1,721,058 research outputs found
Il vetro nella Sardegna medievale: nuovi dati dall'indagine archeologica del Palazzo di Baldu (Luogosanto, OT)
No full textThe study of the glass finds from the archaeological excavations of the Santu Stevanu-Lu Palazzu di Baldu settlement, in the historical region of Gallura, in addition to providing important information about the function and chronology of the building complex, contributes to the knowledge of the trade relations occurred in Middle Ages between Sardinia and other Mediterranean areas, and indicates the additional possibility of contacts, thus far archaeologically unattested on the island, with territories such as the Islamic Near East
Impact of sphincter invasion on T stage definition in rectal cancer
No full textDear Editor: Uniform stage is the strongest predictor of survival for patients with rectal cancer. Accurate staging is paramount for appropriate patient management and clinical research comparison. Historically, tumor staging is based on local tumor characteristics (T), lymph nodes involvement (N), and presence of distant metastasis (M). In the seventh edition of the American Joint Committee on Cancer (AJCC) staging, T4 was subdivided into T4a (tumor penetrates to the surface of thevisceralperitoneum) andT4b(tumordirectlyinvadesoris adherent to other organs or structures) [1]. These changes were supported by SEER rectal cancer outcomes data that showed a 10 % improvement in 5-year overall survival in patients with T4a lesion compared with T4b [2]
Osteoradionecrosis and intensity modulated radiation therapy: an overview
No full textOsteoradionecrosis (ORN) is an ongoing topic, especially about its definition, pathogenesis, staging system and management algorithm. But what about its real incidence in intensity modulated radiotherapy (IMRT) era? This paper discusses the mandible in radiation therapy planning as organ at risk and reviews the literature for evidence of radiation damage, discussing likely dose constraints and the use of IMRT to reduce radiation dose to this structure. PubMed search was performed
Radiation target volume definition after induction chemotherapy in locally advanced rectal cancer
No full textNeo-adjuvant treatment field design in locally advanced
rectal cancer (LARC) is based on patterns of failure data.
Considering that outcomes depend on both tumor (T) and
node (N) stage, radiation therapy field arrangement is highly
correlated with the primary tumor location as well as the areas
and the distribution of lymph nodes judged to be at risk for
local recurrenc
Does the addition of induction chemotherapy improve outcome in locally advanced rectal carcinoma?
Full text linkLocally advanced rectal cancer (LARC) is defined as directly
tumor invasion into the pericolorectal tissues (T3) and
other organs or structures (T4), and/or metastasis in regional
lymph node (N+). The treatment of LARC is multidisciplinary,
and neo-adjuvant chemoradiotherapy (CRT) followed by
surgery is the standard of care in this setting of patients, based
on the CAO/ARO/AIO-94 German Rectal Cancer Study. This
study compared neo-adjuvant versus adjuvant CRT regimen
in a cohort of 823 patients with LARC. Neo-adjuvant CRT
improved local control (6 versus 13 %, p=0.02), as well as
sphincter preservation (39 versus 19 %, p=0.004) and decreased
acute and late toxicity (27 versus 40 % and 14 versus
24 %, respectively) compared with post-operative CR
Locally advanced anal canal carcinoma: is the addition of cetuximab the answer?
No full textCarcinoma of the anal canal is a rare disease accounting
7.270 estimated new cancer cases in 2015, with increasing
incidence over the last decades [1]. The efficacy of radiation
therapy combined with chemotherapy (CRT) as treatment for
anal canal carcinoma has been convincingly proven. Prior to
the 1970s, treatment consisted of radical surgery with
abdominoperineal resection. Relying on Nigro’s intuitions,
several randomized clinical trials tested the use of radiotherapy
combined with chemotherapy and demonstrated a significantly
higher colostomy-free survival with the addition of
mitomycin-C (MMC) to infusional 5-fluorouracil (5-FU)
and radiation. This method was first described by Nigro in
1974. Since then, no other effective treatment was developed—
two randomized trials tested whether cisplatin
(CDDP) could be used instead of MMC to improve local
and distant control, but results failed in their objectiv
Mastication structures definition in head and neck cancer
No full textWe analyzed the consensus guidelines from the study published in Radiotherapy & Oncology by Brouwer et al. [1]. The topic is interesting and the final atlas attractive
Follow-up in head and neck cancer: a management dilemma
Full text linkFollow-up program in squamous cell carcinoma of head and neck district is crucial to detect locoregional recurrence and second
primary tumors and to manage treatment toxicities. The choice of the appropriate frequency of visits and imaging modality can be
troublesome. Details of timing surveillance and type of diagnostic procedure are still not well defined. This review highlights the
problem from a clinician’s point of view
Target volume delineation after induction chemotherapy in locally advanced head and neck cancer
No full textHow to optimize treatment strategies in the presence of LASCCHN (defining the true lesion, delineating target volume etc.
The role of radiation therapy in bone metastases management
Full text linkBone metastases represent an important complication of malignant tumours. Despite improvement in surgical techniques and advances in systemic therapies, management of patients with bone metastatic disease remains a powerful cornerstone for the radiation oncologist. The primary goal of radiation therapy is to provide pain relief, preserving patient's quality of life
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