24 research outputs found
Multipotent action of Rhizophora mucronata (red mangrove) as neuroprotective drug against Alzheimer's disease ? Evidence from preclinical studies
No full text
Treatment of multiple warts – efficacy of homologous autoimplantation therapy and comparison of homologous autoimplantion therapy and cryotherapy with liquid nitrogen
No full textINTRODUCTION:
Warts or verrucae are one of the common cutaneous viral
infections, caused by human papilloma virus. They are benign tumours which commonly involve the skin and other epithelial tissues1. Patients seek treatment for a variety of reasons including the unsightly appearance, the pain and the discomfort it causes. The ideal aim during treatment of warts should be to remove the wart without recurrence, avoid
mutilating procedures and to help the body’s immune system to deal with the infection better, producing lifelong immunity against the viral infection.
Treatment of warts is difficult though many modalities are
available, more so with multiple and recalcitrant warts. Warts may need differing treatments based on their type and site.
Cryotherapy with liquid nitrogen is a very commonly used
modality of treatment for warts and is a simple, safe and inexpensive office procedure. But it requires treatment of every individual lesion and this makes treatment of multiple warts by this technique, cumbersome.
Homologous autoimplantation is a simple and novel method of
treatment of warts which involves harvesting a bit of the wart tissue and implanting it subcutaneously. This, theoretically induces an immune response which leads to resolution of warts.
AIMS AND OBJECTIVES:
1. To determine the efficacy of cryotherapy with liquid nitrogen and homologous autoimplantation therapy in the treatment of multiple warts.
2. To evaluate the safety and adverse effects of the two modalities of therapy.
3. To monitor the recurrence of warts following each therapeutic modality.
MATERIALS AND METHODS:
TRIAL DESIGN:
O p e n labelled prospective study with the approval of ethical committee.
STUDY POPULATION:
Hundred patients with multiple warts diagnosed on clinical grounds, attending the dermatology out patient clinic of Madras Medical College, Chennai, between December 2011 and November 2012
INCLUSION CRITERIA:
1. Multiple warts > 5 in number.
2. Duration below 3 years.
3. Treatment free period of 4 weeks prior to joining this study.
EXCLUSION CRITERIA:
1. Warts other than verruca vulgaris and palmoplantar warts.
2. Pregnancy and lactation.
3. Children < 12 years of age.
4. Immunosuppressed patients.
5. H/O immunosuppressive drug intake.
6. H/O cold urticaria, cryoglobulinemia
7. Raynaud’s disease.
8. Collagen vascular diseases.
CONCLUSION:
1. The cure rate with homologous autoimplantation therapy for warts was significantly higher that the cure rate of cryotherapy with liquid nitrogen by the dipstick method. But the time taken for resolution was shorter by cryotherapy (Mean – 2.28 weeks) as compared to autoimplantation therapy (Mean – 6.46 weeks).
2. Complications were much higher in the cryotherapy group than the autoimplantation group. Both the procedures were safe and harmless as no severe complication was noted.
3. There was recurrence seen in the cryotherapy group whereas the autoimplantation group showed no recurrence, though the difference in the recurrence rate was not statistically significant
Safety assessment of methanolic extract of Terminalia chebula fruit, Terminalia arjuna bark and its bioactive constituent 7-methyl gallic acid: In vitro and in vivo studies
No full textMicropropagation and in vitro culture of Pyrethrum [Chrysanthemum cinerariifolium (Trev.) Vis.]
No full textPyrethrum (Chrysanthemum cinerariifolium (Trev.) Vis. = Tanacetum cineariaefolium (Trev.) Schultz-Bip.) is a perennial herbaceous plant belonging to the family Asteraceae, native to Albania and the area of former Yugoslavia. It is the only species in the genus Tanacetum having an agronomic importance, although the genus consists of several species producing similar types of bioactive metabolites. The species is grown in order to obtain the insecticidal compounds collectively termed pyrethrins, which are found primarily in the flower heads.
In this work we discuss the results found from a worldwide literature review about the micropropagation techniques followed on Pyrethrum, the in vitro culture conditions, and the ex vitro establishment trials under Mediterranean environmental conditions. Many technical problems concerning the propagation of the species seem to have been solved, and detailed protocols are available for an easy and fast propagation by seeds, vegetative splits, stem cuttings (rooted under mist or not), and tissue culture. The first attempts to introduce its cultivation into the semi-arid Mediterranean environments have brought to satisfactory results, and the species may be suggested as a valuable opportunity for the development strategies in new Mediterranean farming systems
Immunological effects of feeding different sources of vitamin E and seaweed in a sheep herd during the winter season
No full textIn winter fed organic raised sheep inadequate plasma vitamin E levels is common and therefore
supplementation is recommended. The objective of the present work was to test the supplementation
of natural vitamin E and seaweed meal on the immune status of ewes and their offspring.
Forty Norwegian White Sheep ewes were randomly allocated to three supplementation treatments:
natural vitamin E, synthetic vitamin E, seaweed meal, and control. The feeding experiment lasted
the entire indoor feeding period. Ewes and newborn lambs were vaccinated against different environmental
microorganisms and pathogens. Different immunological parameters were measured.
