633 research outputs found
The Eternal Plan of the Father and the Immaculate Conception of the Mother: The Foundations of an Objective Mariology in the Theology of Blessed John Duns Scotus
No full textThis article explores selected aspects of the Mariology of Blessed John Duns Scotus, a medieval Franciscan philosopher and theologian. Even though the Subtle Doctor did not develop a theological synthesis as mature as that of St. Thomas Aquinas, his observations continue to provide a relevant source of inspiration for a more in-depth look at Franciscan protological and soteriological concepts. Duns Scotus earned his place in the history of theology as a eulogist of the mystery of the Incarnation and defender of the truth about the Immaculate Conception. In fact, what he had accomplished laid the necessary foundation for the dogmatic ruling on that matter in 1854. The article begins by presenting the scholar’s view of the relation between creation and Redemption from the standpoint of Christ’s perfect mediation. The Marian Doctor was an advocate of emphasizing the objectivity of Redemption, although he himself stopped short of the “threshold” of the mystery of the Father with respect to the Mother of the Son of God, the most perfect Mediator—also for the Virgin Mary. In the end, the Subtle Doctor did not draw all the possible conclusions from his theological vision of creation and salvation history. Next, the article outlines the perspective of God’s eternal plan. Blessed John Duns Scotus’s theology reveals a vision of history in which everything is directed toward the fulfilment of God’s eternal plan: the very plan of which St. Paul wrote very forcefully yet subtly and to which St. John Paul II often referred. The interpretation of that plan is the foundation of an “objective Mariology”. Finally, the author addresses the question of the freedom of both the Creator and His creation from the perspective of the Creator’s plan and in accordance with the Marian Doctor’s assumptions. An analysis of Duns Scotus’s Mariology reveals its depth and innovative character and, at the same time, certain limitations which—in his time—were mentally unsurmountable
Anestésicos locales: historia, acción farmacológica, mecanismo de acción, estructura química y reacciones adversas
No full textLa historia del descubrimiento de la anestesia óxido nítrico, cloroformo éter y su desarrollo es bien conocido. En 1880 una segunda revolución para mitigar el dolor produce la introducción de la anestesia local. 400-700 A.C. los antiguos indios peruanos que masticaban coca con alcalinos, conocían el adormecimiento en lengua y labios, que en quechua significa “kunka sukunka” (faringe adormecida).\nLa supresión del dolor era un desafío constante, siendo conocida la utilización de vegetales con propiedades anestésicas. El uso de cannabis, la masticación de coca, el alcohol y derivados del opio para citar algunos ejemplos.\nOtros investigadores, incluyendo a Sigmund Freud, también exploraron las propiedades anestésicas de la cocaína.\nSin embargo, como todas las drogas mágicas, el esplendor de la cocaína se debilitó. Aparecieron reportes como náuseas, vómitos y problemas cardíacos severos (incluyendo la muerte) así como problemas de adicción a la cocaína. Alfred Einhorn, un investigador alemán, describió muchas reacciones adversas asociadas a la cocaína mientras se investigaban químicos con propiedades anestésicas similares a la misma pero sin sus efectos de alteración. El primer producto de esta investigación, procaína, fue introducido en la medicina y en la odontología en 1904.\nFil: Smerilli, A. L. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Cirugía y Traumatología Buco Máxilo Facial I. Buenos Aires, Argentina.Fil: Sacot N. J. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Cirugía y Traumatología Buco Máxilo Facial I. Buenos Aires, Argentina
Facile 5-<i>endo</i> ring closures to the azo group. A free radical synthesis of indazoles
No full text Five 1-alkyl-3-methylindazoles were prepared by treatment of 1-(2-bromophenyl)-1-methoxy-1-(2-alkylazo)ethanes with tri-n-butyl stannane and AIBN at 80 °C in benzene. Yields in the radical cyclization step ranged from 39 to 92%. 1-Phenyl-3-methylindazole was prepared by an analogous route but in very poor yield (<5%). Rate constants for the 5-endo radical closures [Formula: see text], estimated by the radical clock method, were 5.2 × 109 s−1 and 9.2 × 108 s−1 for two of the alkyl systems. Rate constants for analogous 5-endo cyclizations of aryl radicals onto C—C double bonds are much smaller than those for cyclizations to the azo functional group. Keywords: cyclization, radical; azo group, radical closure to; indazoles, radical synthesis of. </jats:p
