1,310 research outputs found
Cahiers Octave Mirbeau, n°15, mars 2008. Numéro illustré de 135 photos, dessins, reproductions de toiles, couvertures de livres
No full textLair Samuel. Cahiers Octave Mirbeau, n°15, mars 2008. Numéro illustré de 135 photos, dessins, reproductions de toiles, couvertures de livres. In: Cahiers Edmond et Jules de Goncourt n°15, 2008. Les Goncourt moralistes. p. 229
The soluble leukocyte-associated Ig-like receptor (LAIR)-2 antagonizes the collagen/LAIR-1 inhibitory immune interaction
No full textLeukocyte-associated Ig-like receptor (LAIR)-1 is a collagen-receptor that inhibits immune cell function upon collagen binding. Next to LAIR-1, the human genome encodes LAIR-2, a putative soluble homolog. In this study we show, for the first time, that the LAIR-2 gene is broadly transcribed in human PBMC, mirroring the expression profile of LAIR-1. LAIR-2 protein is expressed as a soluble receptor exhibiting high affinity for various collagen molecules to which it binds in a hydroxyproline-dependent manner. In vitro stimulation of PBMC induces secretion of LAIR-2. We detect high amounts of LAIR-2 in urine of pregnant women, indicating that the soluble receptor is indeed produced in vivo and can be cleared from the body via urine. Furthermore, LAIR-2 levels are increased in synovial fluid of patients with rheumatoid arthritis as compared with osteoarthritis patients. We hypothesize that soluble LAIR-2 may function as a natural competitor for LAIR-1, thereby regulating its inhibitory potential. Indeed, LAIR-2 prevents binding of human LAIR-1 to collagens and LAIR-1 cross-linking in vitro, suggesting that the protein has an immunoregulatory function in vivo. Hence, we reveal a novel mechanism of immune regulation by a soluble LAIR receptor regulating the inhibitory potential of the membrane-bound LAIR-1 via competition for ligands
Lettre au sujet du mot ternagus
No full textLair Jules. Lettre au sujet du mot ternagus. In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 50ᵉ année, N. 6, 1906. pp. 386-387
La captivité de Pouqueville en Morée
No full textLair Jules. La captivité de Pouqueville en Morée. In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 46ᵉ année, N. 6, 1902. pp. 648-664
Pelecocera garrigae Lair & Ropars & Skevington & Kelso & Geslin & Minssieux & Nève 2022, sp. nov.
No full text<i>Pelecocera garrigae</i> Lair & Nève sp. nov. <p>Figs 1, 2, 7D, 8B, 9B, 10B</p> <p> <b>Type material</b>. <b>HOLOTYPE:</b> FRANCE: Pyrénées-Orientales: Sournia, Chemin de Roquebert, 42.7250°N 2.4660°E, alt. 480 m, 1 ♂ 17 April 2019 (X. Lair). Holotype deposited in the MNHN, specimen ED11396. <b>PARATYPES:</b> FRANCE, Bouches-du-Rhône: Marseilles, National Park of Calanques, La Panouse, 43.2564°N 5.4401°E, alt. 160 m, 1 ♂, 2 April 2017, IMBE 1001 and 1 ♀, 5 April 2018 (L. Ropars), paratype deposited in the MNHN, specimen ED11397; National Park of Calanques, La Gardiole, 43.2406°N 5.4781°E, alt. 203 m, 1 ♀, 3 May 2017, IMBE 1002; 1 ♀ 7 May 2018 (L. Ropars), CNC 1619206; Pyrénées-Orientales: 1 ♀, Sournia, chemin de Roquebert, 42.7250°N 2.4660°E, alt. 480 m, 24 April 2013 (X. Lair), this specimen was mentioned as <i>P. lusitanica</i> by Speight <i>et al</i>. (2013) and in Lair <i>et al</i>. (2021), XL01001; 1 ♀, 3 May 2018, (X. Lair), XL01002; 3 ♂, 17 April 2019 (X. Lair & C. Kassebeer), XL01003-01005; 1 ♂, 25 April 2020 (X. Lair), XL01006; 1 ♂ and 1 ♀, 28 April 2020, (X. Lair & E. Lecointe), XL01007-01008; 1 ♀, 4 May 2020 (A. Parret), XL01009; Alpes-de-Haute-Provence: 1 ♂, Saint-Michel l’Observatoire, 43,9300°N 5.7189°E, alt. 650 m, Malaise trap, 19-26 May 2010 (J.P. Orts & G. Nève), GN00524.