1,820 research outputs found
Fundamentals of Material Design Culture
No full textThis essay is published in the book Ideas and the Matter, edited by Marinella Ferrara and Giulio Ceppi. The book presents the founding research undertaken by the Politecnico di Milano’s Material Design Culture Research Centre (Madec). Founded in 2014, Madec obtained the Design Department’s support during its first year by being granted the Fondo di Ateneo per la Ricerca di Base (FARB 2013) for “Fundamental/Foundational/ Exploratory Researches that are strategically assessed for scientific growth in a research department”. In the third section of the book, scientific discourse focuses on the Material Design Culture and changing approach in term of the evolution of research methods. In the chapter "Fundamental of Material Design Culture", the author traces the fundamentals of Material Design based on the Italian design history and its relationship with global design discourse
Shifting to Design-driven Material Innovation
No full textThis essay is published in the book Ideas and the Matter, edited by Marinella Ferrara and Giulio Ceppi. The book presents the founding research undertaken by the Politecnico di Milano’s Material Design Culture Research Centre (Madec). Founded in 2014, Madec obtained the Design Department’s support during its first year by being granted the Fondo di Ateneo per la Ricerca di Base (FARB 2013) for “Fundamental/Foundational/ Exploratory Researches that are strategically assessed for scientific growth in a research department”. In the third section of the book, scientific discourse focuses on the Material Design Culture and changing approach in term of the evolution of research methods. In this chapter, the author analyses several changes in the design discipline and in the approaches to Material design and explores the new dimension of the contemporary trend of material innovation driven by design competences
Ferrara città creativa
No full textIl saggio indaga il tema della creatività urbana a partire dall’illustrazione di tre pratiche locali sbocciate all’improvviso a Ferrara a partire dal 2012. Il recente fenomeno di creatività che si è manifestato a Ferrara viene messo in relazione con i risultati di trent’anni di politiche culturali e per il turismo promosse dalla città. In conclusione vengono sviluppate alcune considerazioni sia sulle pratiche illustrate, sia sulle condizioni generali per favorire questo tipo di sviluppiThe essay explores the theme of urban creativity from the illustration of three local practices suddenly blossomed in Ferrara from 2012. The recent phenomenon of creativity that is manifested in Ferrara is put in relation by the author with the results of thirty years of cultural and tourism policies promoted by the City. In conclusion, some considerations are developed both on the practices discussed, both on the general conditions to encourage this type of development
Amazonian plants from ethnomedicine to biotechnology through pharmaceutical biology approaches: a PhD experience in connecting forest with laboratory
No full textThe South american Natives, Shuar and Achuar people and their ethnomedical culture constitute the
background subject of the Phd research, performed both in Ecuador (Salesian Politechnic University,
Quito), and in Italy (Pharmaceutical biology labs, University of Ferrara). Based on ethnomedical
responses, Piper aduncum, Maytenus macrocarpa, Schinus molle, Tecoma stans and Eugenia hallii were
chosen as amazonian plant species subject of the research.
AIMS
The research has been focused on:
− checking the presence of endophytic fungi in plants;
− isolating and subculturing pure endophytic strains;
− checking the biotransformation capacity of the isolated endophytes on pure compounds; the most
performing endophytes were also tested on phytocomplexes and pure chemicals obtained by the
plant from which the fungi were isolated;
− phytochemical characterization and bioactivity assays of plant extracts: P. aduncum.
−
METHODS
Biotransformations. Fresh aerial plant parts were properly washed in sanitizing solutions and in vitro
cultured using adequate solid media to isolate endophytes. (+/-)-cis-bicyclo[3.2.0]hept-2-en-6-one,
acetophenone, 1-indanone, 2-furyl methyl ketone, 2-methylcyclopentanone, 2-methylcyclohexanone, 2-
methoxycyclohexanone were chosen as substrate model for biotransformations. The cultures were
sampled after 1, 3, 7, 10 days of culturing, and ethyl acetate extracted to verify by GC-MS the presence of
possible biotransformation products. Biotransformations were also checked on P. aduncum whole
essential oil and on dillapiol, cis-ocimene, piperitone, (-)-terpinen-4-ol as most abundant chemicals.
Chemical fingerprinting of P. aduncum essential oil. Steam distillation was adopted to obtain the essential
oil, then characterized by GC-MS, NMR analyses.
In vitro bioassays of P. aduncum essential oil. Antimicrobial activities were checked in vitro using proper
agarized media to reach MIC. Antioxidant capacities were checked through DPPH test, ABTS and
photochemiluminescence assays. Born's turbidimetric method and Writhing test were respectively
adopted to check platelet-aggregation and anti-nociceptive properties. Mutagenic, antimutagenic
properties and toxicity were assayed using classical and modified Ames test.
MAIN RESULTS
364 fungal strains were in vitro isolated. Among all, 5 strains performed biotransformations on
acetophenone to (S)-1-phenylethanol, with important yields (78-97%) and enantiomeric excess (78-
100%). Three strains gave also phenols probably by enzymatic reactions (Baeyer-Villiger oxidations). 15
fungal strains gave the lactones (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one and (-)-(1R,5S)-3-
oxabicyclo[3.3.0]oct-6-en-2-one from (+/-)-cis-bicyclo[3.2.0]hept-2-en-6-one, probably as result of
monooxygenase activation. Phytochemical characterization of P. aduncum essential oil has evidenced
dillapiol as the most abundant terpene, followed by cis-ocimene, piperitone and terpinen-4-ol. Only cisocimene
and piperitone gave several biotransformation products through dehydrogenation and
hydroxylation reactions. The essential oil has evidenced non-mutagenic properties and interesting
antifungal and antioxidant activities.
