4,094 research outputs found
1.1 “Il Protocollo per la Gestione Integrata delle Zone Costiere (ICZM)“; 1.2. “La tabella di marcia per la pianificazione dello Spazio Marittimo (MSP)”; 1.3. “La cerniera tra terra e mare: il Progetto S.H.A.P.E.” e Palmieri N, (2014).“Aspetti socioeconomici”
No full textConsumers’ willingness to consume sustainable and local wine in Italy
No full textWine production is a relevant sector of the Italian economy and recently consumer demand has drastically changed due to their orientation towards new attributes of quality wines. Sustainability aspects are credence attributes that have an effect on consumers’ perceived quality. Moreover, local production of wine is seen as a sign of quality. However, much is still to be studied about drivers that can push consumers towards new quality attributes of wine such as sustainability and local production. Profiling consumers could be a first step to better understand consumers’ decisions on local and sustainable wine. Thus, the paper has the purpose of understanding the Italian consumers’ willingness to consume sustainable and local wine. Data has been collected from a sample of Italian consumers (N=1,099) using a web-based survey. A binary logistic regression model, selected on the basis of the model AIC was used. The findings showed the large majority of the interviewed are willing to consume local and sustainable wine
Mitochondrial carriers and related diseases
No full textSince the end of nineties numerous mitochondrial diseases have been found to be related to mutations in nuclear genes encoding mitochondrial carriers, a family of proteins that shuttle a variety of metabolites across the mitochondrial membrane. To date eleven disorders are known to be caused by defects of mitochondrial carriers. Mutations of mitochondrial carrier genes are responsible for carnitine/acylcarnitine carrier deficiency, ornithine carrier deficiency (HHH syndrome), aspartate/glutamate isoform 1 deficiency (global cerebral hypomyelination), aspartate/glutamate isoform 2 deficiency (CTLN2 and NICCD), amish microcephaly, neonatal myoclonic epilepsy, congenital sideroblastic anemia, PiC deficiency, ADP/ATP carrier isoform 1 deficiency and involved in neuropathy and bilateral striatal necrosis and adPEO (autosomal dominant progressive external ophthalmoplegia). We propose un updated overview of these diseases. We shall also discuss the role of missense mutations in impairing mitochondrial carrier function and the consequent severe damage to the mitochondrial matrix supply with substrates destined to specific metabolic pathways. Despite the substantial progress that has been made in our understanding of the molecular bases of mitochondrial carrier associated diseases, specific pharmacological therapies are not yet available. Current therapies are symptomatic and usually based on specific dietary measures. New therapeutic approaches are under investigation for some of these diseases.
For further reading
Palmieri F. (2008) Diseases caused by defects of mitochondrial carriers: a review. Biochim Biophys Acta; 1777:564-78.
Palmieri F, Pierri CL (2010) Structure and function of mitochondrial carriers - Role of the transmembrane helix P and G residues in the gating and transport mechanism. FEBS Lett. 584:1931-9.
Tessa A, Fiermonte G, Dionisi-Vici C, Paradies E, Baumgartner MR, Chien YH,Loguercio C, de Baulny HO, Nassogne MC, Schiff M, Deodato F, Parenti G, Rutledge SL, Vilaseca MA, Melone MA, Scarano G, Aldamiz-Echevarría L, Besley G, Walter J, Martinez-Hernandez E, Hernandez JM, Pierri CL, Palmieri F, Santorelli FM. (2009) Identification of novel mutations in the SLC25A15 gene in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome: a clinical, molecular, and functional study. Human Mutation; 30:741-8.
Wibom R, Lasorsa FM, Töhönen V, Barbaro M, Sterky FH, Kucinski T, Naess K, Jonsson M, Pierri CL, Palmieri F, Wedell A. (2009) AGC1 deficiency associated with global cerebral hypomyelination. N Engl J Med.; 361:489-95.
Iacobazzi V, Convertini P, Infantino V, Scarcia P, Todisco S, Palmieri F. (2009) Statins, fibrates and retinoic acid upregulate mitochondrial acylcarinitine carrier gene expression. Biochem Biophys Res Commun.; 388:643-7
The Educational Civic Path in Southern Italy: What Determines Behaviors Toward Food Waste Among Students in Campania Region?
No full textFood waste prevention has become an issue of international
concern, with Sustainable Development Goal 12.3 aiming to
halve per capita global food waste by 2030. Students are
most inclined to waste food, and thus they need to be investigated.
The study focused on students’ behavior toward food
waste in Campania region (Southern Italy) to address the educational
civic path expected by the Ministry of Education. A
web survey involving 409 students was used to investigate
the food waste behavior within the framework of the Theory
of Planned Behavior. The findings suggest that concern about
food waste, moral attitude and perceived behavioral control
influence individuals’ intentions to act and this in turn, translates
into correct behavior toward food waste. The recognition
of the factors that affect students’ behavior toward food waste
represents an important starting point to develop and implement
different anti-waste strategies at national and
regional levels
L'ipogeo Palmieri di Lecce
No full textGilda L'Arab, L'ipogeo Palmieri di Lecce, p. 457-497.
