1,720,974 research outputs found
EFFECTS OF PHOSPHATIDYLSERINE ADMINISTRATION ON AGE-RELATED STRUCTURAL-CHANGES IN THE RAT HIPPOCAMPUS AND SEPTAL COMPLEX
No full textDendritic spine density of CA1 pyramidal neurons in the hippocampus and morphometric characteristics of the cholinergic neuronal population of the septal complex, were evaluated in young (four months), aged (27 months), and age-matched rats which had received long-term phosphatidylserine (BC-PS) administration (50 mg/kg/die, suspended in the drinking water). In aged rats, spine density decreased significantly by 12.11% in the basal dendrites and by 10.64% in the apical ones, as compared with young controls. In the cholinergic neuronal population of medial septum and diagonal band, aging induced a statistically significant reduction in cell number (-19.6%), in soma area (-18.5%), in cell maximal diameter (-9.2%), and in the area covered by all cholinergic profiles (-33%). By contrast, no significant reductions in the above-mentioned structural parameters were observed in aged BC-PS-treated rats when compared with young animals. The mechanisms underlying the beneficial effects of BC-PS can possibly be ascribed to the pharmacological actions exerted by BC-PS on neuronal membranes, neurotransmission, and/or interaction with NGF
Behavioral and morpho-functional correlates of brain aging: a preclinical study with phosphatidylserine
No full textDENDRITIC SPINE DENSITY OF CA1 PYRAMIDAL CELLS IN THE HIPPOCAMPUS OF AGED RATS - EFFECTS OF PHOSPHATIDYLSERINE ADMINISTRATION
No full textDENDRITIC SPINE LOSS IN HIPPOCAMPUS OF AGED RATS - EFFECT OF BRAIN PHOSPHATIDYLSERINE ADMINISTRATION
No full textDendritic spine density of pyramidal cells in region CA1 of the hippocampus has been evaluated in young (3 months), old (27 months) and old phosphatidylserine (BC-PS)-treated rats. BC-PS (50 mg/kg, suspended in tap water) was administered daily, starting at the age of 3 months until 27 months. Spine density was analyzed on Golgi-stained pyramidal neurons by a computerized analysis system. In 27-month-old rats, spine density showed with respect to 3-month-old animals, a significant decrease in both basal and apical dendrites (p less than 0.01; one-way ANOVA), with a mean loss of 12.11% in the basal dendrites and of 10.64% in the apical ones. In 27-month-old rats treated with BC-PS, values of spine density were not statistically different when compared to those of 3-month-old animals. The mechanisms underlying the beneficial effect of BC-PS treatment on neuronal connectivity might be explained on the basis of its pharmacological actions on neuronal membranes [9], neurotransmission [43] and/or interaction with NGF [7]
Phosphatidylserine restores spatial memory and morphofunctional cholinergic markers in basal forebrain nuclei of aged rats
No full text
Morpho-functional correlates of learning and memory in aged rats. Effects of phosphatidylserine administration
No full textPosphatidylserine treatment prevents age-induced structural alterations in the rat septo-hippocampal system
No full textStructural changes of basal cholinergic neurons in the aged rat. Effect of phosphatidylserine administration
No full text
- …