The effect of nutrient solution concentration on growth and quality of poinsettia ‘Premium Red’ cultivated on ebb-and-flow benches
No full textThe aim of the study was to examine responses of ‘Premium Red’ poinsettia
cultivated on ebb-and-flow benches at different nutrient solution concentrations (1.6,
2.0 and 2.4 mS·cm-1). Plants were grown at a greenhouse in 1.2 dm3 pots, filled in
TS2 medium. The highest plants with the largest diameters and best quality were
found when EC of the nutrient solution concentration was 2.0 or 2.4 mS·cm-1. At the
vegetative and bract coloration stages, leaves of plants supplied with nutrient solutions at 2.0 and 2.4 mS·cm-1 had higher status of chlorophyll than those of from nutrient solution of 1.6 mS·cm-1. As the nutrient solution concentration increased, both concentrations of salts and macronutrients (N-NO3, P, K, Ca, Mg) in the medium increased. It was concluded that in cultivation of poinsettia on ebb-and-flow benches, adequate EC value of nutrient solution concentration was 2.0 mS·cm-1
Gene Expression Profiling of Multiple Histone Deacetylases (HDAC) and Its Correlation with NRF2-Mediated Redox Regulation in the Pathogenesis of Diabetic Foot Ulcers
No full textNuclear factor erythroid-2-related factor 2 (Nrf2) is a protein of the leucine zipper family, which mitigates inflammation and employs cytoprotective effects. Attempting to unravel the epigenetic regulation of type 2 diabetes mellitus (T2DM) and diabetic foot ulcer (DFU), we profiled the expression of eleven isoform-specific histone deacetylases (HDACs) and correlated them with NRF2 and cytokines. This study recruited a total of 60 subjects and categorized into DFU patients (n = 20), T2DM patients (n = 20), and healthy controls (n = 20). The DFU patients were subcategorized into uninfected and infected DFU (n = 10 each). We observed a progressive decline in the expression of NRF2 and its downstream targets among T2DM and DFU subjects. The inflammatory markers IL-6 and TNF-α were significantly upregulated, whereas anti-inflammatory marker IL-10 was significantly downregulated in DFU. Of note, a significant upregulation of HDAC1, 3, 4, 11, SIRT3 and downregulation of HDAC2,8, SIRT1, SIRT2, SIRT3, SIRT7 among DFU patients were observed. The significant positive correlation between NRF2 and SIRT1 in DFU patients suggested the vital role of NRF2/SIRT1 in redox homeostasis and angiogenesis. In contrast, the significant negative correlation between NRF2 and HDAC1, 3 and 4, implied an imbalance in NRF2-HDAC1, 3, 4 circuit. Furthermore, a significant positive correlation was observed between HDAC4 and IL-6, and the negative correlation between SIRT1 and IL-6 suggested the pro-inflammatory role of HDAC4 and the anti-inflammatory role of SIRT1 in NRF2 signaling. In conclusion, the epigenetic changes such as upregulation of HDAC1, 3, 4, 11, SIRT3 and downregulation of HDAC2, 8, SIRT1, SIRT2, SIRT6, SIRT7 and their association with NRF2 as well as inflammatory markers are suggestive of their roles in pathophysiology of T2DM and DFU
Association of A1538G and C2437T single nucleotide polymorphisms in heat shock protein-70 genes with diabetic nephropathy among South Indian population
No full textDiabetic Nephropathy (DN) is the leading cause of end-stage renal disease, characterized by progressive albuminuria and conferring additional risk of cardiovascular disease (CVD) and mortality. The crucial role of heat-shock proteins (HSPs) on renal function in patients with DN has been well documented. The present study was aimed to understand the association of HSP-70 gene variants on the susceptibility of Type 2 Diabetes Mellitus (T2DM) and DN. A total of 946 subjects (549 Males; 397 Females) were recruited and divided into four groups according to the levels of urinary albumin excretion (UAE): those with normoalbuminuria (UAE &lt;30 mg/24 h; n=230), those with microalbuminuria (30≤ UAE ≤300 mg/24 h; n=230), and those with macroalbuminuria (UAE&gt; 300 mg/24 h; n=230). The control group randomly enrolled a consecutive population of 256 healthy subjects who had a routine medical check-up in our hospital. Those subjects had no history or clinical symptoms of diabetes. Subjects were genotyped for HSP70-2 (+1538 A/G; rs2763979) and HSP70-hom (+2437 C/T; rs2227956) by PCR-restriction fragment length polymorphism (RFLP). The ‘G’ allele of HSP70-2 (+1538 A/G) single nucleotide polymorphism (SNP) showed relative risk for normoalbuminuria, microalbuminuria and macroalbuminuria subjects whereas the ‘T’ allele of HSP70-hom (+2437 C/T) SNP showed significant protection against macroalbuminuria subjects. In conclusion, our results indicate that the HSP70-2 (+1538 A/G) and HSP70-hom (+2437 C/T) SNPs are highly associated with renal complications in T2DM among the South Indian population.</jats:p
