384 research outputs found
Assessing the stability of underground caves through iSUMM (innovative, straightforward, user-friendly, mechanically-based method)
No full textA huge number of sinkhole events has been recorded in different Italian urban areas, with an occurrence frequency largely increasing in the last decades, sometimes even causing loss of human lives. The main reason for such catastrophic events is the presence of man-made underground cavities, excavated within soft rocks, several decades ago and then abandoned, at shallow depths. Here, the possibility of interaction with overlying buildings and infrastructures and the corresponding sinkhole hazard is relatively high. In such contexts, the low mechanical properties of the soft rock formations where the cavities have been excavated, like those formed of calcarenites, which outcrop in large areas of Southern Italy, and their high susceptibility to weathering processes, represent one of the most important predisposing factors for instability. Therefore, assessing the stability of underground cavities is crucial for land management and planning purposes. The mechanically-based stability charts developed by Perrotti et al. (Int J Geomech 18(7):04018071, 2018) have proved to be a valid tool for preliminary stability assessment and, although allow to identify an eventual proneness of the cave to instability, they do not provide quantitative assessment about the safety margin itself. In that regard, this study intends to present the most recent outcomes obtained in the development of the methodology and is aimed at promoting an enhanced way for their application, so that the charts can become an operative tool for preliminary sinkhole hazard assessment in similar regions in the world
Stability charts based on the finite element method for underground cavities in soft carbonate rocks: validation through case-study applications
No full textThe stability of man-made underground cavities in soft rocks interacting with overlying structures and infrastructures represents a challenging problem to be faced. Based upon the results of a large number of parametric twodimensional (2-D) finite-element analyses of ideal cases of underground cavities, Accounting for the variability both cave geometrical features and rock mechanical properties, specific charts have been recently proposed in the literature to assess at a preliminary stage the stability of the cavities. The purpose of the present paper is to validate the efficacy of the stability charts through the application to several case studies of underground cavities, considering both quarries collapsed in the past and quarries still stable. The stability graphs proposed by Perrotti et al. (2018) can be useful to evaluate, in a preliminary way, a safety margin for cavities that have not reached failure and to detect indications of predisposition to local or general instability phenomena. Alternatively, for sinkholes that already occurred, the graphs may be useful in identifying the conditions that led to the collapse, highlighting the importance of some structural elements (as pillars and internal walls) on the overall stability of the quarry system
Sinkhole susceptibility assessment of underground caves in soft rocks by means of FEM-based charts.
No full textThe presence of man-made underground caves in soft carbonate rocks susceptible to degradation processes due to weathering nowadays induce high risk conditions in the Apulia region (Southern Italy) which is characterised by a huge number of caves spread in the territory. In recent years, several collapses affected some of these cavity systems, involving structures and roads located at the ground surface and, therefore, inducing high risk for human life and properties. In order to comply with this problem at the regional scale, Perrotti et al., 2018, have proposed specific charts aimed at assessing at a preliminary stage the stability conditions of a cave along with a safety margin with respect to the occurrence of failure. The charts have been defined upon the results of a large set of parametric two-dimensional finite-element analyses of ideal cases of underground cavities that account for the typical geometrical features of the caves and the range of mechanical properties of these rocks. The relationships obtained in terms of plots representing the ratio between the strength mobilized at failure and the vertical stress at the cavity roof against the ratio between cave width and roof thickness identify mechanically-based threshold envelopes for stability. In this paper, applications of the stability charts to case studies of man-made underground caves of soft carbonate rocks, either subjected to failure in the past or still stable, are discussed. In the first case the applications proposed show the role of specific structural elements, as pillars and walls, on the general stability of the examined quarry system, while in the second case an indication on the safety factor of the cave with respect to instability has been derived. Therefore, the proposed stability charts have been verified to provide a reliable method to assess in a preliminary way the stability of underground cavities in soft carbonate rocks, so that, for those situations where the safety margin results to be low, more detailed and sophisticated numerical models need to be developed
Neurodevelopmental genetic drivers of the human 22q11.2 region