CONCLUSIONS
Several endophytic fungal strains from Amazonian plants were isolated and checked for
biotransformations on pure chemicals and on P. aduncum essential oil. Data obtained will be useful for
possible following patents about micro-organisms able to transform pharmaceutically interesting
chemicals. Taxonomical characterization of the most performing fungal strains is still in progress. P.
aduncum essential oil can be considered genotoxically safe and provides interesting antifungal and
antioxidant properties, supporting its ethnomedical use as cicatrising and disinfectant crude drug and
suggesting an extension of its employ as preservative ingredient
Correction to: Curve of Spee modification in different vertical skeletal patterns after clear aligner therapy: a 3D set-up retrospective study (Progress in Orthodontics, (2024), 25, 1, (5), 10.1186/s40510-023-00503-1)
No full textCorrection to: Prog Orthod.25, 5 (2024) https://doi.org/10.1186/s40510-023-00503-1. Following publication of the original article [1], the authors identified an error in the author names of the author group as the given name and family name were erroneously transposed. The incorrect author names are: Ciavarella Domenico, Fanelli Carlotta, Suriano Carmela1, Campobasso Alessandra, Lorusso Mauro, Ferrara Donatella, Maci Marta, Esposito Rosa and Tepedino Michele The correct author names are: Domenico Ciavarella, Carlotta Fanelli, Carmela Suriano, Alessandra Campobasso, Mauro Lorusso, Donatella Ferrara, Marta Maci, Rosa Esposito and Michele Tepedino The author group has been updated above and the original article [1] has been corrected
Nuclear Medicine Imaging of Joint Prosthesis Infection
No full textThis comprehensive pictorial case-based atlas of radionuclide imaging in infection and inflammation comprises a diverse group of excellent cases, many using hybrid SPECT/CT and PET/CT imaging. The cases cover a wide spectrum of infection and inflammation in multiple organ systems from brain to feet, including bone, soft tissues, lung, liver, spleen, heart and major vessels, fever of unknown origin, prosthetic joint and implanted devices, vascular grafts, catheter infections, and infections related to hardware in bone. Infections and inflammation associated with chronic inflammation in diseases such as rheumatoid arthritis, sarcoidosis, Sjögren’s disease, vasculitis, and atherosclerosis are also included. The imaging is with commercially and routinely available radiopharmaceuticals such as 67Ga-citrate or the newer 18F-FDG in PET imaging, and 111In-oxine or 99mTc-hexamethylpropyleneamine oxime (Ceretec; GE Healthcare)–labeled white blood cells, 3-phase bone and sulfur colloid bone marrow scanning, and monoclonal antibodies.
The book is divided into 13 chapters covering a wide spectrum of infection and inflammation imaging in the entire body. It is the end result of collaborative hard work by many medical professionals from medical centers throughout Italy, through their involvement in the study group on inflammation and infection of the Italian Association of Nuclear Medicine. Some cases in this atlas are not routinely or frequently seen in a general nuclear medicine practice and thus can serve as a good go-to reference
Guida pel forestiero in Ferrara /
No full textOn spine: Guida di Ferrara.Includes bibliographical references and index.Mode of access: Internet
Memorie istoriche delle chiese di Ferrara e de' suoi borghi : munite, ed illustrate con antichi inediti monumenti, che ponno servire all' istoria sacra della suddetta città.
No full textErrata, last 2 leaves.Includes index of churches discussed.Signatures: pi⁶ A-2C⁸ 2D⁴ ²A-D⁸ E¹⁰(-E1) F-H⁸ I¹⁰(-I3)."Al benigno lettore" signed by the author, Giuseppe Antenore Scalabrini.Mode of access: Internet.Armorial property stamps with rampant lion and initial M. Blind stamp of Giannalisa Feltrinelli.Binding: mottled paper, backed in streaked goatskin, corners in sheepskin. Edges mottled blue
Political liberalism revisited. A paradigm for liberal democracy in the 21st century
No full textIn this article by way of reply, the author responds to the challenging comments on The Democratic Horizon provided by Michelman, Benhabib, White, Scheuerman and Laden. In response to Michelman, some reflections are propounded (1) on the function of judicial review, in order to alleviate the tension between two understandings of the mandate of the highest interpreter of the constitution as aimed at remedying either an occlusion of democratic authorship or a shortfall of agreement, and (2) on the need to rethink how the authority of the supreme interpreter relates to the will of the people in a deeply changed historical context. In response to Benhabib, the author discusses the new limits of the accommodation of diversity in Fairburg, a fictional polity that expands the Rawlsian standard of ‘reasonable disagreement’, and defends the normative relevance and democratic credentials of his notion of ‘multivariate polity’. In response to White, after recalling the importance of putting the ‘democratic ethos’ at the center of a reflection on the democratic quality of complex societies where formal procedures often mask elitist substance, the author defends the ‘political, not metaphysical’ credentials of ‘openness’ (as well as of ‘exemplarity’ as the ‘upstream source’ of openness) and accepts a complementarity of ‘openness’ and ‘presumptive generosity’. In response to Scheuerman, the author restates his focus on the democratic ethos as a supplement to, not a replacement of, the reflection on democratic procedures and defends the conceptual diversity of governance from government. In response to Laden, the author highlights the diversity of contexts to which his own and Laden’s versions of ‘democratic justification’ are responding and defends a more moderate version of ‘openness’, which still keeps constitutional essentials and political values shielded from ongoing questioning. Finally, the author interprets the debate aroused by The Democratic Horizon as indicative of the persistent vitality of the Rawlsian legacy in the 21st century
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