411 research outputs found
On a reconstruction problem
No full textAbstractThis note supplements an earlier paper of this author, in which the concept of a strong k-hypomorphism between two graphs was defined (Thatte, 1990, Sectin VI). For k=1, this is just a hypomorphism. Here it is proved that strongly k-hypomorphic graphs and strongly k-edge hypomorphic directed graphs are isomorphic if k>1
A reconstruction problem related to balance equations II: The general case
No full textAbstractA modified k-deck of a graph G, first introduced in (Krasikov and Roditty, 1987), is obtained by removing k edges of G in all possible ways, and adding k (not necessarily new) edges in all possible ways. Krasikov and Roditty asked if it was possible to construct the usual k-edge deck of a graph from its modified k-deck. In (Thatte, to appear), the author solved this problem for the case when k = 1. In this paper, the problem is completely solved for arbitrary k. The proof makes use of the k-edge version of Lovász's result and the eigenvalues of certain matrix related to the Johnson graph
Fault Diagnosis of Semiconductor Random Access Memories
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Reason: Restricted to UIUC communityOpen Restriction set for Item 100821 on 2019-11-15T17:33:23Z with date null by [email protected] Services Electronics Program / DAAB-07-72-C-0259OpenCoordinated Science Laboratory was formerly known as Control Systems Laboratory"Author name appears as ""Satish Munkund Thatte"" in front matter
Provenance-based trust for grid computing: Position Paper
No full textCurrent evolutions of Internet technology such as Web Services, ebXML, peer-to-peer and Grid computing all point to the development of large-scale open networks of diverse computing systems interacting with one another to perform tasks. Grid systems (and Web Services) are exemplary in this respect and are perhaps some of the first large-scale open computing systems to see widespread use - making them an important testing ground for problems in trust management which are likely to arise. From this perspective, today's grid architectures suffer from limitations, such as lack of a mechanism to trace results and lack of infrastructure to build up trust networks. These are important concerns in open grids, in which "community resources" are owned and managed by multiple stakeholders, and are dynamically organised in virtual organisations. Provenance enables users to trace how a particular result has been arrived at by identifying the individual services and the aggregation of services that produced such a particular output. Against this background, we present a research agenda to design, conceive and implement an industrial-strength open provenance architecture for grid systems. We motivate its use with three complex grid applications, namely aerospace engineering, organ transplant management and bioinformatics. Industrial-strength provenance support includes a scalable and secure architecture, an open proposal for standardising the protocols and data structures, a set of tools for configuring and using the provenance architecture, an open source reference implementation, and a deployment and validation in industrial context. The provision of such facilities will enrich grid capabilities by including new functionalities required for solving complex problems such as provenance data to provide complete audit trails of process execution and third-party analysis and auditing. As a result, we anticipate that a larger uptake of grid technology is likely to occur, since unprecedented possibilities will be offered to users and will give them a competitive edge
Pancreaticoduodenectomy for paediatric pancreatic trauma with a decade of follow-up
No full textPancreaticoduodenal injuries are rare in children. They pose challenges for the treating surgeon in decision making with respect to diagnosis, surgical and post-surgical management. The management plan must be tailored to the nature and severity of trauma, patient profile, surgeon′s expertise and the resources available at surgeon′s disposal. We describe a pancreaticoduodenal injury in 3-year-old child with successful outcome and follow-up of a decade
"Euclid - Mapping the geometry of the dark Universe". Euclid assessment study report (SRE-2009-2).
