104 research outputs found
Epitaxial Growth of CoGa on (100)GaAs by Metal-Organic Molecular Beam Epitaxy
No full textABSTRACTEpitaxial layers of the intermetallic β-CoGa cubic phase were grown at low temperature on (100)GaAs by metal-organic molecular beam epitaxy (MOMBE) using GaEt3 and CpCo(CO)2 as vapor sources. The film composition and the lattice mismatch on (100)GaAs may be adjusted by controlling the molecular beam pressure ratio. The growth on a Co-saturated GaAs surface leads to the formation of bi-phased CoGa-CoAs films whereas epitaxial single-phased β-CoGa layers are grown on a Ga-terminated GaAs surface with the simple cube on cube orientation [100](001 )CoGa//[100](001)GaAs. Annealing experiments under inert atmosphere have shown that MOMBE CoGa films are thermally stable on GaAs until ca. 823 K. Ohmic and Schottky CoGa/GaAs contacts have been made depending on the doping of the substrate by this process.</jats:p
Remote Monitoring-Control System for Future Wearable-Portable Dialysis Devices
No full textMoving the dialysis treatment from the nephrology clinic to the patient’s point of need, instead of moving patients to the
nephrology clinic, is a great challenge today. The main objective of work presented in this the paper is the development of a
universal system, suitable for European environment, for the management, control and monitoring of wearable and portable
dialysis devices. The paper discusses its design and presents briefly the main components of the experimental Personal Health
System, emphasizing also the main advantages of using such approach. The results of implementing a dialysis device simulator
based on standard IEEE specification are also discussed. The system proposal is created based on collaboration among the
University of Applied Sciences Munich, Germany, the University of Padova, Italy, and the University of Groningen, the Netherlands
with participation of partner universities, hospitals and companies from Germany, Italy, and Romani
Genetic linkage analysis supports the presence of two susceptibility loci for alcoholism and heavy drinking on chromosome 1p22.1-11.2 and 1q21.3-24.2
No full textBackground: In order to confirm a previous finding of linkage to alcoholism on chromosome 1 we have carried out a genetic linkage study.Methods: DNA from eighteen families, densely affected by alcoholism, was used to genotype a set of polymorphic microsatellite markers at loci approximately 10 centimorgans apart spanning the short arm and part of the long arm of chromosome 1. Linkage analyses were performed using the classical lod score and a model- free method. Three different definitions of affection status were defined, these were 1. Heavy Drinking ( HD) where affected subjects drank more than the Royal College of Psychiatrists recommended weekly amount. 2. The Research Diagnostic Criteria for alcoholism ( RDCA) 3. Alcohol Dependence Syndrome ( ADS) as defined by Edwards and Gross ( 1976) and now incorporated into ICD10 and DSMIV.Results: Linkage analyses with the markers D1S1588, D1S2134, D1S1675 covering the cytogenetic region 1p22.1- 11.2 all gave positive two point and multipoint lods with a maximum lod of 1.8 at D1S1588 ( 1p22.1) for the RDCA definition of alcoholism. Another lod of 1.8 was found with D1S1653 in the region 1q21.3- 24.2 using the HD affection model.Conclusion: These results both support the presence of linkage in the 1p22.1- 11.2 region which was previously implicated by the USA Collaborative Study of the Genetics of Alcoholism ( COGA) study and also suggest the presence of another susceptibility locus at 1q21.3- 24.2
Organometallic CVD of CoGa and Related Bimetallic thin Films from Novel Single Source Precursors
No full textABSTRACTA series of volatile heterodinuclear organometallic compounds of the general formula L(CO)nM-ER1R2(D) (L = CO, η5-C5H5, P(CH3)3; n = 1–4; M = Mn, Fe, Co, Ni; E = Al, Ga, In; R = H, alkyl; D = O- or N-donor ligand) was syndiesized and characterized. These compounds exist either as low melting solids or liquids with vapor pressures typically around 10–50 mTorr at room temperature. The possibility to grow bimetallic thin films ME (e.g. CoAl, CoGa, Coin, Niln etc.) from those single source molecular precursors by thermally induced low pressure OMCVD was investigated. It was shown that the thin film composition, namely the metal stoichiometry, can be controlled by the ligand set at the metal atoms.</jats:p
Genome-wide association studies of the self-rating of effects of ethanol (SRE).
