286 research outputs found
Czuły narrator w Zulejce Guzel Jachiny
No full textThe main assertion in this paper is that the tender narrator, whom the Polish writer, Olga Tokarczuk, made the subject of her Nobel Lecture, can convey the author’s perspective in such a way that all readers can find themselves in it. Using the example of Guzel Yakhina’s Zuleikha, the author of this paper demonstrates how tender narration brings out the titular character’s defenselessness as a quality of the human condition. The author ponders what distinguishes Yakhina’s novel among other examples of camp or historical literature and also addresses Hélène Cixous’s concept of l’écriture feminine, concluding that the perspective of tender narration is coextensive with the feminine narration that is open to voices arriving from a multitude of perspectives. The author also demonstrates that Yakhina’s Zuleikha is an example of literature that highlights and explores the experience of a human being’s internal freedom, which is inalienable, even though its external freedom may be endangered by fate, the laws of history or political machinations.Główną tezą tekstu jest przekonanie, że będące wyzwaniem dla literatury pięknej przekazanie perspektywy autora w taki sposób, by każdy czytelnik mógł w niej odnaleźć samego siebie, jest możliwe dla tzw. czułego narratora, któremu swoją mowę noblowską poświęciła polska pisarka Olga Tokarczuk. Na przykładzie powieści Guzel Jachiny pt. Zulejka otwiera oczy autorka tekstu pokazuje, w jaki sposób czuła narracja wydobywa z postaci głównej bohaterki jej bezbronność jako cechę kondycji człowieka. Zastanawia się nad tym, co wyróżnia powieść Jachiny na tle innych przykładów literatury obozowej czy historycznej. Podejmuje także problem pisarstwa kobiecego (l’écriture feminine), o którym pisała Hélène Cixous, dochodząc do wniosku, że perspektywa czułej narracji jest tożsama z perspektywą kobiecą otwartą na głosy dochodzące z różnych perspektyw. autorka pokazuje również, że Zulejka otwiera oczy to przykład literatury eksponującej i eksplorującej doświadczenie wewnętrznej wolności człowieka, które nawet w warunkach wolności zagrożonej przez los, prawa historii czy mechanizmy polityczne, nie może zostać utracone
The Doha Talks and the Bargaining Surplus in Agriculture
No full textThe Doha Round has been slow to achieve a reduction in the level of agricultural protection. This remains the case notwithstanding the substantial economic benefits that would arise from a more liberal agricultural trading regime. We provide one explanation for this slowness using a simple bargaining model. We demonstrate that the bargaining countries received a substantial fiscal gain from reducing government expenditures in the run-up to the Uruguay Round. This fiscal pressure was sufficient to block rent seekers who wanted farm payments to continue. Since the Uruguay Round these fiscal constraints have been reduced and the same pressure to reach a bargain and control rent-seeking behaviour is not present in the Doha Round.Doha Round, rent seeking, bargaining, International Relations/Trade,
Protocol for Cell Surface Biotinylation of Magnetic Labeled and Captured Human Peripheral Blood Mononuclear Cells
No full textGuner, Huseyin/0000-0002-0220-5224; Findik, Fatma/0000-0001-9165-3653; Ayaz Guner, Serife/0000-0002-1052-0961; Acar, Mustafa Burak/0000-0002-9109-6575; Guzel, Melis/0000-0002-5973-0839;Analysis of the surfaceome of a blood cell subset requires cell sorting, followed by surface protein enrichment. Here, we present a protocol combining magnet-ically activated cell sorting (MACS) and surface biotinylation of the target cell subset from human peripheral blood mononuclear cells (PBMCs). We describe the steps for isolating target cells and their in-column surface biotinylation, fol-lowed by isolation and mass spectrometry analysis of biotinylated proteins. The protocol enables in-column surface biotinylation of specific cell subsets with minimal membrane disruption.Scientific and Technological Research Council of Turkiye (TUBITAK) [119S457]This work was supported by The Scientific and Technological Research Council of Turkiye (TUBITAK) (Project Number: 119S457) to S.O. We thank Prof. Dr. Eugene STEELE for language editing. The graphical abstract and figures were created with BioRender.com
The Script Work in the Complex Object of Copyrights
