37 research outputs found

    Correlation of elevated leptin levels in amniotic fluid and maternal serum in neural tube defects

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    OBJECTIVE: To measure maternal serum and amniotic fluid leptin concentrations in pregnant women diagnosed antenatally as having fetuses with a neural tube defect in the second trimester

    Long-term effects of continuous oral and transdermal estrogen replacement therapy on sex hormone binding globulin and free testosterone levels

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    Objective: To determine the long-term effects of estrogen replacement therapy on sex hormone binding globuline (SHBG) and free testosterone (fT) levels in surgical postmenopausal women. Study Design: Forty patients with surgical menopause were enrolled in this prospective study. The women were randomly divided into two groups. The first group received oral therapy (continuous conjugated equine estrogens (CEE) - 0.625 mg per day) and the second group received transdermal therapy (patches delivering continuous 17 beta -estradiol (E2) - 0.05 mg per day). Serum SHBG and fT levels were determined at baseline and after first and second years of treatment. Two-way repeated measures analysis of variance with Bonferroni adjusted post-hoc test and unpaired-t-test were performed for statistical analysis with SPSS program. Results: Serum SHBG levels increased significantly with oral CEE after first year of treatment (P < 0.05) and remained at this level for the next year. Transdermal therapy did not affect SHBG levels after first and second years (P < 0.05). Serum fT levels did not change significantly in either group at the end of the first or second years (P < 0.05) although there was a significant difference between the groups after 2 years (P < 0.05). Conclusion: Oral conjugated estrogens increased SHBG levels during therapy. This effect may balance the increased estrogen and androgen stimulation on breast tissue and may be more beneficial to the cardiovascular system in postmenopausal women. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved

    Correlation between maternal thyroid function tests and endothelin in preeclampsia-eclampsia

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    Objective: To investigate the relationship between results of maternal thyroid function tests and endothelin levels in preeclamptic or eclamptic women

    Prenatal ultrasonographic diagnosis of rhizomelic chondrodysplasia punctata by detection of rhizomelic shortening and bilateral cataracts

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    Antenatal sonographic diagnosis of rhizomelic chondrodysplasia punctata depends on recognization of the combination of rhizomelic bone shortening and epiphyseal stippling. This is the only report of prenatal ultrasonographic diagnosis of bilateral cataracts in a fetus with rhizomelic chondrodysplasia punctata (type 1). Also, this is the first report of severe rhizomelic limb shortening, and bilateral cataracts prior to the recognization of epiphyseal stippling. Copyright (C) 2005 S. Karger AG, Basel
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