Realizzato nell'ultimo quarto del IV secolo a.C. all'interno delle fortificazioni messapiche di Lupiae, l'ipogeo Palmieri presenta una pianta a croce con dromos d'accesso a scala in linea con le coeve manifestazioni architettoniche daune ed etrusche. L'elemento caratterizzante del complesso è costituito dalla ricca decorazione scultorea, che comprende i capitelli d'anta figurati ai lati delle porte delle tre celle e due fregi che corrono ciascuno lungo le pareti del dromos. I fregi, l'uno decorato con una scena di combattimento tra guerrieri a piedi e a cavallo, l'altro con racemi floreali ai lati di una Rankengöttin, mostrano una piena aderenza tematica e stilistica ai rilievi tarantini in pietra tenera ed in generale alla koinè artistica degli inizi dell'Ellenismo ; all'interno di tale koinè emergono qui in particolar modo gli apporti delle tombe trace e macedoni.L'Arab Gilda. L'ipogeo Palmieri di Lecce. In: Mélanges de l'École française de Rome. Antiquité, tome 103, n°2. 1991. pp. 457-497
How to develop the periphery: the case of Basso Ferrarese in Italy
No full textThis paper combines and finalises two previous pieces of research by Melloni [2008] and Palmieri [2008]. It presents and discusses the results obtained applying CGE, NEG and New-NEG models to the Italian area of the “Basso-Ferrarese” and compares them with new CGE simulations that have been specifically designed for the same area, taking into considerations the peculiar and unique territorial factors that characterise the study-area.
In the first part, we introduce a preliminary comparison between the different results obtained with the previous simulations and, subsequently, we discuss them in the context of the territorial factors judged as more relevant for the area of Basso Ferrarese. In particular, we summarise the results obtained through simulations made with the CGE, NEG and the New-NEG models. Those counterfactuals study several aspects of the economy of Basso Ferrarese and deal with the expected impact of possible shocks in different areas. In particular, the CGE model analyses the effects on the economy of the study-area of four different shocks. Two of them, a change in labour supply and a change in the infrastructures endowment/cost, are related to the supply side (and are analysed also by the NEG and New-NEG models); the third one is a demand-side shock, an increase in the demand for tourism-services (as well as increases in other demand components, less interesting for the Basso Ferrarese case). Finally, the fourth shock is related to a possible change of the CAP, in other words an external shocks which is particularly relevant for the TERA case as agriculture plays a major role in the economy of remote rural areas.
The second part introduces a new set of CGE simulations that have been developed taking in full consideration the characteristics of the territory so to offer a more punctual and precise view over the perspectives for future development and the implications for the policy-makers.
The third part deals with a final comparison of all the results obtained, in particular concentrating its focus on the movements of the labour supply and the effects of trade integration.
In the fourth part, we discuss the results and we present the possible policy-scenarios according to the results of the simulations
The development of periphery in an industrialised country: the case of Basso Ferrarese in Italy
No full textThis paper combines and finalises two previous pieces of research by Melloni [2008] and Palmieri [2008]. It presents and discusses the results obtained applying CGE, NEG and New-NEG models to the Italian area of the “Basso-Ferrarese” and compares them with new CGE simulations that have been specifically designed for the same area, taking into considerations the peculiar and unique territorial factors that characterise the study-area.
In the first part, we introduce a preliminary comparison between the different results obtained with the previous simulations and, subsequently, we discuss them in the context of the territorial factors judged as more relevant for the area of Basso Ferrarese. In particular, we summarise the results obtained through simulations made with the CGE, NEG and the New-NEG models. Those counterfactuals study several aspects of the economy of Basso Ferrarese and deal with the expected impact of possible shocks in different areas. In particular, the CGE model analyses the effects on the economy of the study-area of four different shocks. Two of them, a change in labour supply and a change in the infrastructures endowment/cost, are related to the supply side (and are analysed also by the NEG and New-NEG models); the third one is a demand-side shock, an increase in the demand for tourism-services (as well as increases in other demand components, less interesting for the Basso Ferrarese case). Finally, the fourth shock is related to a possible change of the CAP, in other words an external shocks which is particularly relevant for the TERA case as agriculture plays a major role in the economy of remote rural areas.
The second part introduces a new set of CGE simulations that have been developed taking in full consideration the characteristics of the territory so to offer a more punctual and precise view over the perspectives for future development and the implications for the policy-makers.
The third part deals with a final comparison of all the results obtained, in particular concentrating its focus on the movements of the labour supply and the effects of trade integration.