Supplementing the ewes with natural vitamin E had positive effect on immunity against Mycobacterium
bovis in lambs. Seaweed, on the other hand, had negative effect on the passive transfer of maternal
antibodies in lambs the first week after birth. The adaptive immunity was not affected by
seaweed supplementation
Prevalence and RIsk factors for Silent Myocardial ischemia (PRISM): A clinico observational study in patients of type 2 diabetes
No full textObjectives: To estimate the prevalence and to identify potential risk factors of silent myocardial ischemia in a cohort of patients with asymptomatic type 2 Diabetes (diabetes) for early detection of coronary risk by employing objective noninvasive clinical screening tools for Subclinical Atherosclerosis.
Methods: The study is a clinic-based observational study on 338 consecutive diabetes patients attending an urban health center from Eastern India. The response rate was 96.57% out of 350 eligible subjects, comprising 176 (52.1%) males and 162 (47.9%) females. Clinical, anthropometric, biochemical parameters were collected in all participants. Both tools, i.e., treadmill test (TMT) to identify subjects with silent myocardial ischemia, and carotid imaging to detect subclinical atherosclerosis by evaluating carotid intima-media thickness (CIMT), were assessed. Significant determinants were predicted by multivariable logistic regression.
Results: The study group was divided into a TMT negative (n = 260), and a TMT positive group (n = 78). These 78 TMT positive subjects (23.1%) were identified to have silent myocardial ischemia. The prevalence of silent myocardial ischemia was more common in males (28.4%) than in females (17.3%). The mean CIMT in our study group was 0.6741 ± 0.034 mm (males - 0.684 ± 0.034 mm and females - 0.663 ± 0.032 mm). Age ≥50 years, CIMT ≥0.70 mm, hypercholesterolemia, and hypertriglyceridemia were significant determinants for identifying asymptomatic diabetics at risk for silent myocardial ischemia.
Conclusion: Silent myocardial ischemia is highly prevalent at about one in four asymptomatic diabetic patients. An increased CIMT can be a surrogate marker of higher coronary risk amongst these asymptomatic diabetics
Evaluation of Gelidiella acerosa, the red algae inhabiting South Indian coastal area for antioxidant and metal chelating potential
No full textEvidence of ZIO positive Langerhans cell: a dendritic cell subset in normal and polypoid nasal mucosa
No full textNasal polyps are outgrowths of oedematous nasal mucosa of inflammatory origin. Langerhans cells (LCs) residing in the nasal mucosa are responsible for maintaining the immunological environment. This study aims to ascertain the distribution of zinc iodide osmium (ZIO) positive LCs in normal nasal mucosa, and to compare the same with that in polypoid mucosa. Normal nasal mucosa obtained from patients undergoing septoplasty (n=21) and polypoid mucosa (n=21) obtained from patients with sinonasal polyposis due to diffuse sinonasal inflammation or allergic fungal rhinosinusitis were processed for identification of LCs using the ZIO technique. The number of ZIO positive LCs were counted per unit area of lamina propria and statistically analysed. The ZIO positive LCs were seen in the epithelium, lamina propria and among the glands. Both dendritic and non-dendritic LCs were present. They were noted within the lymphatic aggregations in the lamina propria, and were also noted in and around the blood vessels. The ZIO positive LCs were present in both normal and polypoid nasal mucosa. The median number of ZIO positive LCs was 0 (range: 0-1) per mm2 and 12 (range: 0-44) per mm2 in the normal and polypoid groups, respectively. This difference was statistically significant (p=0.001). No significant difference was noted based on the aetiology of the polyps. This is the first report of the presence of ZIO positive LCs in the nasal mucosa. Their significantly higher number in nasal polyps suggests an immunological role in the presence of inflammation
Evidence of ZIO positive Langerhans cell: a dendritic cell subset in normal and polypoid nasal mucosa
No full textNasal polyps are outgrowths of oedematous nasal mucosa of inflammatory origin. Langerhans cells (LCs) residing in the nasal mucosa are responsible for maintaining the immunological environment. This study aims to ascertain the distribution of zinc iodide osmium (ZIO) positive LCs in normal nasal mucosa, and to compare the same with that in polypoid mucosa. Normal nasal mucosa obtained from patients undergoing septoplasty (n=21) and polypoid mucosa (n=21) obtained from patients with sinonasal polyposis due to diffuse sinonasal inflammation or allergic fungal rhinosinusitis were processed for identification of LCs using the ZIO technique. The number of ZIO positive LCs were counted per unit area of lamina propria and statistically analysed. The ZIO positive LCs were seen in the epithelium, lamina propria and among the glands. Both dendritic and non-dendritic LCs were present. They were noted within the lymphatic aggregations in the lamina propria, and were also noted in and around the blood vessels. The ZIO positive LCs were present in both normal and polypoid nasal mucosa. The median number of ZIO positive LCs was 0 (range: 0-1) per mm2 and 12 (range: 0-44) per mm2 in the normal and polypoid groups, respectively. This difference was statistically significant (p=0.001). No significant difference was noted based on the aetiology of the polyps. This is the first report of the presence of ZIO positive LCs in the nasal mucosa. Their significantly higher number in nasal polyps suggests an immunological role in the presence of inflammation
