839 research outputs found
James McConkey Interview
No full textTom Kenny of WLEX-TV Lexington, Kentucky interviews James McConkey, author of Rowan\u27s Progress discussing the exploits of Dr. C. Louise Caudill of Morehead, Kentucky in 1992
A Conversation with Jim McConkey
No full textJames McConkey, is Goldwin Smith Professor of English Literature Emeritus at Cornell University. Known for his meditative nonfiction narratives, James McConkey began teaching at Cornell in 1956, as an assistant professor in the English department. He wrote fiction until the early 1960s, and retired in 1992 as Goldwin Smith Professor of English Literature Emeritus. McConkey is the author or editor of 14 books, including Court of Memory, Stories from My Life with the Other Animals, To a Distant Island, and The Anatomy of Memory. His research and teaching interests are Creative writing (poetry and fiction), Modern literature and prose, Modern fiction, particularly British.1_ew9i5nu
F.C. Koziol, Jim McConkey & Gordon Harmston
No full textPhoto shows F.C. Koziol, Jim McConkey & Gordon Harmsto
Jim McConkey skiing at Alta, early 1960s.
No full textPhoto shows Jim McConkey skiing at Alta, early 1960
Validation of co-oximetry for methemoglobin measurement in rainbow trout and the investigation of benzocaine as a cause of methemoglobin in salmonids
No full textAbstract not available.Source: Masters Abstracts International, Volume: 50-04, page: 2294.Advisers: Sandra McConkey; Dave Speare
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
No full textThe majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets. Our strategy uses DNA fusion vaccines to activate high levels of peptide-specific CTL. Key foreign sequences from tetanus toxin activate tolerance-breaking CD4+ T cell help. Candidate MHC class Ibinding tumor peptide sequences are fused to the C terminus for optimal processing and presentation. To model performance against a leukemia-associated antigen in a tolerized setting, we constructed a fusion vaccine encoding an immunodominant CTL epitopederived from Friend murine leukemia virus gag protein (FMuLVgag) and vaccinated tolerant FMuLVgag-transgenic (gag-Tg) mice. Vaccination with the construct induced epitopespecificIFN-c-producing CD8+ T cells in normal and gag-Tg mice. The frequency and avidity of activated cells were reduced in gag-Tg mice, and no autoimmune injury resulted. However, these CD8+ T cells did exhibit gag-specific cytotoxicity in vitro and in vivo. Also, epitope-specific CTL killed FBL-3 leukemia cells expressing endogenous FMuLVgag antigen and protected against leukemia challenge in vivo. These results demonstrate a simple strategy to engage anti-microbial T cell help to activate epitope-specific polyclonal CD8+ T cell responses from a residual tolerized repertoire
Electron impact excitation studies of unstable atomic species.
No full textThe polarization of Balmer-alpha radiation excited in collisions of electrons with atomic hydrogen is presented for an electron energy range from threshold to 1000 eV. Measurements are in good agreement with calculations carried out using either convergent-close-coupling or R-matrix with pseudo-states approaches. Cascade is demonstrated to have a significant effect. Balmer-alpha excitation function data are also presented. A previous measurement of the polarization of Balmer-alpha following dissociative excitation of H2 by electrons is confirmed and extended. The electron impact excitation spectrum of atomic and molecular nitrogen in the VUV range (800 A--1800 A) is presented. The excitation functions of the 1135 A and the 1200 A transitions are obtained. About 5% of nitrogen molecules are dissociated using a microwave discharge source and a mixture of 95% helium and 5% nitrogen gases. Other lines proved to have too small an emission cross section for the electron impact excitation process on atomic nitrogen. Thus the 1243 A, 1494 A, 1745 A N lines and the 1085 A N+ line could not be studied using the small dissociation fractions obtained in the present work. Electron impact excitation of fluorine and sulfur atoms is presented. The spectrum of Sulfur Hexafluoride (SF6) in the VUV range from 800 A--1700 A is recorded. A 70% dissociation fraction was obtained using the microwave discharge unit with SF6 and He targets. The absolute emission cross section for the 807 A fluorine transition is found to be 2.21 +/- 1.20 x 10-19 cm 2 at 200 eV electron energy. As for sulfur, the absolute emission cross section for the 1474 A transition is 2.46 +/- 1.38 x 10-19 cm2 at 95 eV and for the 1667 A transition is 1.87 +/- 1.31 x 10-19 cm 2 at 85 eV. Source: Dissertation Abstracts International, Volume: 64-10, Section: B, page: 4994. Adviser: J. W. McConkey. Thesis (Ph.D.)--University of Windsor (Canada), 2003
Production and detection of metastable atomic oxygen.
