162 research outputs found
cis-Bromido(n-butylamine-κN)bis(ethene-1,2-diamine-κ2N,N′)cobalt(III) dibromide
No full textIn the title compound, [CoBr(C2H8N2)2(C4H11N)]Br2, the cobalt(III) ion has a distorted octahedral coordination environment and is surrounded by four N atoms in the equatorial plane made up of three N atoms from the two ethylenediamine ligands and the remaining N from the n-butyl substituent, with the other N atom from the ethylenediamine ligand and the Br atom occupying the axial positions. In the crystal, the complex cation and the two counter-anions are linked via N—H...Br and C—H...Br hydrogen bonds, forming a three-dimensional network. The crystal studied was refined as a two-component inversion twin
<i>cis</i>-Bromidobis(1,2-diaminoethane-κ<sup>2</sup> <i>N</i>,<i>N</i>′)(ethylamine-κ<i>N</i>)cobalt(III) dibromide
No full textIn the title complex, [CoBr(C2H7N)(C2H8N2)2]Br2, the CoIII centre has a distorted octahedral coordination environment, and is surrounded by four N atoms in the equatorial plane, with an additional N atom and the Br atom occupying the axial positions. The complex is isostructural with the Cl compound for which the X-ray structure has also been reported [Anbalagan, Mahalakshmi & Ganeshraja (2011). J. Mol. Struct. 1005, 45–52]. In the crystal, the complex cation and the two counter-anions are linked via N—H...Br hydrogen bonds, forming a three-dimensional network.</jats:p
Topological indices for the iterations of Sierpiński rhombus and Koch snowflake
No full textIn fractal geometry, the study of Sierpiński rhombus and Koch snowflake is one of the important and interesting research topics. Sierpiński rhombus is a planar fractal which is created using a related sequence of graphs named , where is the Sierpinski graph. Same as Sierpiński, Koch snowflake is also created using a sequence of graphs named , where is the Koch snowflake graph. We can efficiently analyze their fractal structures by studying the topological indices for the graphs and . In this paper, the topological indices for and are calculated and compared with the fractal dimension for a sequence of graphs
DEVELOPMENT OF FAST-DISSOLVING TABLETS OF AMLODIPINE BESYLATE BY SOLID DISPERSION TECHNOLOGY USING POLOXAMER 407 AND POLOXAMER 188
No full textObjective: Amlodipine besylate is a calcium channel blocker used in the treatment of hypertension which is practically insoluble in water. The present study aims to design oral fast-release tablets of amlodipine besylate and to optimize the dissolution of the drug by altering the carrier concentration.Materials and Methods: Poloxamer 407 (P407) and poloxamer 188 (P188) were selected as carriers for the preparation of solid dispersion (SD) by the solvent evaporation method with different drug-polymer ratios. The prepared SDs were evaluated for the physical state, drug:carrier interactions by X-ray diffraction (XRD), infrared spectroscopy, differential scanning calorimetry, and scanning electron microscopy.Results: From the dissolution studies, it is confirmed that all SDs showed increased dissolution rate when compared to pure amlodipine besylate. Among the two polymers used, P407 was found to be better than P188 in enhancing dissolution efficiency. The tablets were prepared using SD of amlodipine besylate containing P407 as a carrier. The results showed that P407 SD-based tablets gave a significantly higher release of amlodipine besylate when compared with control tablets. The infrared spectral studies showed that there was no significant interaction between amlodipine besylate and its formulation with different polymers used in the preparation of SDs. XRD studies revealed that the degree of crystallinity of amlodipine besylate reduced when the concentration of carriers increased, which reveals that the drug is in amorphous nature.Conclusion: The combination of SD technology and using superdisintegrants in the formulation is a promising approach for preparing efficient, fast-dissolving tablet of poorly water-soluble drugs, viz., amlodipine besylate
DEVELOPMENT OF FAST-DISSOLVING TABLETS OF AMLODIPINE BESYLATE BY SOLID DISPERSION TECHNOLOGY USING POLOXAMER 407 AND POLOXAMER 188
