734 research outputs found
Brother Clair Stanislaus Battersby
No full textBrother Clair, also known as William John Battersby, was a prolific author, writing about the history of Christian Brothers College as well as the lives of Brothers of the De La Salle order
Edward Battersby Bailey, James Hutton - the Founder of Modern Geology
No full textTaylor Lawrence. Edward Battersby Bailey, James Hutton - the Founder of Modern Geology. In: Revue d'histoire des sciences, tome 28, n°1, 1975. p. 96
Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase pathway
No full textProstaglandin E(2) (PGE(2)) has been shown to modulate angiogenesis and tumour progression via the E-series prostanoid-2 (EP2) receptor. Endometrial adenocarcinomas may be exposed to endogenous PGE(2) and exogenous PGE(2), present at high concentration in seminal plasma
Edward Battersby Bailey, James Hutton - the Founder of Modern Geology
No full textTaylor Lawrence. Edward Battersby Bailey, James Hutton - the Founder of Modern Geology. In: Revue d'histoire des sciences, tome 28, n°1, 1975. p. 96
Intracerebral haemorrhage on oral anticoagulants and adherence to reversal guidelines
No full textIntroduction: 15% of acute stroke patients suffer an intracerebral haemorrhage (ICH) and up to 20% of patients are on anticoagulation namely warfarin or direct oral anticoagulants (DOACs). Early haemostatic treatment limits haematoma size and growth and this is reflected in recently updated NICEguidelines which highlight the need for emergency treatment to improve prognosis.Method: A retrospective audit was performed to assess the proportion of patients presenting with intracerebral haemorrhage on anticoagulation, and if so, to assess whether timely reversal agents were administered.Results: 17/137 patients with intracerebral haemorrhage were on anticoagulation. 16/17 patients were given a reversal agent but only 12/17 were given both vitamin K and octaplex. These findings representan 82% adherence to national guidelines.Conclusion: Further data and a trustwide audit which include more recent guidance in reversing DOACs are needed to improve performance and outcomes in acute intracerebral haemorrhage.A new departmental guideline for ICH has been finalised and the intention is to use this to benchmark future audit against national standards
Recommended from our members
A flexible object orientated design approach for the realisation of assistive technology
No full textThis thesis contributes to a growing body of research conducted by the Interactive Systems Research Group (ISRG) at Nottingham Trent University within the fields of accessibility and accessible technologies. Core to this research is the exploration of how interactive technologies can be developed and applied as platforms for education, rehabilitation and social inclusion. To this end the group has been actively evolving the User Sensitive and Inclusive Design (USID) methodology for the design, development and evaluation of accessible software and related technologies. This thesis contributes to the further development of the USID method with a focus on its application for the design of assistive technology
Moving together: the organisation of non-verbal cues during multiparty conversation
No full textPhDConversation is a collaborative activity. In face-to-face interactions interlocutors have mutual
access to a shared space. This thesis aims to explore the shared space as a resource for coordinating
conversation. As well demonstrated in studies of two-person conversations, interlocutors
can coordinate their speech and non-verbal behaviour in ways that manage the unfolding conversation.
However, when scaling up from two people to three people interacting, the coordination
challenges that the interlocutors face increase. In particular speakers must manage multiple listeners.
This thesis examines the use of interlocutors’ bodies in shared space to coordinate their
multiparty dialogue.
The approach exploits corpora of motion captured triadic interactions. The thesis first explores
how interlocutors coordinate their speech and non-verbal behaviour. Inter-person relationships
are examined and compared with artificially created triples who did not interact. Results demonstrate
that interlocutors avoid speaking and gesturing over each other, but tend to nod together.
Evidence is presented that the two recipients of an utterance have different patterns of head and
hand movement, and that some of the regularities of movement are correlated with the task structure.
The empirical section concludes by uncovering a class of coordination events, termed simultaneous
engagement events, that are unique to multiparty dialogue. They are constructed using
combinations of speaker head orientation and gesture orientation. The events coordinate multiple
recipients of the dialogue and potentially arise as a result of the greater coordination challenges
that interlocutors face. They are marked in requiring a mutually accessible shared space in order
to be considered an effective interactional cue.
The thesis provides quantitative evidence that interlocutors’ head and hand movements are
organised by their dialogue state and the task responsibilities that the bear. It is argued that a
shared interaction space becomes a more important interactional resource when conversations
scale up to three people
A Novel Antiinflammatory Role for the Short-Chain Fatty Acids in Human Labor
No full textHuman parturition is an inflammatory process that can be activated prematurely by pathological stimuli. This study investigated the expression of G protein-coupled receptors GPR43 and GPR41 receptors in human uteroplacental tissues and the role of short-chain fatty acids (SCFA) in modulating inflammatory pathways in fetal membranes. Expression of GPR43 and GPR41 was investigated in uteroplacental tissues collected from women delivering at term or preterm after ethical approval and patient informed consent. The effect of SCFA on expression of inflammatory genes was assessed in amnion explants after culture with a mimetic of infection (lipopolysaccharide, LPS). Sodium propionate effect on LPS-induced neutrophil chemotaxis was evaluated by transwell assay. GPR43 and GPR41 mRNA expression was higher in myometrium and fetal membranes collected from women after the onset of labor. GPR43 protein expression localized to immune cells and vascular endothelium in the myometrium and epithelium of fetal membranes. Treatment with LPS significantly increased mRNA expression of GPR43 and inflammatory genes. Cotreatment with LPS and sodium propionate decreased LPS-induced expression of inflammatory genes including IL-6, IL-8, cyclooxygenase-2, IL-1α, intercellular adhesion molecule-1, and platelet endothelial cell adhesion molecule-1 but not IL-1β or lymphocyte function-associated antigen-1. Sodium propionate reduced LPS-induced neutrophil chemotaxis and protein secretion of the neutrophil chemoattractant IL-8. Finally, fetal membrane expression of GPR43 was significantly higher in women delivering preterm with evidence of infection. GPR43-SCFA interactions may represent novel pathways that regulate inflammatory processes involved in human labor. Suppression of inflammatory pathways by SCFA may be therapeutically beneficial for pregnant women at risk of pathogen-induced preterm delivery
- …
