86,894 research outputs found
Un progetto di ricerca europeo ed interdisciplinare. La Maison de l’Europe Contemporaine
No full textThe publication of the acts of the conference of 2007 was the occasion for an outline of the history and activity of the Maison de l'Europe Contemporaine, research center of the University of Paris West Nanterr
Éducation et construction nationale dans l’Italie du XIXe et XXe siècle
No full textCet ouvrage s’inscrit dans un programme de recherche intitulé « Les nations et l’Europe : deux mémoires en parallèle ». Ce programme développé au sein du Labex de l’université de Paris Nanterre, Les passés dans le présent , a pour objectif l’analyse des relations entre le sentiment national et l’idée européenne depuis la fin du XVIIIe siècle. En particulier, cet article analyse les processus éducatifs et la production artistique et théâtrale dans la fonction constructive de l'identité nationale. De l’Europe des révolutions qui ouvre le XIXe siècle, à celle de Maastricht, un dialogue à la fois conflictuel et complémentaire a été poursuivi entre les tenants d’une identité nationale privilégiée et ceux qui ont plaidé en faveur d’un destin commun des peuples de l’Europe
Modeling of protein-protein interactions in photosynthetic systems: structure of the intermolecular complex between plastocyanin and cytochrome f from spinach
No full textIn oxygenic photosynthesis, plastocyanin shuttles electrons between the membrane-bound complexes cytochrome b6f and photosystem I. The homologous complex between cytochrome f and plastocyanin, both from spinach, is the object of this study. The solution structure of the reduced spinach plastocyanin was determined using high field NMR spectroscopy, while the model structure of oxidized cytochrome f was obtained by homology modeling calculations and molecular dynamics. The model structure of the intermolecular complex was calculated using the program AUTODOCK, taking into account biological information obtained from mutagenesis experiments. The best electron transfer pathway from the heme group of cytochrome f to the copper ion of plastocyanin was calculated using the program HARLEM, obtaining a coupling decay value of 1.8 x 10-4. Possible mechanisms of interaction and electron transfer between plastocyanin and cytochrome f were discussed considering the possible formation of a super-complex that associates one cytochrome b6f, one photosystem I, and one plastocyanin
La démocratie européenne à l’épreuve des changements économiques et sociaux, XIXe, XXe siècle. Actes du colloque international de la Maison de l’Europe Contemporaine
No full textProceedings of the International and interdisciplinary Conference of the Maison de l'Europe contemporaine on the development of the concept of democracy in Europ
Dynamic characterization and substrate binding of cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase-an enzyme used in bioremediation.
No full textIn recent years, techniques involving the use oforganisms to remove or neutralize pollutants from contaminatedsites have attracted great attention. The aim of bioremediationis to use naturally occurring organisms to degradedangerous substances to less toxic or non toxic molecules.The gram-negative bacterium Pandoraea pnomenusa strainB-356 (Pp) has been found to be able to transform a persistentclass of organic pollutant compounds, namely the biphenyland polychlorinated biphenyls (PCBs). A key enzyme in thePCB catabolic pathway is NAD-dependent cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase (BphB), for whichthe crystal structure from Pp has been crystallized in apo-,NAD-bound and biphenyldiol-/NAD-bound forms. The substratebinding loop structure has not been completely resolvedto date in the former two bound states. Here we report theresults of the first extensive molecular dynamics simulationson the three different states of PpBphB. This allowed an indepth characterization of the mechanism of ligand uptake andbinding, including unraveling of the gating mechanism. Oursimulations give a deep insight into several dynamic featuresof the enzyme that were not captured by crystal structure
Protein Aggregation and Molecular Crowding: Perspectives From Multiscale Simulations
No full textCells are extremely crowded environments, thus the use of diluted salted aqueous solutions containing a single protein is too simplistic to mimic the real situation. Macromolecular crowding might affect protein structure, folding, shape, conformational stability, binding of small molecules, enzymatic activity, interactions with cognate biomolecules, and pathological aggregation. The latter phenomenon typically leads to the formation of amyloid fibrils that are linked to several lethal neurodegenerative diseases, but that can also play a functional role in certain organisms. The majority of molecular simulations performed before the last few years were conducted in diluted solutions and were restricted both in the timescales and in the system dimensions by the available computational resources. In recent years, several computational solutions were developed to get close to physiological conditions. In this review we summarize the main computational techniques used to tackle the issue of protein aggregation both in a diluted and in a crowded environment
« Les débuts des réseaux sociaux en pair-à-pair »
No full textMusiani, F. (2010). Ménager le droit à la vie privée, entre anonymat et connaissance de l'identité: les débuts des réseaux sociaux en pair-à-pair. Terminal, 105: 107-116, dossier Technologies (et usages) de l'anonymat à l'heure de l'Internet. Malgré leur succès auprès des internautes d'aujourd'hui, les outils de réseautage social font l'objet de plusieurs controverses quant aux usages que leurs administrateurs font des données privées des utilisateurs. De nombreux projets et applications ..
Via Zamboni 1801-1889. Trasformazioni urbanistiche e sociali
No full textThe value of historical research and the computer processing of historical sources has been the focus of the project NUME. This paper retraces the steps with reference to the research on the history of via Zamboni in Bologn
Scrittrici ed educatrici a Bologna tra Risorgimento e Italia liberale
No full textPoetesse educatrici a Bologna nel XIX secol
Dal salon all’atelier: spazi delle donne bolognesi dal 1861 al 1911
No full textThe second half of the nineteenth century marked for women a "return" at home, but their action turned to the social, as shown by figures of women in Bologn
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