Get PDFDespite substantial progress have been made to understand the wide spectrum of congenital anomalies and birth defects associated with 22q11.2 segmental aneuploidies, the highest comorbidity rate for neurodevelopmental disorders (NDDs) has been also recently showed in this cohort compared to any other genetic conditions. To further define, hence to experimentally confirm, the pivotal neurodevelopmental role of the 22q11.2 region we applied different approaches to identify those genes whose impairment may not only impinge on 22q11.2 rearrangements’ medical history as modifying factors, but that may also constitute per se NDDs’ driver-genes. Through a “genotype-first” approach we identified 8 genes (ARVCF, CLDN5, DGCR8, RANBP1, TRMT2A, MED15, AIFM3 and LZTR1) that, according to the enrichment criteria applied, can exert a downstream functional convergence upon those circuits involved in physiological neurodevelopment as well as in pathophysiological behaviors. By targeted resequencing two prioritized genes, ARVCF and LZTR1, we proved that: (i) their impairment can contribute to the genetic background toward variability of neurodevelopmental phenotypes seen in individuals carrying 22q11.2 CNVs; (ii) these genes may constitute per se NDD driver. Hence, in order to identify novel NDD genes potentially sensitive to dosage imbalance within the distal 22q11.2 chromosomal region, we developed a “phenotype-first” approach building the distal 22q11.2 CNVs “co-morbidity” map that allowed us: (i) to elucidate that the 22q11.2 distal deletion and duplication events respectively clinically define a syndromic versus a non-syndromic neurodevelopmental disorder; (ii) to identify two small NDD genomic regions of interest harbored within. Deeply investigating two rearranged 22q11.22q11.23 carriers’ families, whose segmental aneuploidies were retrieved fully incorporating one of our predicted pathogenic frames, we functionally showed that the RAB36 gene may play a role in NDD pathogenesis acting in a dosage-dependent manner. Overall, these research project’s results added new insights on the elucidation of 22q11.2-related neurobehavioral outcomes as well as of NDDs’ neuroscience physiopathology, widening the scope on those dynamics that constantly shape and re-shape the human brain
J. Le Brun. Le Pur Amour de Platon à Lacan
No full textPerrotti Gabriele. J. Le Brun. Le Pur Amour de Platon à Lacan. In: Revue de l'histoire des religions, tome 221, n°3, 2004. pp. 363-368
À la Cour des Bourbons de Naples : le «Dessert per 60 coverti»
No full textCaròla-Perrotti Angela. À la Cour des Bourbons de Naples : le «Dessert per 60 coverti». In: Sèvres. Revue de la Société des Amis du musée national de Céramique, n°26, 2017. pp. 54-73
R code used to map the semantic field of the term "urban metabolism" through four semantic networks
No full text<p>This file contains the R code used to analyze textual data and metadata collected within the framework of a research project on the concept of urban metabolism headed by Professor Daniela Perrotti and supported by the Belgian Fund for Scientific Reseach F.R.S-FNRS under Grant n° MIS-F.4536.22. </p>
R code used to map the semantic field of the term "urban metabolism" through four semantic networks
No full text<p>This file contains the R code used to analyze textual data and metadata collected within the framework of a research project on the concept of urban metabolism headed by Professor Daniela Perrotti and supported by the Belgian Fund for Scientific Reseach F.R.S-FNRS under Grant n° MIS-F.4536.22. </p>
A visão crítica da literatura infantil na década de 1980 em O texto sedutor na literatura infantil, de Edmir Perrotti
Get PDFApplying the analytical method proposed by Maria do Rosário Longo Mortatti, it is presented an study of the textual configuration of the book O texto sedutor na literature infantile ,from Edmir Perrotti, allowing to understand: a) author´s concepts about the children's literature; b) thematic contents and structural-formal textual options; c) the speech’s determination according to its relationship with the author's place in society, the historical moment; the needs and goals established to reach the reader. This study also presents Perrotti´s thoughts about several other Brazilian researchers of children's literatureUtilizando o método analítico proposto por Maria do Rosário Longo Mortatti, desenvolve-se análise da configuração textual da obra O texto sedutor na literatura infantil, de Edmir Perrotti. O método permite compreender:a) a visão do autor sobre a literatura infantil;b) as opções temático-conteudísticas e estruturais-formais do texto;c) a determinação do discurso em função das relações do autor com seu lugar social, momento histórico, necessidades e propósitos estabelecidos com o leitor,circulação e utilização esperadas.Apresenta-se, ainda, o pensamento de Perrotti sobre outros pesquisadores brasileiros da literatura infantil.  
"Runninghami : origami bianco nelle pieghe di un paesaggio autostradale", in Contemporaneamente - ACHROME, n. 5 - dicembre 2009
No full textArticolo sul concept design "Runninghami", progetto di una barriera autostradale anti-rumore, nell’ambito del programma francese “Autoroute design” della Direction Départementale de l’Équipement della Loira.
Il progetto, elaborato in seno ad un’equipe multidisciplinare franco-svizzera di architetti, ingegneri dei trasporti, urbanisti, designer della luce e del suono e diretta dell’architetto e geografo
Pascal Amphoux, nasce da una riflessione sulla possibile leggerezza visuale e materiale di un oggetto normalmente pesante e visivamente ingombrante
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