1,721,016 research outputs found
Cardiovascular receptors binding affinity of aqueous extracts from Allium species
No full textThe aims of this study were to evaluate whether the antihypertensive effect of garlic could to be associated to interactions with adrenergic and dopaminergic receptors involved in regulating blood pressure and to compare these data with those obtained from wild Allium species.
Methods The aqueous extracts of bulbs or leaves of Allium sativum L. (garlic), Allium neapolitanum Cyr., Allium subhirsutum L., and Allium roseum L. were tested for their in vitro affinity for the adrenergic (a1, a2, b1 and b2) and dopaminergic (D1 and D2) receptors by radioligand binding assays.
Results Interesting results were shown by bulbs extracts of A. neapolitanum and A. subhirsutum with higher affinities for the b2 receptors and by bulbs extract of A. roseum for D2 receptors.
Conclusions The known antihypertensive activity of Allium sativum cannot be correlated with binding to receptors involved in blood pressure regulation. However, aqueous extracts of the
wild-type species of Allium show much higher affinities, warranting further explorations
Attività antiproliferativa di estratti di fusti e radici di Cucurbita ficifolia Bouché
No full text
Ultrasound evaluation of the parathyroid glands in clinically normal cats and with chronic renal failure
No full textThe purpose of this study is to characterize the sonography appearance of parathyroid glands in healthy cats and to evaluate any alteration during the course of secondary renal hyperparathyroidism. 25 healthy cats and 10 affected by chronic renal failure (CKD) were studied. For each displayed gland echogenicity and size of long and short axis were assessed. The median size of parathyroids in healthy cats were the folllowing: left cranial parathyroid 2,4x1,1mm, left caudal parathyroid 2,1x1mm, right cranial parathyroid 2,5x1,1mm, right caudal parathyroid 1,8x0,9mm. In CKD cats an enlargement of the parathyroid glands is dectable ultrasonographically; the length of the cranial and caudal left glands and cranial right gland was statistically greater in CKD cats compared to healthy cats
Protective effect of Allium neapolitanum Cyr. vs. Allium sativum L. on acute ethanol-induced oxidative stress in rat liver
No full textThis study investigated the protective effect of Allium neapolitanum Cyr., a spontaneous species of the Italian
flora, compared with garlic (Allium sativum L.) on liver injury induced by ethanol in rats. Male albino Wistar rats were orally
treated with fresh Allium homogenates (leaves or bulbs, 250 mg=kg) daily for 5 days, whereas controls received vehicle only. At the end of the experimental 5-day period, the animals received an acute ethanol dose (6mL=kg, i.p.) 2 hours before the last Allium administration and were sacrificed 6 hours after ethanol administration. The activities of catalase (CAT), superoxide dismutase (SOD), and glutathione reductase (GR) and the levels of malondialdehyde (MDA), ascorbic acid (AA), and reduced (GSH) and oxidized glutathione in liver tissue were determined. Administration of both Allium species for 5 days (leaves or bulbs) led to no statistical variation of nonenzymatic parameters versus the control group; otherwise Allium treatment caused an increase of GSH and AA levels compared with the ethanol group and a diminution of MDA levels, showing in addition that A. neapolitanum bulb had the best protective effect. Regarding to enzymatic parameters, GR and CAT activities were enhanced significantly compared with the ethanol group, whereas SOD activity showed a trend different from other parameters estimated. However, the treatment with both Allium species followed by acute ethanol administration reestablished the nonenzymatic parameters similar to control values and enhanced the activities of the enzymes measured. These results suggest that fresh Allium homogenates (leaves or bulbs) possess antioxidant properties and provide protection against ethanol-induced liver injury
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