No full textObjective: Amlodipine besylate is a calcium channel blocker used in the treatment of hypertension which is practically insoluble in water. The present study aims to design oral fast-release tablets of amlodipine besylate and to optimize the dissolution of the drug by altering the carrier concentration.Materials and Methods: Poloxamer 407 (P407) and poloxamer 188 (P188) were selected as carriers for the preparation of solid dispersion (SD) by the solvent evaporation method with different drug-polymer ratios. The prepared SDs were evaluated for the physical state, drug:carrier interactions by X-ray diffraction (XRD), infrared spectroscopy, differential scanning calorimetry, and scanning electron microscopy.Results: From the dissolution studies, it is confirmed that all SDs showed increased dissolution rate when compared to pure amlodipine besylate. Among the two polymers used, P407 was found to be better than P188 in enhancing dissolution efficiency. The tablets were prepared using SD of amlodipine besylate containing P407 as a carrier. The results showed that P407 SD-based tablets gave a significantly higher release of amlodipine besylate when compared with control tablets. The infrared spectral studies showed that there was no significant interaction between amlodipine besylate and its formulation with different polymers used in the preparation of SDs. XRD studies revealed that the degree of crystallinity of amlodipine besylate reduced when the concentration of carriers increased, which reveals that the drug is in amorphous nature.Conclusion: The combination of SD technology and using superdisintegrants in the formulation is a promising approach for preparing efficient, fast-dissolving tablet of poorly water-soluble drugs, viz., amlodipine besylate.</jats:p
Modelling in-plane behaviour of masonry shear walls through a predefined crack pattern at macro level
No full textThis thesis is a study towards in-plane behaviour of masonry shear walls modelled through a predefined crack pattern at macro level. The Semi-Lumped method, proposed by Messali (2015), is analysed in detail to confirm the consequences of the SLM assumptions. This is achieved via literature and numerical validations. The final part of the thesis contains a pilot study towards a combined procedure of the Semi-Lumped Method and the Sequentially linear analysis
Comparative Evaluation of Intermediate Irrigating Agents in Prevention of Precipitate Formed by Interaction of Sodium Hypochlorite and Chlorhexidine: An In Vitro study
No full textAIM OF THE STUDY:
The aim of this study is to prevent the formation of precipitate due to combined use of sodium hypochlorite and chlorhexidine by using two different antioxidant solutions, 6.25% sodium metabisulfite and 10% Gallic acid as intermediate flush and to compare the efficacy of both these solutions.
MATERIALS AND METHODS:
Sixty single rooted maxillary central incisors were used. The samples were divided into three groups (n=20), based on the intermediate irrigant used. Group 1- 5.25% Sodium hypochlorite irrigation + 2% Chlorhexidine (without intermediate flush). Group 2- 5.25% Sodium hypochlorite irrigation + 6.25% sodium metabisulfite irrigation + 2% Chlorhexidine. Group 3- 5.25% Sodium hypochlorite irrigation + 10% Gallic acid irrigation + 2% Chlorhexidine. The samples were split into 2 equal halves, studied under stereomicroscope and scored by the criteria given by Arslan [et al.].
RESULTS: Statistical analysis reveals overall intergroup comparison results were statistically significant (p< 0.05). Group 2 showed better performance than Group 1 and Group 3. Group 3 showed better performance than Group 1.
CONCLUSION:
6.25% Sodium metabisulfite and 10% Gallic acid had a positive effect on reducing the precipitate formation but not completely. 6.25% sodium metabisulfite showed better performance in reducing the precipitate when compared to 10% Gallic acid with statistical significance (p< 0.004)
Diaquadichloridobis(pyridine-&#954;N)manganese(II)
No full textThe molecular title compound, [MnCl2(C5H5N)2(H2O)2], lies about an inversion centre. The MnII atom is in an all-trans octahedral environment defined by two water molecules, two chloride anions and two pyridine ligands. An intermolecular hydrogen-bonding interaction between a water molecule and a chloride anion bonded to an adjacent MnII atom generates an eight-membered ring. The crystal packing exhibits two intermolecular &#960;&#8211;&#960; stacking interactions between the aromatic rings, with centroid&#8211;centroid distances of 3.485&#8197;(12) and 3.532&#8197;(12)&#8197;&#197;
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