Murrayon pullari
No full text220. Murrayon pullari (Murray, 1907 c) sensu lato [F] Macrobiotus pullari Murray. (Heinis 1914) M. pullari J. Murray, 1907 (du Bois-Reymond Marcus 1944, Rossi & Claps 1989) Murrayon pullari (J. Murray, 1907) (Garitano-Zavala 1995) M. pullari (Garitano-Zavala (1996) Terra typica: Scotland (Europe) Argentina: • 54 ° 50 ′S, 68 ° 29 ′W; 100 m asl: Tierra del Fuego Province, road to Lapataia, peat-bog, moss (Sphagnum sp.). Rossi & Claps (1989) Bolivia: • 16 ° 11 ′S, 68 ° 35 ′W; 3,680–4,000 m asl: La Paz Department, Cordillera de la Real de los Andes, Huarina, moorland floor, cushion moss. Garitano-Zavala (1995, 1996) • 16 ° 13 ′S, 68 ° 13 ′W; 4,550–4,700 m asl: La Paz Department, Cordillera de la Real de los Andes, Tuni, subnival floor, cushion moss. Garitano-Zavala (1995, 1996) • 16 ° 18 ′S, 68 ° 17 ′W; 4,300–4,400 m asl: La Paz Department, Cordillera de la Real de los Andes, Wila Kunka, high Andean floor, cushion moss. Garitano-Zavala (1995, 1996) • 16 ° 20 ′S, 68 ° 23 ′W; 4,650–4,700m asl: La Paz Department, Cordillera de la Real de los Andes, La Cumbre, subnival floor, cushion moss. Garitano-Zavala (1995, 1996) Brazil: • 23 ° 35 ′S, 46 ° 42 ′W; 750 m asl: São Paulo State, creeks of Rio Pinheiros, aquatic plants. du Bois-Reymond Marcus (1944) Colombia: • 04° 24 ′N, 76 ° 12 ′W; 1,600 m asl: Valle del Cavvuca Department, El Canon near El Aguacate, hepatics (Frullania longicolla L. & G. and Taxilejeunea prominata (Gottsche)). Heinis (1914) Record numbers: Argentina: 1, Bolivia: 4, Brazil: 1, Colombia: 1; total: 7. Remarks: A largely Holarctic species (McInnes 1994 a) suggest the South American records may be anomalous, and could indicate new taxa closely related to M. pullari.Published as part of Kaczmarek, Łukasz, Michalczyk, Łukasz & Mcinnes, Sandra J., 2015, Annotated zoogeography of non-marine Tardigrada. Part II: South America, pp. 1-107 in Zootaxa 3923 (1) on page 90, DOI: 10.11646/zootaxa.3923.1.1, http://zenodo.org/record/24193
Diphascon higginsi Binda 1971
No full text83. Diphascon higginsi Binda, 1971 [T] Diphascon (Diphascon) higginsi Binda, 1971 (Garitano-Zavala 1995) D. (D.) higginsi (Garitano-Zavala 1996) Terra typica: Morocco (Africa) Bolivia: • 16 ° 11 'S, 68 ° 35 'W; 3,680–4,000 m asl: La Paz Department, Cordillera de la Real de los Andes, Huarina, moorland floor, cushion moss. Garitano-Zavala (1995, 1996) • 16 ° 13 'S, 68 ° 13 'W; 4,550–4,700 m asl: La Paz Department, Cordillera de la Real de los Andes, Tuni, subnival floor, cushion moss. Garitano-Zavala (1995, 1996) • 16 ° 18 'S, 68 ° 17 'W; 4,300–4,400 m asl: La Paz Department, Cordillera de la Real de los Andes, Wila Kunka, high Andean floor, cushion moss. Gritano-Zavala (1995, 1996) • 16 ° 20 'S, 68 ° 23 'W; 4,650–4,700m asl: La Paz Department, Cordillera de la Real de los Andes, La Cumbre, subnival floor. cushion moss. Garitano-Zavala (1995, 1996) Colombia: • 11 °06′20.0′′N, 74 °03′50.0′′W; 2,200 m asl: Magdalena Department, Sierra Nevada de Santa Marta, between La Tagua and Cuchilla de San Lorenzo, sub-Andean forest, moss (Calymperaceae sp.) and lichen on rocks (2 samples). Lisi et al. (2014) Record numbers: Bolivia: 4, Colombia: 1; total: 5. Remarks: Species belong to the nobilei group in which few new species were described from Europe in recent years (Pilato & Bertolani 2005, Pilato et al. 2005). This species has a mainly European distribution with single reports from New Zealand, North and South America (McInnes 1994 a). Non-European records should be carefully re-examined, using integrative (molecular and morphology) taxonomy, as these could represent a complex of cryptic species.Published as part of Kaczmarek, Łukasz, Michalczyk, Łukasz & Mcinnes, Sandra J., 2015, Annotated zoogeography of non-marine Tardigrada. Part II: South America, pp. 1-107 in Zootaxa 3923 (1) on page 37, DOI: 10.11646/zootaxa.3923.1.1, http://zenodo.org/record/24193
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