No full textThe level of response (LR) to alcohol as measured with the Self-Report of the Effects of Alcohol Retrospective Questionnaire (SRE) evaluates the number of standard drinks usually required for up to four effects. The need for a higher number of drinks for effects is genetically influenced and predicts higher risks for heavy drinking and alcohol problems. We conducted genome-wide association study (GWAS) in the African-American (COGA-AA, N = 1527 from 309 families) and European-American (COGA-EA, N = 4723 from 956 families) subsamples of the Collaborative Studies on the Genetics of Alcoholism (COGA) for two SRE scores: SRE-T (average of first five times of drinking, the period of heaviest drinking, and the most recent 3 months of consumption) and SRE-5 (the first five times of drinking). We then meta-analyzed the two COGA subsamples (COGA-AA + EA). Both SRE-T and SRE-5 were modestly heritable (h : 21%-31%) and genetically correlated with alcohol dependence (AD) and DSM-IV AD criterion count (r : 0.35-0.76). Genome-wide significant associations were observed (SRE-T: chromosomes 6, rs140154945, COGA-EA P = 3.30E-08 and 11, rs10647170, COGA-AA+EA P = 3.53E-09; SRE-5: chromosome13, rs4770359, COGA-AA P = 2.92E-08). Chromosome 11 was replicated in an EA dataset from the National Institute on Alcohol Abuse and Alcoholism intramural program. In silico functional analyses and RNA expression analyses suggest that the chromosome 6 locus is an eQTL for KIF25. Polygenic risk scores derived using the COGA SRE-T and SRE-5 GWAS predicted 0.47% to 2.48% of variances in AD and DSM-IV AD criterion count in independent datasets. This study highlights the genetic contribution of alcohol response phenotypes to the etiology of alcohol use disorders.AMSUNY DownstateHenri Begleiter Neurodynamics LaboratoryN/
Genome‐wide association studies of the self‐rating of effects of ethanol (SRE)
No full textThe level of response (LR) to alcohol as measured with the Self-Report of the Effects of Alcohol Retrospective Questionnaire (SRE) evaluates the number of standard drinks usually required for up to four effects. The need for a higher number of drinks for effects is genetically influenced and predicts higher risks for heavy drinking and alcohol problems. We conducted genome-wide association study (GWAS) in the African-American (COGA-AA, N = 1527 from 309 families) and European-American (COGA-EA, N = 4723 from 956 families) subsamples of the Collaborative Studies on the Genetics of Alcoholism (COGA) for two SRE scores: SRE-T (average of first five times of drinking, the period of heaviest drinking, and the most recent 3 months of consumption) and SRE-5 (the first five times of drinking). We then meta-analyzed the two COGA subsamples (COGA-AA + EA). Both SRE-T and SRE-5 were modestly heritable (h2 : 21%-31%) and genetically correlated with alcohol dependence (AD) and DSM-IV AD criterion count (rg : 0.35-0.76). Genome-wide significant associations were observed (SRE-T: chromosomes 6, rs140154945, COGA-EA P = 3.30E-08 and 11, rs10647170, COGA-AA+EA P = 3.53E-09; SRE-5: chromosome13, rs4770359, COGA-AA P = 2.92E-08). Chromosome 11 was replicated in an EA dataset from the National Institute on Alcohol Abuse and Alcoholism intramural program. In silico functional analyses and RNA expression analyses suggest that the chromosome 6 locus is an eQTL for KIF25. Polygenic risk scores derived using the COGA SRE-T and SRE-5 GWAS predicted 0.47% to 2.48% of variances in AD and DSM-IV AD criterion count in independent datasets. This study highlights the genetic contribution of alcohol response phenotypes to the etiology of alcohol use disorders
Fabrication and Electrical Properties of MBE Grown Metal-Gallium and Metal-Arsenic Compounds on Ga<sub>1-x</sub>Al<sub>x</sub>As
No full textABSTRACTFilms of CoGa and CoAs have been deposited on Ga1-xAlxAs surfaces. CoAs films were found to be highly textured, but not single crystal. For CoGa films, however, single crystal growth was observed. The crystalline quality of the (100) oriented CoGa was good as determined by Rutherford backscattering with channeling measurements (χmin ∼7%) and cross-sectional transmission electron microscopy. Schottky barrier diodes fabricated from (100)CoGa/Ga1-xAlxAs and CoAs/Ga1-xAlxAs showed good characteristics with low ideality factors, n<1.15. Good Schottky barrier behavior was also found for (100)ErAs/GaAs structures.</jats:p
A citation-based document retrieval system for finding research expertise
