1,721,045 research outputs found
Post-thoracotomy analgesia in a cat using a manual target controlled infusion scheme for fentanyl
No full textAlfentanil nel gatti: 16 casi.
No full textIl remifentanil ha la stessa potenza analgesica del fentanil e come quest’ultimo è una fenilpiperidina. Come tutti
gli oppioidi causa una modesta depressione cardiovascolare a fronte di una marcata riduzione della MAC degli anestetici inalatori.
La breve emivita, la mancanza d’accumulo e la metabolizzazione extraorganica (avviene tramite esterasi non specifiche
presenti nel plasma e nei tessuti) sono caratteristiche non comuni ad altri analgesici iniettabil
Isolamento e caratterizzazione di clostridi butirrici in formaggi stagionati pugliesi affetti da "gonfiore tardivo"
No full text
Survey of the current use of pharmacokinetic model-driven drug delivery in small animal anaesthesia and analgesia in Italy
No full textVeterinary surgeons in Italy were surveyed about their current practice with regard to the use of propofol and intravenous opioids during anaesthesia and for treatment of acute pain in small animals Questionnaires were e-mailed to all 171 members of the Italian Society of Veterinary Regional Anaesthesia and Pain Medicine Information was requested on the type of practice the veterinarians worked in, the administration techniques used and the perceived benefit of pumps with target-controlled infusion (TCI) capability implementing small animal pharmacokinetic models A total of 168 responses were received (response rate 98 2 per cent) Of the respondents, 121 (72 0 per cent) worked in a first-opinion private practice, 25 (14 9 per cent) worked in a 24/7 private practice, 11 (6 5 per cent) worked in a referral private practice, eight (4 8 per cent) worked in a university hospital, two (1 2 per cent) were not currently practising with small animals and one (0 6 per cent) had retired Of the 130 (78 8 per cent) practising respondents who reported using a syringe pump, eight (4 8 per cent) used a TO system, 31 (18 8 per cent) used manual TCI, 40 (24 2 per cent) used a bolus-elimination-transfer scheme and 51 (31 per cent) used a constant-rate infusion As a result, 79 of 165 (47 9 per cent) practising respondents used a pharmacokinetic model-driven method of drug delivery The majority of respondents (81 2 per cent) believed that the use of pumps with TCI capability would improve practice and patient car
Propofol Target Controlled Infusion (TCI) for assessment of laryngeal function in dogs: a preliminary investigation
No full textIntroduction: The aim of the study was to investigate the use of propofol
TCI for visual examination of arytenoid motion in dogs.
Materials and methods: Seven ASA I-II dogs scheduled for examination of
laryngeal function were enrolled in a prospective study. Acepromazine
(0.02mgkg1) and morphine (0.15mgkg1) were administered intramuscularly
60minutes prior to induction. Cardiorespiratory monitoring and flowby
oxygen (0.2Lkg1 min1) were started before induction. Anesthesia was
induced with propofol using a TCI system. A 3.1mcgmL1 plasma target
was achieved, Loss-Of-Righting-Reflex (LORR) was assessed, and individual
predicted ES concentration at LORR was recorded. After induction the
individual ES concentration at LORR was targeted, and the target increased
or decreased by 0.2mcgmL1 steps until laryngoscopy was impossible or
arytenoid motion disappeared. The median (range) ES concentration at
LORR and at ‘best arytenoid motion’ were calculated.
Results: Five males and 2 females, 48 (12–72) months old, weighing 17.7
(5.4–28) kg entered the study. The median (range) propofol ES concentration
was 1.65 (1.60–2.59)mcgmL1 at LORR, and 2.1 (1.4–2.8)mcgmL1 at ‘best
arytenoid motion’. Two dogs were diagnosed with bilateral laryngeal paralysis
and elongated soft palate, respectively. Although all dogs had some spontaneous
movements of the tongue and jaw, and held their breath intermittently in
response to laryngoscopy, on no occasion there was any risk of trauma to the
examiner, the dog or the equipment. At the propofol concentration providing
the best assessment no dogs lifted the head or showed a transient Return-Of-
Righting-Reflex (RORR) after end of assessment. Hemoglobin oxygen saturation
exceeded 94%in all dogs. Heart rate lower than 60 beats-per-minute and
Mean Arterial Pressure lower than 60mmHg were not detected.
Conclusions: Propofol ES-TCI represents a useful tool for visual examination
of arytenoid motion in dogs. It provides a stable anesthetic depth,
and can be titrated according to individual response. Required propofol ES
concentration seems to be higher for laryngeal assessment than for LOR
Le difese di Aquileia nel IV secolo
No full textIl contributo illustra l'articolazione topografica e l'assetto strutturale delle fortificazioni di Aquileia nel corso del IV secolo d.C
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