1,355 research outputs found
The participation of women employed in traditionally male dominated occupations including plumbing: 1975–2013
No full textAuthor Garry Cruickshank investigates the gender gap in New Zealand’s plumbing profession. Having established that the proportion of female plumbers is almost unchanged since 1975, Cruickshank compares this information with data gathered from other trades and exposes the widespread nature of this trend across traditionally male dominated industries. The author reflects on what could to be done to alter this situation
Cruickshank, Diane
No full textcurrentI was born and raised in Vancouver and completed my B.A. in English Literature at UBC. I then moved to Europe: living in Pau, France for 6 months; then Oxford, England; London, England and finally ending up in Beaumaris, N. Wales. I did my MLIS equivalent at the University of Wales, Aberystwyth. My thesis was about computer-mediated communication and the long distance learner. I have worked in both public and academic libraries, in Canada and the U.K. I have been at UFV since 2006
Dan Cruickshank and Neil Burton, Life in the Georgian City
No full textDuval Gilles. Dan Cruickshank and Neil Burton, Life in the Georgian City. In: XVII-XVIII. Bulletin de la société d'études anglo-américaines des XVIIe et XVIIIe siècles. N°34, 1992. Éducation et savoir. Regard et vision, sous la direction de Paul Denizot. pp. 173-174
Dan Cruickshank and Neil Burton, Life in the Georgian City
No full textDuval Gilles. Dan Cruickshank and Neil Burton, Life in the Georgian City. In: XVII-XVIII. Bulletin de la société d'études anglo-américaines des XVIIe et XVIIIe siècles. N°34, 1992. Éducation et savoir. Regard et vision, sous la direction de Paul Denizot. pp. 173-174
Long term amphibian monitoring data from canton of Aargau
No full textData used in Cruickshank et al (2019). Conservation Science and Practice.Data provided with permission from the Canton of Aargau, Abteilung Landschaft und GewässerMetadata:Species: Species code (see legend in Figure 3 of Cruickshank et al (2019) for corresponding species names)Site: Site numberCoreArea: Core area to which a given site is assignedYear: YearSurvey: Survey number (1-3_Observed: binary detection-non detection data. NA's denote no survey was carried outExistence: Was the site part of the monitoring program during the given survey. 1=yes, 0=noHistoric: Was the species identified in the focal area in the historic surveys of Grossenbacher. 1=yes, 0=n
Working at the junction: reconciling numbers and vulnerabilities
No full textThe article discusses the need for a new approach to development that combines
human and qualitative insights with numerical analysis. It argues that the
traditional models of competitiveness, growth, and prosperity are no longer
sufficient, as the world undergoes a significant transformation, due to both digital
and green imperatives. Analysing the complexity and drivers of change, the
author points out that the digital transformation and the increased centrality of
data have made development models increasingly hinged on
quantitative/statistical analysis. The availability, centrality, and use of data
currently steer the way forward and occupy decision-makers’ minds, despite the
– often – skewed, flattened, and biased nature of data sets. To overcome these
limits, the article suggests looking at design practice as a way to balance
perspectives, working at the junction where the dominant logics of quantitative
analysis can be blended with qualitative and thick knowledge. This can help
reconcile humans and their vulnerabilities with numbers, leading to explore
intriguing new directions for research and practice
On Hyperstructure and Musical Structure
No full textIn this paper we report on an ongoing investigation into the relationship between musical structure and hyperstructure, based on a series of open hypermedia systems research projects that have featured case studies involving musical content. We provide a general overview of the intersection between hypermedia and musical structure, drawing also on ideas from narrative structure. Through the example systems we consider techniques for building hyperstructure from musical structure and, conversely, building musical structure from hyperstructure. Additionally we describe an experiment in the sonification of hyperstructure
Application of an affinity chromatography toolbox to drug repurposing for cancer therapeutics
No full textPhenotypic screening of drug molecules relies on the generation of a specific response;
however the means by which this is elicited often remains unknown. Affinity
chromatography is a valuable tool in the discovery of drug binding partners and may
even allow the elucidation of the wider interactome of the initial drug target. The
introduction of easily cleavable linkers and affinity-independent elution protocols to
affinity chromatography is of current interest, since they render the technique much
more adaptable with respect to the characterisation of biologically active species of
interest. This thesis details the application of a novel azobenzene linker developed by
the Hulme group for use in affinity-independent chromatography.
The first chapter reviews recent developments in affinity chromatography and
describes the synthesis of an affinity linker toolbox with both affinity-dependent and
affinity-independent linkers. These linkers are functionalised with an azide moiety for
use in CuAAC coupling to alkynyl derivatives of bioactive small molecules and have
been modified to include photoreactive groups giving a series of linkers for use in the
identification of less abundant, or low affinity, proteins.
The first drug investigated, anisomycin (ANS), is a small molecule which was initially
introduced as an antibiotic drug (Flagecidin). At nanomolar concentrations ANS has
been shown to affect the mitogen activated protein kinase (MAPK) pathways;
downstream effects of these pathways are thought to play a role in a range of
pathological disorders such as Alzheimer’s disease, cancer and spinal muscular
atrophy (SMA). ANS is thus a candidate for drug repurposing. Although the
downstream effects of MAPK/SAPK pathway activation induced by anisomycin are
well-documented, the cellular target has yet to be revealed. Previous work by the
Hulme group has shown that the N-propargyl anisomycin derivative (I) retains the
biological activity of the lead compound ANS. Thus to evaluate the cellular protein
targets, N-propargyl ANS (I) was coupled onto the linker toolbox to create an ANS
affinity probe library as described in chapter 2.
The second drug investigated, fingolimod, was introduced as an immunomodulating
drug (Glienya) for the treatment of multiple sclerosis (MS). This small molecule has
also been shown to have anti-cancer properties in a range of cancer cell lines; however
the precise mechanism by which this is effected is unknown. Literature precedent
shows that terminal modification of fingolimod generates analogues which still retain
biological activity. Thus a novel fingolimod alkyne derivative (II) was synthesised
and used to create an affinity probe library as described in chapter 3.
Chapter 4 describes affinity pull-down experiments conducted with the aim of finding
the protein target(s) of ANS and fingolimod, using the affinity probe libraries
generated in chapters 2 and 3. This chapter concludes with a discussion of the
implications of these findings and directions for future study
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