No full textThe metastable species O(\sp1S) has been observed following the dissociation of O\sb2, N\sb2O, and CO\sb2 molecules by pulsed electron impact. A crossed beam apparatus was used to obtain time-of-flight spectra of the fragments. A novel detector which consists of a layer of freshly deposited Xe was employed. O(\sp1S) atoms impinging on the surface quickly (1s) form XeO* excimers which rapidly decay (100ns) producing easily detected photons. In the case of O\sb2 and N\sb2O present results indicate that this method is sensitive solely to O(\sp1S) with high quantum efficiency. Other ground state or metastable fragments (such as O(\sp3P), O(\sp1D), O(\sp5S\sp{\rm o}), or N\sb2(A\sp3\Sigma\sbsp{\rm u}{+})) have not been detected. In the case of CO\sb2, the Xe layer is sensitive to O(\sp1S) and the metastable CO(a\sp3\Pi). Low resolution optical spectra of the emissions which follow the arrival of O(\sp1S) at the Xe layer reveal bands at 375, 550, and 725 nm; while CO(a\sp3\Pi) fragments impinging on the layer produce emissions below 350 nm. Time-of-flight and released kinetic energy spectra for all target gases at various electron impact energies are presented together with excitation functions from threshold to 1000 eV. These have been made absolute using a Bethe-Born calibration technique for O(\sp1S) from N\sb2O. For O(\sp1S) from O\sb2 and CO\sb2, the data are calibrated relative to N\sb2O. Maximum cross sections for O(\sp1S) production are 2.25 10\sp{-17} cm\sp2 at 45 eV, 2.08 10\sp{-18} cm\sp2 at 80 eV, and 1.68 10\sp{-17} cm\sp2 at 50 eV, for N\sb2O, O\sb2, and CO\sb2 targets respectively. The cross section for CO(a\sp3\Pi) production from dissociative excitation of CO\sb2 has a maximum of 2.8 10\sp{-16} cm\sp2 at 25 eV.Dept. of Physics. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis1993 .L435. Source: Dissertation Abstracts International, Volume: 55-05, Section: B, page: 1893. Adviser: John William McConkey. Thesis (Ph.D.)--University of Windsor (Canada), 1993
Laser-induced fluorescence measurements on electron-impact excited molecules.
No full textAn electron-impact excited jet-cooled molecular beam was probed by a tunable dye laser system allowing elucidation of the electron-impact ionization and dissociation processes. This technique has been applied to the study of the rotational ground state and excited state populations of electron-impact excited N\sb2\sp{+}. Following electron-impact dissociation of acetonitrile, water and methanol similar measurements have been performed on the rotational populations of CN(X) and OH(X). We also present results for the absolute cross section for the electron-impact formation of CN(X) from CH\sb3CN. Measurements have also been performed on the relative cross section for the electron impact dissociation of OH(X) from H\sb2O and CH\sb3OH. We have demonstrated the feasibility of the technique and discuss several possible future avenues of research.Dept. of Physics. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis1991 .D377. Source: Dissertation Abstracts International, Volume: 53-01, Section: B, page: 0352. Chairman: J. W. McConkey. Thesis (Ph.D.)--University of Windsor (Canada), 1990
- …