In the fourth part, we discuss the results and we present the possible policy-scenarios according to the results of the simulations
Transport mechanism of mitochondrial carriers
No full textThe inner mitochondrial membrane contains a superfamily of proteins, called mitochondrial carriers (MCs), which transport several metabolites into and out of the mitochondrial matrix. As observed in the ADP/ATP carrier structure, crystallized in complex with its powerful inhibitor carboxyatractyloside, the main structural fold of the MCs consists of a barrel of six transmembrane α-helices whose charged surfaces form the wall of a water-filled cavity. Multiple sequence alignment and 3D comparative models of mitochondrial carriers of known function have recently allowed the identification of i) a similarly located binding site located in the carrier cavity, ii) two ion pair networks or gates that are on the matrix or the cytosolic side of the carrier molecules, and iii) two Pro-Gly levels above and below the substrate binding site. As a result of the substrate–protein interactions, ‘hinged helix movements’ consisting of a tilt of the entire helical segments and a kink/swivel of the helical termini at the level of their Pro and Gly have been proposed to be fundamental for the alternative opening and closure of the gates on the matrix or the cytosolic side and thus for the translocation mechanism. The key role of residues of the binding site, gates and Pro-Gly levels in substrate translocation is supported by the localization of most missense mutations found in patients affected by diseases associated to mitochondrial carriers.
References
Klingenberg M (2007 ) Transport viewed as a catalytic process. Biochimie. 89:1042-8.
Palmieri F (2008) Diseases caused by defects of mitochondrial carriers: a review. Biochim Biophys Acta 1777: 564-57
Palmieri F, Pierri CL (2010) Structure and function of mitochondrial carriers - Role of the transmembrane helix P and G residues in the gating and transport mechanism. FEBS Lett. 584:1931-9
Pebay-Peyroula E, Dahout-Gonzalez C, Kahn R, Trézéguet V, Lauquin GJ, Brandolin G. (2003) Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside. Nature. 426:39-44
Robinson AJ, Kunji ER. (2006) Mitochondrial carriers in the cytoplasmic state have a common substrate binding site. Proc Natl Acad Sci U S A. 103:2617-22
Robinson AJ, Overy C, Kunji ER. (2008) The mechanism of transport by mitochondrial carriers based on analysis of symmetry. Proc Natl Acad Sci U S A. 105:17766-71
Wibom R, Lasorsa F, Töhönen V, Barbaro M, Sterky F, Kucinski T, Naess K, Jonsson M, Pierri CL, Palmieri F, Wedell A (2009) AGC1 deficiency associated with global cerebral hypomyelination. N Engl J Med 361: 489-49
The potential for developing educational farms: a SWOT analysis from a case study
No full textPurpose: Educational farms (EFs) serve a number of social and
economic functions and are part of the debate about new
learning environments, multifunctional agriculture and firm
diversification. Through the analysis of a case study, this paper
aims to identify strengths and weaknesses, opportunities and
threats (SWOT) of EFs and key factors for setting a development
strategy.
Design/Methodology/Approach: A direct survey to EFs in Molise
region (IT) was implemented during April-May 2017 and results
were assessed following a SWOT approach.
Findings: Strong motivation and connection with agritourism
activities are strengths of EFs in the region; small size, unskilled
staff, lack of structured educational pathways, and limited
profitability are the main weaknesses. Farms opportunities come
from a territory rich in rural landscapes, environmental resources,
and typical food products, and from a growing demand for
educational tourism. Obstacles are in the institutional sphere and
due to the absence of regional networks. Based on SWOT
findings, key factors for EFs development are discussed.
Practical implications: EFs development requires innovative
educational and managerial tools, a more concerted and proactive
role for multiple stakeholders, and the implementation of a
network approach. Study findings solicit actions from public
institutions and advisory services to improve farmers’ skills.
Theoretical implications: The paper contributes to the theoretical
debate about the need for a multidisciplinary approach in dealing
with the analysis of EFs.
Originality/Value: The analysis underlines the importance of
internal and external drivers in stimulating farms and institutions
to support diversification strategies, rural development and
transformation processes in inner areas
A framework for assessing the relational accessibility of protected areas
No full textHuman - nature relationship concept has recently been reconsidered, emphasizing the benefits humans beings receive from ecosystems. This study moves from the awareness of the importance for organizations that manage protected areas to design strategies and actions aimed at improving the relatedness between the natural world and people, and between individuals. Starting from this premise, the study proposes a voluntary framework of relational accessibility, with the aim of improving the visitororganization relationship and the human-nature relatedness, and thus creating value for the organizations themselves. Afterdefining the relationshipconcept, the approach and the contentof the framework are set, based on multidisciplinary fields and approaches. The framework follows a cyclical approach and consists of a set of general and specific requirements and guidelines. To support the definition of the framework, relational accessibility is investigated within a specific protected area, through a focus group and a direct survey with children. The framework is then defined in more general terms, so that it can suitable for application to other environmental and organizational contexts. The relational accessibility framework is discussed with the managing board of the study site and compared with other sustainability tools. The implementation of the relational framework within the management system of protected areas could increase the social and economic value of these areas, while at the same time pursuing environmental goals
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