473 research outputs found
Analyse de facteurs héréditaires et de milieu déterminant la réussite scolaire par l'étude de jumeaux élevés ensemble
No full textHusen Torsten. Analyse de facteurs héréditaires et de milieu déterminant la réussite scolaire par l'étude de jumeaux élevés ensemble. In: Bulletin de psychologie, tome 20 n°257, 1967. pp. 772-781
Husen Torsten — Origine sociale et éducation. Perspectives des recherches sur l'égalité devant l'éducation
No full textB H. Husen Torsten — Origine sociale et éducation. Perspectives des recherches sur l'égalité devant l'éducation. In: Population, 29ᵉ année, n°2, 1974. pp. 370-371
Van Husen D. dir. (2000) - Klimaentwicklung im Riss/Würm Interglacial (Eem) und Frühwürm in den Ostalpen
No full textCampy Michel. Van Husen D. dir. (2000) - Klimaentwicklung im Riss/Würm Interglacial (Eem) und Frühwürm in den Ostalpen. In: Bulletin de la Société préhistorique française, tome 99, n°2, 2002. p. 391
Dunkin (M.E.), De Landsheere (G.L.) éd. — Articles sur l'activité et la formation des enseignants in Husen (T.), Postlewhaite (N.) éd. — The International Encyclopedia of Education : Research and studies, 1985
No full textBourdoncle Raymond. Dunkin (M.E.), De Landsheere (G.L.) éd. — Articles sur l'activité et la formation des enseignants in Husen (T.), Postlewhaite (N.) éd. — The International Encyclopedia of Education : Research and studies, 1985. In: Recherche & Formation, N°1, 1987. Les professions de l'éducation : recherches et pratiques en formation. pp. 127-129
Differential expression of 17beta-hydroxysteroid dehydrogenases types 2 and 4 in human endometrial epithelial cell lines
No full textIn the endometrium two enzymes are known to convert estradiol to its inactive metabolite estrone: microsomal 17beta-hydroxysteroid dehydrogenase type 2 (17beta-HSD2) and peroxisomal 17beta-HSD4. In order to elucidate the particular function of each of these two different enzymes, the human endometrial epithelial cell lines HEC-1-A and RL95-2 were examined with respect to the expression of 17betaHSD isozymes. They were compared with human endometrium in vivo. Non-radioactive in situ hybridization revealed both enzymes in glandular epithelial cells of human endometrium. The two cell lines were screened for mRNA expression of 17beta-HSD 1-4 by RT-PCR and Northern blot. 17beta-HSD2 and 4 could be detected by either method, 17beta-HSD1 only by RT-PCR, 17beta-HSD3 not at all. Both cell lines were proven to have no receptor for progesterone which is known as a physiological inducer of several 17beta-HSD isozymes. To study the regulation of 17beta-HSD2 and 17betaHSD4, the concentration of fetal calf serum in the cell culture media was reduced stepwise to 0.3% by dilution with a defined serum replacement. This treatment led to an inhibition of 17beta-HSD2 mRNA expression and an increase in the mRNA expression of 17beta-HSD4. Concomitantly, distinct morphological changes were observed, such as a decrease in the number and length of microvilli and a decrease in the formation of domes on top of the monolayers. The endometrial epithelial cell lines HEC-1-A and RL95-2 represent a suitable in vitro model for further studies of the differential expression of the major endometrial HSD isozymes, independent of the effect of progesterone
On the universality of medical device regulations : the case of Benin
No full textBackground
Regulatory frameworks surrounding medical devices (MDs) and medical locations are of utter importance for safeguarding patients and users, and for granting a universal access to healthcare.
Currently, as the main existing regulatory frameworks are drafted by high-income countries, they pretend to be general and applicable globally, but fail to understand particular contexts, specifically those in low-resource settings (LRSs), resulting, therefore, inapplicable. In particular, LRSs present a varied situation, with legal transplants of guidelines from their previous colonial regimes. This apparently theoretical issue, is, effectively, a tangible and rising matter of concern, given the ever-increasing number of MD patent applications per year, as well as the appearance of low- and middle-income countries (LMICs) on the MD market itself.
This article will focus on the European Regulation on MDs 745/2017 and its applicability in LRSs, specifically presenting the case of Benin, a Sub-Saharan African country.
Methods
This work is based on a field study conducted in 2019 in Benin, which is particularly exemplar to show the complexity of the “legal transplantation” concept. A multidisciplinary approach, comprising the standard tools and methods of ethics, law, and biomedical engineering, was used to draft a heuristic hermeneutic framework, and to analyse related bioethical issues concerning Medical Device Regulations (MDRs) in LRSs, the role of Maintenance, and other sociological questions; as well as the rural population’s perception on MDs and health technologies, and the role of ethics in the hospitals of LRSs.
Results
The definition of these themes helped approach the local perspective and define the research questions. Downstream of the analysis of the Medical Devices Regulations, the Maintenance and other bioethical issues in Benin, the heuristic hermeneutic framework was created to guide a shift in the paradigm of law and regulation making, so as to make them more contextualised and inclusive, globally.
Conclusion
This article proposes a framework that will help policymakers take into account the particularism of each context, especially those of the most vulnerable countries, when drafting and issuing regulatory frameworks, promoting an ever-evolving model of universalis
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