197,298 research outputs found
Sizzo de Noris, Cristoforo
No full textBiografia del principe vescovo di Trento Cristoforo Sizzo de Noris (1706-1776
Opera Varia
No full textAb Eminentissimo D. F. Henrico De Noris Augustiniano Veronensi Tit. S. Augustini S. R. E. Presbytero Cardinali, & Sanctæ Sedis Apostolicæ Bibliothecario, vel proprio, vel alieno nomine edita. Quibus Doctrina In Historia Pelagiana, Dissertatione De Synodo V. & Vindiciis Augustianis Contenta, illustratur, roboratur, & defenditur. Quorum seriem sequens pagina exhibebitVorlageform des Erscheinungsvermerks: LUGDUNI, Apud ANISSONIOS, & JOANN: POSUEL. M. DCCVII
Il silenziamento dell’RNA nell’interazione pianta-virus
No full textPrefazione Il testo di Patologia Vegetale Molecolare, scritto da più di 70 autori e coordina- to da Massimo Reverberi, Lorenzo Covarelli, Michelina Ruocco e Luca Sella, rappresenta un affresco attuale delle conoscenze sull’interazione pianta-pato- geno, sulla biologia dei principali patogeni vegetali, sugli approcci sostenibili alla lotta contro le fitopatie, fino agli aspetti diagnostici molecolari più inno- vativi. Il testo si presenta diviso in 6 sezioni, in cui le prime 3 approfondiscono rispettivamente aspetti molecolari e cellulari di virus e viroidi (sezione 1), fi- toplasmi e batteri (sezione 2), oomiceti e funghi (sezione 3), mentre la quarta sezione è interamente dedicata alle interazioni molecolari pianta-patogeno e ambiente, con un focus particolare sulle principali reazioni difensive del- la pianta, locali e sistemiche, sia ai patogeni che ai principali stress abiotici. Nella quinta sezione si affrontano i temi più legati alla difesa sostenibile e allo sviluppo di innovazione nel controllo delle fitopatie (es. genome editing), mentre la sesta riporta un’ampia rassegna delle metodologie più recenti per la diagnosi delle principali fitopatie. Il libro è un testo unico nel suo genere, composto da 37 capitoli, ciascuno dei quali è stato concepito e scritto dai principali esperti dello specifico am- bito trattato, e cerca di rappresentare al meglio tutti gli aspetti della ricerca italiana nel settore dell’interazione pianta-patogeno ed in generale della Pato- logia Vegeta
STEC-HUS, atypical HUS and TTP are all diseases of complement activation
No full textHaemolytic uraemic syndrome (HUS) and thrombotic thrombocytopaenic purpura (TTP) are diseases characterized by microvascular thrombosis, with consequent thrombocytopaenia, haemolytic anaemia and dysfunction of affected organs. Advances in our understanding of the molecular pathology led to the recognition of three different diseases: typical HUS caused by Shiga toxin-producing Escherichia coli (STEC-HUS); atypical HUS (aHUS), associated with genetic or acquired disorders of regulatory components of the complement system; and TTP that results from a deficiency of ADAMTS13, a plasma metalloprotease that cleaves von Willebrand factor. In this Review, we discuss data indicating that complement hyperactivation is a common pathogenetic effector that leads to endothelial damage and microvascular thrombosis in all three diseases. In STEC-HUS, the toxin triggers endothelial complement deposition through the upregulation of P-selectin and possibly interferes with the activity of complement regulatory molecules. In aHUS, mutations in the genes coding for complement components predispose to hyperactivation of the alternative pathway of complement. In TTP, severe ADAMTS13 deficiency leads to generation of massive platelet thrombi, which might contribute to complement activation. More importantly, evidence is emerging that pharmacological targeting of complement with the anti-C5 monoclonal antibody eculizumab can effectively treat not only aHUS for which it is indicated, but also STEC-HUS and TTP in some circumstances. © 2012 Macmillan Publishers Limited. All rights reserved
Thrombotic microangiopathies: from animal models to human disease and cure
No full textThrombotic microangiopathies are a group of microvascular disorders, with reduced organ perfusion and hemolytic anemia. The two most relevant conditions characterized by thrombotic microangiopathic anemia (TMA) are thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). In TTP, systemic microvascular aggregation of platelets causes ischemia in the brain and other organs. In HUS, platelet-fibrin thrombi predominantly occlude the renal circulation. TTP can be inherited due to deficiencies in the activity of von Willebrand factor cleaving protease (ADAMTS13) or acquired due to the presence of autoantibodies directed against ADAMTS13. The majority of HUS cases are secondary to infections by strains of Escherichia coli that produce Shiga-like toxins (Stx-HUS), while about 5- 10% of all cases are classified as atypical HUS (aHUS). Genetically derived impaired regulation of the complement system is associated with aHUS. Infusion or the exchange of fresh frozen plasma have ameliorated the prognosis of TMA; however, no specific therapies aimed at preventing or limiting the microangiopathic process have been proven to affect the course of TMA. Large mammals, small animal models, knockout and transgenic mouse models of TTP and both Stx-HUS and aHUS have been developed and have provided outstanding contributions to nearly all areas of TMA research. A better understanding of the key clinical features of the diseases and of the importance of genetic and/or environmental factors involved in the pathogenesis of the diseases have been obtained. These animal models have also allowed the set up of protocols aimed at ameliorating the clinical approach to patients and for the development of new drugs and vaccines