No full textEuclid is a high-precision survey mission to map the geometry of the Dark Universe with demonstrated feasibility. Euclid’s Visible-NIR imaging and spectroscopy of the entire extragalactic sky will further
produce extensive legacy science to the boundaries of the visible universe
Characterization of the interaction of a TCR α chain variable domain with MHC II I-A molecules
No full textThe αβ TCR recognizes peptides bound to MHC molecules. In the present study, we analyzed the interaction of a soluble TCR α chain variable domain (V(α)4.2-J(α)40; abbreviated to V(α)4.2) with the MHC class II molecule I-A(u). V(α)4.2 bound specifically to I-A(u) expressed on the surface of a transfected thymoma cell line. Modifications in the amino acid residues located within the three complementarity-determining regions (CDRs) of the V(α) domain did not markedly affect this interaction. However, mutation of glutamic acid to alanine at position 69 of the fourth hypervariable region (HV4α) significantly increased the binding. Antibody inhibition studies suggested that the binding site was partly contributed by a region of the β chain of I-A(u). Furthermore, the binding of V(α)4.2 to the MHC molecule was dependent on the nature of the peptide bound in the groove. Soluble V(α)4.2 specifically inhibited the activation of TCR transfectants by I-A(u)-expressing cells pulsed with an N-terminal peptide of myelin basic protein. V(α)4.2 also bound to MHC class II-expressing spleen cell populations from mice of the H-2(u) and H-2(d) haplotypes. The binding of V(α)4.2 to I-A molecules might explain the immunoregulatory effects reported previously for TCR α chains. This V(α)4.2 interaction may also be relevant to models of antigen presentation involving the binding of intact proteins to MHC class II molecules followed by their processing to generate epitopes suitable for T cell recognition.</p
Unfavourable results in pollicisation
No full textPollicisation of the index finger is perhaps one of the most complex and most rewarding operations in hand and plastic surgery. It however has a steep learning curve and demands very high skill levels and experience. There are multiple pitfalls and each can result in an unfavourable result. In essence we need to: Shorten the Index, recreate the carpo metacarpal joint from the metacarpo phalangeal (MP) joint, rotate the digit by about 120° for pulp to pulp pinch, palmarly abduct by 40-50° to get a new first web gap, Shorten and readjust the tension of the extensors, re attach the intrinsics to form a thenar eminence capable of positioning the new thumb in various functional positions and finally close the flaps forming a new skin envelope. The author has performed over 75 pollicisations personally and has personal experience of some of the issues raised there. The steps mentioned therefore are an algorithm for helping the uninitiated into these choppy waters
New Photometry and Spectra of AB Doradus C: An Accurate Mass Determination of a Young Low-Mass Object with Theoretical Evolutionary Tracks
No full textWe present new photometric and spectroscopic measurements for the unique, young, low-mass evolutionary track calibrator AB Dor C. While the new Ks photometry is similar to that previously published in Close et al. (2005) the spectral type is found to be earlier. Based on new H and K IFS spectra of AB Dor C (Thatte et al. 2007; paper 1) we adopt a spectral type of M5.5+/-1.0 for AB Dor C. This is considerably earlier than the M8+/-1 estimated in Close et al. (2005) and Nielsen et al. (2005) yet is consistent with the M6+/-1 independently derived by Luhman and Potter (2005). However, the spectrum presented in paper 1 and analyzed here is a significant improvement over any previous spectrum of AB Dor C. We also present new astrometry for the system which further supports a 0.090+/-0.005 Msun mass for the system. Once armed with an accurate spectrum and Ks flux we find L=0.0021+/-0.0005 Lsun and Teff=2925{+170}{-145}K for AB Dor C. These values are consistent with a ~75 Myr 0.090+/-0.005 Msun object like AB Dor C according to the DUSTY evolutionary tracks (Chabrier et al. 2000). Hence masses can be estimated from the HR diagram with the DUSTY tracks for young low-mass objects like AB Dor C. However, we cautiously note that underestimates of the mass from the tracks can occur if one lacks a proper (continuum preserved) spectra or is relying on NIR fluxes alone
A role for the region encompassing the c'' strand of a TCR Vα domain in T cell activation events
No full textThe distinct strand topology of TCR Vα domains results in a flatter surface in the region encompassing the c' strand than the corresponding region in Ig V domains. In the current study a possible role for this region in T cell activation has been investigated by inserting a potential glycosylation site at Vα residue 82. This residue is in proximity to the c'' strand and distal to the putative interaction site for cognate peptide:MHC ligand. An additional N-linked carbohydrate at this position would create a protrusion on the Vα domain surface, and this may interfere with TCR aggregation and/or recruitment of signaling molecules. The modified TCR has been expressed in transfected T cells, and the phenotype following stimulation has been compared with that of cells expressing the wild-type TCR. The mutation has significant effects on activation-induced cell death and TCR internalization, but, unexpectedly, does not affect IL-2 secretion. Furthermore, analyses with tetrameric, peptide:MHC class II complexes suggest that the mutation decreases the ability of the TCR to aggregate into a configuration compatible with avid binding by these multivalent ligands.</p
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