1,721,071 research outputs found
Soluble TRAIL coud enhance bone destruction acting on Rank-ligand in estrogen-indipendent human breast cancer cell line.
No full textSoluble TRAIL could enhance bone destruction acting on RANK-ligand in estrogen independent human breast cancer cell line MDA-MB-231.
No full textThe development and spread of tumors is associated with the ability of malignant cells to avoid detection and subsequent elimination by the immune system, to grow in non-native sites and to avoid programmed or induced cell death. In addition to the well-described role of osteoprotegerin in the regulation of bone turnover, there is an emerging evidence that osteoprotegerin may have an additional function due to its ability to bind and inhibit the members of the tumor necrosis factor (TNF)-superfamily, such as TNF-alpha and TNF-related apoptosis inducing ligand (TRAIL). We have shown that the breast cancer cell line MDA-MB-231 produces a sufficient amount of osteoprotegerin to bind TRAIL, resulting in an upregulation of receptor activator factor kappa B ligand (RANKL) expression. In conclusion, the presence of osteoprotegerin, as secreted by this cell line, acting as a paracrine factor, could affect breast cancer RANKL production inducing an enhancement of osteolysis and the perpetuatio
Targeting RANKL in the management of bone loss in patient with breast cancer
Full text linkThe receptor activator of nuclear factor-κB ligand (RANKL), its signaling receptor RANK, and its natural decoy receptor OPG are members of the tumour necrosis factor (TNF) and TNF receptor superfamily and are best known for their essential role in controlling osteoclastogen- esis. RANKL in bone has also been shown to serve as a chemoattractant for cancer cells, thus explaining the tropism of certain cancers such as breast and prostate cancer to preferentially metastasize to bone. Here, we will discuss the important role of RANKL and its possible role in the management of bone loss in patients with breast cancer
Differentiation on activated monocyte into osteoclast-like cells on a hydroxyapatite substrate: an in vitro study
No full textExpression of E-Cadherin during osteoclastogenesis using a coculture as a model of cell-cell interaction
No full textSoluble TRAIL enhanced bone destruction acting on Rank-ligand in estrogen dependent/independent human brest cancer cell lines.
No full textSoluble TRAIL enhanced bone destruction acting on Rank-ligand in estrogen dependent/independent human brest cancer cell lines
Effect of tanshinone II on cell growth of breast cancer cell line type MCF-7 and MD-MB-231
Full text linkBreast cancer is the most common form of cancer in women and the leading cause of cancer death in American women, with over 207,090 new cases of invasive breast cancer in women and about 39,840 deaths from breast cancer in 2010. Current therapies for breast cancer usu- ally have variable effectiveness with high toxicity to normal tissues, and breast tumours often develop metastasis and drug resistance. Therefore, searching for effective regimens with mini- mal side effects remains the top priority in breast cancer research. The objectives of this study were to evaluate the effects of tanshinone II from a Chinese herb, Salvia miltiorrhiza, on the growth of breast cancer cells type MCF-7 and MDA-MB-231
Osteoimmunology represents a link between skeletal and immune system
Full text linkThere is a complex interplay between the cells of the immune system and bone. These interactions are not only mediated by the release of cytokines and chemokines but also by direct cell–cell contact. Studies of intracellular signaling mechanisms in osteoclasts have revealed that numerous immunomodulatory molecules are involved in the regulation of bone metabolism. Recently, it was proposed that immunoreceptors found in the immune cells are also an essential signal for osteoclasts activation, along with receptor activator of NF-κB (RANK) ligand (RANKL). Collectively, these and similar observations regarding cross-regulation between the immune and skeletal systems constitute the field of osteoimmunology. Here we briefly highlight core areas of interest and selected recent advances in this field
The overlapping between TRAIL and OPG could contribute to an enhancement of the erosive processes induced by human synovial cells
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