1,720,998 research outputs found
Ameliorating effect of carnitine on liver mitochondria functions in ammonium intoxicated rats
No full textWe have studied some functions of mitochondria isolated from livers of rats previously treated with ammonium acetate or with this salt plus carnitine. The results reported here show that carnitine administration exerts a protective action against functional damage caused by ammonium acetate in the liver mitochondria of treated animal
Electrophoretic spermine transport and its effect on phosphate transport in liver mitochondria
No full textThe dependence of spermine transport on mitochondrial potential is evidenced by the close parallelism between mitochondrial potential changes, induced by the reversibile transition “state 4-state 3”, and spermine movements
Studies of the ligand-receptor interactions in the biological systems. Part II: polyamine binding sites in rat liver mitochondria
No full textEffect of acute exercise and L-carnitine administration on rat liver mitochondria
No full textThe present study investigated the effect of acute physical exercise and L-carnitine treatment on the respiratory functions of rat liver mitochondria. This work clearly demonstrates that physical exercise induces a significant increase in state 3 respiration, which is further enhanced by the concomitant L-carnitine administration
Spermine-mediated Casein Kinase II-uptake By Rat-liver Mitochondria
No full textSpermine, ubiquitous intracellular polyamine, is able to promote the transmembrane translocation of casein kinase CKII through the outer membrane of rat liver mitochondria and its binding to more internal mitochondrial structures. These findings suggest that spermine may play a critical role in regulating the subcellular distribution of casein kinase CKII
Transport and action of spermine in rat heart mitochondria
No full textAt concentrations of 0.5-1.0 mM, spermine fully prevents the fall of membrane potential induced in rat heart mitochondria either by aging at room tempetrature or by the addition of palmitoyl CoA. Spermine also prevents the inhibitory action of palmitoyl CoA on adenylate translocase activity. When added to heart mitochondria de-energized by the same damaging conditions (aging or addition of palmitoyl CoA) spermine restores both membrane potential (provided that ATP is also added) and the activity of adenylate translocase. A part of addded spermine is immediately bound to anionc sites on mitochondrial membranes, another part is slowly transported into heart mitochondria. Whereas binding is an energy independent process, transport is driven by the transmembrane potential. Spermine penetrates the mitochondrial matrix at significant rates only at high membrane potential, such as that produced either by phosphate transport or addition of nigericin
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