Hemolytic uremic syndrome
No full textHemolytic uremic syndrome (HUS) is a thrombotic microangiopathy defined by thrombocytopenia, nonimmune microangiopathic hemolytic anemia, and acute renal failure. The most frequent form is associated with infections by Shiga-like toxin-producing bacteria (STEC-HUS). Rarer cases are triggered by neuraminidase-producing Streptococcus pneumoniae (pneumococcal-HUS). The designation of aHUS is used to refer to those cases in which an infection by Shiga-like toxin-producing bacteria or S. pneumoniae can be excluded. Studies performed in the last two decades have documented that hyperactivation of the complement system is the pathogenetic effector mechanism leading to the endothelial damage and the microvascular thrombosis in aHUS. Recent data suggested the involvement of the complement system in the pathogenesis of STEC-HUS and pneumococcal-HUS as well. Clinical signs and symptoms may overlap among the different forms of HUS; however, pneumococcal-HUS and aHUS have a worse prognosis compared with STEC-HUS. Early diagnosis and identification of underlying pathogenetic mechanism allows instating specific support measures and therapies. In clinical trials in patients with aHUS, complement inhibition by eculizumab administration leads to a rapid and sustained normalization of hematological parameters with improvement in long-term renal function. This review summarizes current concepts about the epidemiological findings, the pathological and clinical aspects of STEC-HUS, pneumococcal-HUS, and aHUS, and their diagnosis and management
The invasive Stellaria media (L.) Vill.(Caryophyllaceae), a critical taxon at specific and subspecific level
No full textStellaria media variations and taxonomic problems at specific and subspecific leve
Ceratolejeunea laetefusca R. M. Schust.
No full textCeratolejeunea laetefusca (Aust.) R.M.Schust. C. integrifolia A.Evans, Bulletin of the Torrey Botanical Club 38: 213 (1911). SPECIMENS EXAMINED. — Panama. Barro Colorado Island, Shattuck 4, 568 p. p. (Stotler et al. 1998); Fairchild trail 4, Dauphin 3134; Nemesia trail, Dauphin 3103; Snyder-Molino trail, Dauphin 3052; Shannon trail 0-2, Dauphin 3075. HABITAT. — On tree trunks in relatively dry, exposed sites. DISTRIBUTION. — Tropical America.Published as part of Dauphin, Gregorio, Gradstein, S. Robbert & Allen, Noris Salazar, 2022, Liverworts and hornworts of Barro Colorado Island, Panama, pp. 153-165 in Cryptogamie, Bryologie 20 (9) on page 156, DOI: 10.5252/cryptogamie-bryologie2022v43a9, http://zenodo.org/record/782257
Gauged D = 4 N = 4 supergravity
No full textAbstract We present the full Lagrangian and supersymmetry transformation rules for the gauged D = 4, N = 4 (half-maximal) supergravity coupled to an arbitrary number of vector multiplets. Using the embedding tensor formulation, the final results are universal and valid in arbitrary symplectic frames. We also analyze the conditions for the critical points of the scalar potential and specify the full spectrum of the quadratic fluctuations about Minkowski vacua. This allows us also to exclude the appearance of quadratic divergences in the 1-loop corrections to the scalar potential for any Minkowski vacuum fully breaking supersymmetry. We also provide some interesting byproducts of our analysis, like the field equations and the quadratic constraints for the fermion shifts characterizing the gauging (also known as T-tensor identities)
Leptolejeunea jamaicensis R. M. Schust.
No full textLeptolejeunea jamaicensis R.M.Schust. SPECIMENS EXAMINED. — Panama. Barro Colorado Island, Shannon trail 0-1, Dauphin 3062 p.p.; Snyder-Molino trail, Dauphin 3051; stairs to old dining hall, Dauphin 3211. HABITAT. — On living leaves. DISTRIBUTION. — Scattered in tropical America, distribution insufficiently known. REMARKS The plants were initially identified as L. maculata (Mitt.) Schiffn., but the latter species occurs in Asia and is replaced in the Neotropics by L. jamaicensis (Gradstein 2021).Published as part of Dauphin, Gregorio, Gradstein, S. Robbert & Allen, Noris Salazar, 2022, Liverworts and hornworts of Barro Colorado Island, Panama, pp. 153-165 in Cryptogamie, Bryologie 20 (9) on page 161, DOI: 10.5252/cryptogamie-bryologie2022v43a9, http://zenodo.org/record/782257
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