No full textIn article the questions connected with features of the civil mode of the scenario work as a part of difficult objects of author's rights, such as audiovisual works are investigated (movies, film formats and others). The author in detail considers questions of concepts of the scenario work and a difficult object of author's rights. At the same time the special-purpose character of creation of the scenario work as object of an author's right, namely, for use as a part of difficult objects of author's rights reveals, the interconditionality of concepts, existence of two-level system of author's rights concerning a difficult object, namely, the rights for a difficult object, and the rights to results of intellectual activity which were used during creation of a difficult intellectual property item is proved
Effects of Iodixanol on Respiratory Functions during Coronary Angiography and the Role of Body Composition
No full textPurpose. The purposes of this study are to assess the acute effects of iodixanol, an iso-osmolar contrast media, on pulmonary functions and to evaluate the body composition in order to find out its role in causing this deterioration. Methods. 35 male and 25 female patients undergoing diagnostic coronary angiography (CA) were enrolled in the study. Before CA, all patients’ body compositions were evaluated by measuring their body mass indexes (BMIs) and waist-to-hip ratios (WHRs). Total body waters (TBWs), fat masses (FMs), fat-free masses (FFMs), and basal metabolism rates (BMRs) were measured via bioimpedance analysis. The CA was performed via radial artery route using iodixanol in every patient. The pulmonary function tests of these patients were performed before, during, and 2 hours after the CA. FEV1∆, FEF25–75%∆, and FVC∆ parameters were calculated by subtracting the measured baseline value from the measurement after the CA. Results. Angiography caused significant reduction in forced expiratory volume in 1 sec (FEV1, from 94.17 ± 18.83 to 84.45 ± 18.31, p<0.0001), forced vital capacity (FVC, from 96.57 ± 15.82 to 88.31 ± 17.96, p<0.0001), and forced expiratory flow at 25–75% (FEF25–75% from 82.54 ± 24.26 to 72.11 ± 25.41, p=0.001) and remained lower after 2 h after CA in male patients, respectively. FEV1 values were 103.40 ± 17.79 to 94.96 ± 17.063 (p=0.004); FVC values were 107.20 ± 19.03 to 99.08 ± 20.56 (p=0.009); and FEF25–75% values were 83.92 ± 24.30 to 73.24 ± 20.45 (p=0.005) before and after CA and remained lower after 2 h after CA in female patients, respectively. FEV1/FVC ratio remained unchanged. FEF25–75%∆ was statistically correlated with FFM, TBW, and WHR (p<0.05; r=−0.344, r=−0.347, and r=0.357, resp.), and FVC∆ was correlated with WHR in male patients (p=0.018, r=397). Conclusions. Our data suggested that diagnostic CA using iodixanol, an iso-osmolar contrast media, leads significant impairment in respiratory functions. Due to the persistence of these reductions even 2 hours after CA, ventilatory functions should be considered especially in patients whose body compositions or hydration levels are not within the desired physiological range
The Phenomenon of Guzel Yakhina: on the Reception of the Novel „Zuleikha Opens her Eyes”
No full textThe article analyzes salient aspects of Guzel Yakhina’s novel Zuleikha (Zuleikha opens her eyes) and its critical reception. First of all, the author discusses the connections of the artistic world of the novel with the Russian literary tradition with respect to the image of “the natural man”. Particular attention is paid to the treatment of the “eternal themes” of love, motherhood, faith, the formation of personality as well as to the originality with which the author approaches the topic of the mass repression of the 1930s. The predominating opinions of critics and reviewers are interpreted, and an attempt is made to indicate the reasons for the novel’s popularity with the readers.В статье анализируются значимые аспекты романа Г. Яхиной Зулейха открывает глаза и его восприятие критикой. В частности, рассматриваются связи художественного мира романа с традициями русской литературы в изображении «естественного человека», особенности звучания вечных тем любви, материнства, веры, становления личности, своеобразие раскрытия темы репрессий 1930-х годов. Осмыслены основные тенденции суждений критиков и рецензентов, сделана попытка объяснить причины успеха романа у читателей.