</p> <p> <b>Additional examined material:</b> <b>SPAIN,</b> Malaga: ♀, Istan, 500 – 600m [ca. 36.5828°N 4.9494°W], 5 April 1972 (leg V. S. van der Goot & J.A.W. Lucas), NBC (mentioned as <i>Pelecocera</i> (<i>Chamaesyrphus</i>) Lair & Nève spec. nov in van Eck & Mengual 2021). <b>FRANCE,</b> Vaucluse: ♀, Caromb, Lac du Paty [ca. 44.1322° N 5.1136° E], 30 May 1995 (leg. Merz & Eggenberger), det. G. Pétremand 2020, MHNG.</p> <p> <b>Diagnosis</b>. <i>Pelecocera garrigae</i> <b>sp. nov.</b> is readily identified as belonging to the <i>Chamaesyrphus</i> subgenus due to the hair-like arista located dorsally on the basoflagellomere, and the anterior anepisternum with some white pile anterodorsally. In <i>P. garrigae</i>, the face protrudes forward and is entirely black with a shiny median stripe and mouth edge; the face sides are strongly pollinose, appearing light grey. The parafaces along the eyes are wide, reminiscent of <i>Cheilosia</i> Meigen, 1822. The lunule is slightly shiny and not pollinose. The frons is punctuate and not pollinose.</p> <p>The abdominal pattern is variable, either entirely black, or with pairs of lateral reddish-brown spots of varying size on tergites 3 to 5 (females), or 4 to 5 (males), or only on tergite 5 (females).</p> <p> <b>Description</b>. <b> MALE. <i>Measurements</i></b> . total body length (without antennae): 4.8 mm; wing length: 3.6 mm (holotype). Total body length: 4.8−6.4 mm; wing length: 3.6-4.7 mm (n = 3). <i>Head</i>. Antenna black, basoflagellomere with small ventral posterior orange spot. Arista black, bare, inserted dorsaly before the apex (from the middle to the three quarters of the ridge). Face: protrudes forward, entirely black and strongly pollinose, appearing whitish, except shiny mouth edge. Paraface narrower than in females. Frons: punctate and hardly polished, delimited by a curved transverse line (ridge) between the two eyes: the distance between the anterior ocellus and the ridge is 2 to 3 times the diameter of the anterior ocellus. Lunule: black, slightly shiny. Eyes bare. <i>Thorax</i>. Mesoscutum and scutellum shiny black, finely punctuate. covered with semi erected short white pile. Postpronotum and notopleuron pollinose. Scutellum shiny black. Pleura black, entirely pollinose. Anterior anepisternum with 3 or 4 white pile. One black seta on posterior anepisternum, postero-dorsally. Legs: Mainly black, with yellow trochanters. Covered with short white hairs. Femora 1-3 black, narrowly yellow at basal and apical ends. Tibiae 1-2 black, with third to half basal yellow bases and apex narrowly yellow. Tibia 3 black with yellow knees. Tarsi 1 and 2 yellowish to entirely black. Tarsus 3 black. Wing: Entirely covered with microtrichia. Upper outer cross-vein M1 strongly sloping. Stigma pale yellow. Alula: narrow, entirely covered with microtrichia. <i>Abdomen</i>. Narrow, with parallel edges. Tergites entirely black or with badly defined red brown lateral spots on tergites 3 and 4. Pregenital segment with white pile. Sternites: lustrous black, slightly pollinose, densely punctuated. <i>Genitalia</i>. The surstyli are symmetrical. Viewed laterally, their shape is subtriangular with a blunt apex covered with whitish pile. The cerci are semicircular, with long whitish pile. The hypandrium is elongate, subcylindrical, with a black cap at its apex and a bifid appendix ventrally.</p> <p> <b>FEMALE.</b> Very similar to males. <b>Measurements:</b> Total length (without antennae): 5.1 to 8.0 mm, wing length 4.4 to 6.5 mm (n=4). <b>Head:</b> Antenna black, basoflagellomere orange ventrally, with black upper ridge, the face protrudes forward and is entirely black, with a shiny mouth edge and a black shiny median stripe, the lateral face is pollinose, appearing light grey. The paraface are wider than in the male, reminiscent of <i>Cheilosia</i>. The anterior half of the frons is punctate and hardly polished, without any transverse pollinose band above the lunule unlike all other <i>Pelecocera</i> species. The lunule is dark brown or black, slightly shiny. <b>Abdomen:</b> The tergites are completely black, or with pairs of reddish-brown lateral spots on tergites 3 to 5, or only on tergite 5.