No full textCurrent citation-based document retrieval systems generally offer only limited search facilities, such as author search. In order to facilitate more advanced search functions, we have developed a significantly improved system that employs two novel techniques: Context-based Cluster Analysis (CCA) and Context-based Ontology Generation frAmework (COGA). CCA aims to extract relevant information from clusters originally obtained from disparate clustering methods by building relationships between them. The built relationships are then represented as formal context using the Formal Concept Analysis (FCA) technique. COGA aims to generate ontology from clusters relationship built by CCA. By combining these two techniques, we are able to perform ontology learning from a citation database using clustering results. We have implemented the improved system and have demonstrated its use for finding research domain expertise. We have also conducted performance evaluation on the system and the results are encouraging
Polygenic influences on the behavioral effects of alcohol withdrawal in a mixed-ancestry population from the collaborative study on the genetics of alcoholism (COGA)
No full textAlcohol withdrawal (AW) is a feature of alcohol use disorder that may occur in up to half of individuals with chronic, heavy alcohol consumption whenever alcohol use is abruptly stopped or significantly reduced. To date, few genes have been robustly associated with AW; this may be partly due to most studies defining AW as a binary construct despite the multiple symptoms and their range in severity from mild to severe. The current study examined the effects of genome-wide loci on a factor score for AW in high risk and community family samples in the Collaborative Study for the Genetics of Alcoholism (COGA). In addition, we tested whether differentially expressed genes associated with alcohol withdrawal in model organisms are enriched in human genome-wide association study (GWAS) effects. Analyses employed roughly equal numbers of males and females (mean age 35, standard deviation = 15; total N = 8009) and included individuals from multiple ancestral backgrounds. Genomic data were imputed to the HRC reference panel and underwent strict quality control procedures using Plink2. Analyses controlled for age, sex, and population stratification effects using ancestral principal components. We found support that AW is a polygenic disease (SNP-heritability = 0.08 [95 % CI = 0.01, 0.15; pedigree-based heritability = 0.12 [0.08,0.16]. We identified five single nucleotide variants that met genomewide significance, some of which have previously been associated with alcohol phenotypes. Gene-level analyses suggest a role for COL19A1 in AW; H-MAGMA analyses implicated 12 genes associated with AW. Cross-species enrichment analyses indicated that variation within genes identified in model organism studies explained \u3c1 \u3e% of the phenotypic variability in human AW. Notably, the surrounding regulatory regions of model organism genes explained more variance than expected by chance, indicating that these regulatory regions and gene sets may be important for human AW. Lastly, when comparing the overlap in genes identified from the human GWAS and H-MAGMA analyses with the genes identified from the animal studies, there was modest overlap, indicating some convergence between the methods and organisms
Genomic risk for post-traumatic stress disorder in families densely affected with alcohol use disorders
No full textRecent genome-wide association studies (GWAS) have identified genetic markers of post-traumatic stress disorder (PTSD) in civilian and military populations. However, studies have yet to examine the genetics of PTSD while factoring in risk for alcohol dependence, which commonly co-occur. We examined genome-wide associations for DSM-IV PTSD among 4,978 trauma-exposed participants (31% with alcohol dependence, 50% female, 30% African ancestry) from the Collaborative Study on the Genetics of Alcoholism (COGA). We also examined associations of polygenic risk scores (PRS) derived from the Psychiatric Genomics Consortium (PGC)-PTSD Freeze 2 (N = 3533) and Million Veterans Program GWAS of PTSD (N = 5200) with PTSD and substance dependence in COGA, and moderating effects of sex and alcohol dependence. 7.3% of COGA participants met criteria for PTSD, with higher rates in females (10.1%) and those with alcohol dependence (12.3%). No independent loci met genome-wide significance in the PTSD meta-analysis of European (EA) and African ancestry (AA) participants. The PGC-PTSD PRS was associated with increased risk for PTSD (B = 0.126, p \u3c 0.001), alcohol dependence (B = 0.231, p \u3c 0.001), and cocaine dependence (B = 0.086, p \u3c 0.01) in EA individuals. A significant interaction was observed, such that EA individuals with alcohol dependence and higher polygenic risk for PTSD were more likely to have PTSD (B = 0.090, p \u3c 0.01) than those without alcohol dependence. These results further support the importance of examining substance dependence, specifically alcohol dependence, and PTSD together when investigating genetic influence on these disorders
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