1,721,192 research outputs found
Nostra esperienza sull’uso della norfloxacina somministrata per via orale nel trattamento delle infezioni acute e croniche dell’apparato urinario
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Efficacia e tollerabilità della norfloxacina somministrata per via orale nel trattamento delle infezioni urinarie
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Efficacia e tollerabilità dell’Aztreonam nella terapia delle infezioni urinarie sostenute da germi difficili e/o multiresistenti
No full textMedical-expulsive therapy for distal ureterolithiasis: a randomized prospective study on the role of corticosteroids used in combination with tamsulosin. Simplified treatment regimen and health-related quality of life.
No full textObjectives. To assess the clinical efficacy of the addition of a corticosteroid drug to tamsulosin in the
medical-expulsive therapy of distal ureterolithiasis.
Methods. Sixty consecutive patients with a symptomatic distal ureteral stone were included in our study
and randomized to one of two home treatment groups. Group 1 patients (n 30) received tamsulosin (0.4
mg daily), and group 2 patients (n 30) were treated with a corticosteroid drug (deflazacort, 30 mg daily)
plus tamsulosin. The treatment duration was until stone expulsion or 28 days, whichever came first. The
primary endpoint of the study was the stone expulsion rate. The secondary endpoints were the expulsion
time; use of analgesics; number of emergency room admissions, hospitalizations, and workdays lost; drug
side effects; and quality of life of the patients (EuroQol questionnaire, EQ-5D) during treatment.
Results. The two groups had a similar expulsion rate (90% for group 1 and 96.7% for group 2; P 0.612),
but the expulsion time was significantly reduced in group 2 patients (P 0.036). During the treatment
period, we did not observe significant differences between the two groups in the number of emergency room
visits or hospitalizations, analgesic use, number of workdays lost, or incidence of drug side effects. The
quality of life of the patients during therapy, as determined using the EQ-5D, was similar in both groups.
Conclusions. The use of a corticosteroid drug in association with tamsulosin seemed to induce more rapid
stone expulsion. In addition, tamsulosin alone as medical-expulsive therapy for distal ureteral calculi had
excellent expulsive effectiveness
Biological Selection Criteria for Radical Prostatectomy
No full textTumors clinically confined to the prostate gland (T1-2) are heterogeneous with respect to pathological staging and outcome after definitive radical surgery (radical prostatectomy). The preoperative prognostic factors that could predict pathological stage and outcome of individual patients with clinically localized prostate cancer are reviewed. New preoperative factors have been identified by histological analysis of needle biopsy prostate specimens in addition to Gleason grading score, serum markers (PSA), and clinical staging. These factors are related to tumor volume, zonal origin of the tumor, and spread into the gland and surrounding tissues. Other biological factors are identified by molecular and immunohistochemical analysis (neuroendocrine differentiation, DNA content, microvessel density, and perineural invasion). Biomolecular factors can also be assessed preoperatively on serum samples (free/total PSA ratio, PSA RT-PCR). Although only a few of these factors have a role in predicting treatment failure and/or disease recurrence, the neural network analysis seems to be the most important tool for identifying patients with more aggressive disease. A combination of these new factors, also using neural networks, could be relevant in the preoperative management of patients with prostate cancer to identify those with confined disease and to select those suitable for a "nerve sparing radical prostatectomy" to preserve sexual function and to achieve definitive cancer control
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