</p> <p> <b>Etymology</b>. From the French noun “garrigue” (Bigot & Picard 1989), describing the Mediterranean scrubland on limestone where the species was found.</p> <p> <b>Distribution</b>. This species is known only from the locations mentioned above, in the French administrative departments of Pyrénées-Orientales, Bouches-du-Rhône, Alpes-de-Haute-Provence and Vaucluse (Fig. 3). In the Parc National des Calanques it has been found at localities up to 5.5 km apart. The species is probably still to be found in other limestone areas of Mediterranean France. The specimen from the Spanish province of Malaga indicates that the species is also be present in Spain.</p>Published as part of <i>Lair, Xavier, Ropars, Lise, Skevington, Jeffrey H., Kelso, Scott, Geslin, Benoît, Minssieux, Elise & Nève, Gabriel, 2022, Revision of the genus Pelecocera Meigen, 1822 (Diptera: Syrphidae) from France taxonomy, ecology and distribution, pp. 1-24 in Zootaxa 5141 (1)</i> on pages 8-10, DOI: 10.11646/zootaxa.5141.1.1, <a href="http://zenodo.org/record/6577662">http://zenodo.org/record/6577662</a>
Note de M. Brutails sur l'église de Saint-Orens de La Reulle, vers Saint-Savin (Hautes-Pyrénées)
No full textLair Jules. Note de M. Brutails sur l'église de Saint-Orens de La Reulle, vers Saint-Savin (Hautes-Pyrénées). In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 50ᵉ année, N. 5, 1906. pp. 327-328
Un formulaire normand de la fin du XIIIe siècle
No full textLair Jules. Un formulaire normand de la fin du XIIIe siècle. In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 48ᵉ année, N. 4, 1904. pp. 449-450
Identification de la localité normande nommée Rottemasse dans certains documents anglais de 1346 avec Barfleur (Cotentin)
No full textLair Jules. Identification de la localité normande nommée Rottemasse dans certains documents anglais de 1346 avec Barfleur (Cotentin). In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 48ᵉ année, N. 5, 1904. pp. 485-486
Lair (Maurice), Jaurès et l'Allemagne, 1935
No full textBourgin Georges. Lair (Maurice), Jaurès et l'Allemagne, 1935. In: Revue d'histoire moderne, tome 11 N°22,1936. pp. 191-192
Rapid and Highly Stable Membrane Reconstitution by LAiR Enables the Study of Physiological Integral Membrane Protein Functions
No full textFunctional reintegration into lipid environments represents a major challenge for in vitro investigation of integral membrane proteins (IMPs). Here, we report a new approach, termed LMNG Auto-insertion Reintegration (LAiR), for reintegration of IMPs into lipid bilayers within minutes. The resulting proteoliposomes displayed an unprecedented capability to maintain proton gradients and long-term stability. LAiR allowed for monitoring catalysis of a membrane-bound, physiologically relevant polyisoprenoid quinone substrate by Escherichia coli cytochromes bo3 (cbo3) and bd (cbd) under control of the proton motive force. LAiR also facilitated bulk-phase detection and physiological assessment of the “proton leak” in cbo3, a controversial catalytic state that previously was only approachable at the single-molecule level. LAiR maintained the multisubunit integrity and higher-order oligomeric states of the delicate mammalian F-ATP synthase. Given that LAiR can be applied to both liposomes and planar membrane bilayers and is compatible with IMPs and lipids from prokaryotic and eukaryotic sources, we anticipate LAiR to be applied broadly across basic research, pharmaceutical applications, and biotechnology.</p
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