, a gloomy and pessimistic book about misfortunes of famous men and about compassion, which nevertheless believes in the ability of letters to give back fame to ruined men. As shown in the conclusion
through some writings by Tassoni, many other seventeenth century authors do not have this kind of hope
Cellular and molecular background underlying the diversity in therapeutic responses between primary tumours and metastases.
No full textMetastasis, also called secondary neoplastic disease, is a tumour newly formed in a site different from that of origin, as a consequence of cancer progression and dissemination largely through blood and lymphatic vessels. The ability to form metastases is the main property that distinguishes malignant from benign tumours. Treatments for metastatic cancer are similar in practice to those for primary tumours, but such treatments are mostly palliative; indeed, almost all deaths caused by solid tumours occur in the metastatic phase. Increasing evidence supports the concept that therapies for primary tumours are inadequate to treat metastasis and can even promote formation of metastases, while exerting local growth control. Furthermore, recurrent tumours, which are denoted by increased aggressiveness and therapy resistance in comparison with the primary tumour, have an increased metastatic potential. Genetic modifications occurring during tumour progression lead to substantial differences between the primary and metastatic tumours. This emphasises the importance of designing novel therapies for metastasis. In the last decade, a number of studies have contributed to the understanding of the genetic rearrangements underlying the conversion of cancer cells into the metastasis founder cells. The present article aims at reviewing recent advances in metastasis research and attempts to discuss the reasons for which the therapeutic strategies against primary tumours may not satisfactorily address their metastatic counterparts
The emerging role of large immunophilin FK506 binding protein 51 in cancer.
No full textFK506 binding protein 51 (FKBP51) is an immunophilin physiologically expressed in lymphocytes. Very recently, aberrant expression of this protein was found in melanoma; FKBP51 expression correlates with melanoma aggressiveness and is maximal in metastatic lesions. FKBP51 promotes NF-␣B activation and is involved in the resistance to genotoxic agents, including anthracyclines and ionizing radiation. FKBP51 is a cochaperone with peptidyl-prolyl isomerase activity that regulates several biological processes through protein-protein interaction. There is increasing evidence that FKBP51 hyperexpression is associated with cancer and this protein has a relevant role in sustaining cell growth, malignancy, and resistance to therapy. There is also evidence that FKBP ligands are potent anticancer agents, in addition to their immunosuppressant activity. In particular, rapamycin and its analogs have shown antitumor activity across a variety of human cancers in clinical trials. Although, classically, rapamycin actions are ascribed to inhibition of mTOR, recent studies indicate FKBP51 is also an important molecular determinant of the drug’s anticancer activity. The aim of this article is to review the functions of FKBP51, especially in view of the recent findings that this protein is a potential oncogene when deregulated and a candidate target for signaling therapies against cancer
Come misurare l’efficacia di un Corso di Laurea
No full textObiettivo del presente lavoro e definire delle metodologie di valutazione dell’ effi- `
cacia di un corso di laurea che consentano di identificare le aree critiche e attivare
leve di miglioramento. Nello specifico l’indagine pilota si propone di delineare
possibili scenari di miglioramento per il CLAS, Corso di LAurea in Statistica e
informatica per l’economia e le imprese, dell’Universita Federico II di Napoli. `
Si e scelto di studiare il principale effetto di un corso universitario “efficace”: `
l’inserimento nel mondo del lavoro.
Approfondendo le differenti rilevazioni sugli sbocchi occupazionali dei laureati (ISTAT, AlmaLaurea, Stella), preliminarmente e a fini di confronto e di contestualizzazione, si e cercato di dare risposta all’interrogativo di base: cosa si intende `
per “occupato”? Come viene calcolata la percentuale dei laureati occupati
Urethral duplication in male epispadias: a very uncommon association
No full textBACKGROUND: Urethral duplication associated with epispadias is a rare malformation. Few cases are described in Literature. We report the experience of two centers to add to the literature.METHODS: A retrospective study was conducted in two Italian Centers. All patients with urethral duplication associated with epispadias, treated from 1997 to 2017 were included. The preoperative work-up included renal-urinary ultrasonography and voiding cystourethrogram. All . patients underwent surgery according to the Mitchell-Caione technique. Cosmetic result, urinary continence and satisfaction degree of patients at the last follow-up were evaluated as outcomes. Six male patients with urethral duplication in epispadias were included. Two patients presented penile epispadias and four penopubic epispadias. Only one patient had urinary incontinence as presenting symptomatology. The diagnosis of urethral duplication was accidental during preoperative evaluation in the remaining five patients.RESULTS: At last follow-up (mean 8.3 years) all patients but one presented good cosmetic result, one patient presented mild stress urinary incontinence, one presented nocturnal enuresis. The physical genital appearance was improved in all patients. Urethral duplication in association with epispadias is a rare urogenital abnormality. No classification is universally accepted.CONCLUSIONS: Based on our experience, we believe that the presence of any duplication should be carefully searched during surgery for male epispadias
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