Output domain downscaler
No full textThis paper offers an area-efficient video downscaler hardware architecture, which we call Output Domain Downscaler (ODD). ODD is demonstrated through an implementation of the bilinear interpolation method combined with Edge Detection and Sharpening Spatial Filter. We compare ODD to a straight-forward implementation of the same combination of methods, which we call Input Domain Downscaler (IDD). IDD tries to output a new pixel of the downscaled video frame every time a new pixel of the original video frame is received. However, every once in a while, there is no downscaled pixel to produce, and hence, IDD stalls. IDD sometimes also skips a complete row of input pixels. ODD, on the other hand, spreads out the job of producing downscaled pixels almost uniformly over a frame. As a result, ODD is able to employ more resource sharing, i.e., can do the same job with fewer arithmetic units, thus offers a more area-efficient solution than IDD. In this paper, we explain how ODD and IDD work and also share their FPGA synthesis results.Artemis ; TÜBİTA
Studies of ionic mechanisms associated with human cancers
No full textThe general aim of this thesis was to undertake a series of inter-related studies with a
view to improving our understanding of the role of ion channel expression and its
regulation in cancer cells with strong metastatic potential. The emphasis was on
neonatal Nav1.5 (nNav1.5) subtype of voltage-gated sodium channel (VGSC).
Chapter 1 (General Introduction) gives an account of the relevant literature and states
the main aims of the studies. Chapter 2 details the Materials and Methods, ranging
from quantitative molecular biology to in vitro assays of metastatic cell behaviour.
Chapter 3 presents experiments on regulation of VGSCs by insulin and insulin-like
growth factor1 (IGF1) in strongly metastatic human breast cancer (BCa) MDA-MB-
231 cells. The central strategy was to treat insulin and IGF1 as an integrated
signalling system (”IIS”) and suppress it using pharmacological inhibitors and RNAi.
Inhibiting IIS signalling suppressed metastatic cell behaviours (MCBs) and
decreased nNav1.5 expression and activity. Chapter 4 describes studies on mRNA
expression of a variety of cancer-associated ion channels (CAICs) in peripheral
blood of normal human subjects with a view to laying the foundations for subsequent
patient-based studies. The following 8 CAICs were studied: nNav1.5, VGSC-β1,
VGSC-β1b, Kv1.3, Kv10.1, Kv11.1, KCa3.1 and TRPM8. Several differences were
noted between healthy cases and cancer patients. In particular, nNav1.5 and Kv1.3
mRNA expressions were up- and down-regulated, respectively. Chapter 5 shows that
the anti-diabetic drug Metformin suppressed Matrigel invasion and nNav1.5 mRNA
expression in MDA-MB-231 cells. Chapter 6 involves studies on the strongly
metastatic human colorectal cancer (CRCa) SW-620 cells, which were found to
express nNav1.5 mRNA and protein. Silencing nNav1.5 expression had a significant
inhibitory effect on Matrigel invasion. The thesis ends with a General Discussion and
Conclusion chapter, integrating the findings in the context of the field at large and
pointing to future directions
New Enantioselective Lewis Acid Catalysts
No full textRecently, many organic chemists have been ultimately interested in research in the synthesis of enantiomerically pure organics which are useful to synthesis of biologically active agents and prodrug substances. In the past decades, the new concepts in catalyst design unexpectedly explored the direction of natural product synthesis. In many cases, using enantioselective catalysts are the most suitable and efficient method into enantiopure systems
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