1,867 research outputs found
Supplemental Material, SPPS699252_suppl_mat - A Longitudinal Test of Three Theories of Overconfidence
No full textSupplemental Material, SPPS699252_suppl_mat for A Longitudinal Test of Three Theories of Overconfidence by Sean C. Murphy, Fiona Kate Barlow, and William von Hippel in Social Psychological and Personality Science</p
Appropriations of Irish drama by modern Korean nationalist theatre : a focus on the influence of Sean O’Casey in a colonial context
No full textMy thesis explores how a translated author on the periphery of the host culture’s
translated repertoire can be at once subversive and innovative on the colonial scene,
using as an example the case of Sean O’Casey in colonial Korea. It explores the
importation of Irish drama in modern Korean theatre during the colonial period and
examines the appropriations of O’Casey’s plays by a central Korean playwright, Yu
Chi-jin, in creating his own plays. Under Japanese colonial rule in the early twentieth
century, intellectuals perceived the supreme task for the Korean people to be the
recovery of national sovereignty and independence. The modern Korean theatre
movement which rose among Korean intellectuals and dramatists during the colonial
period was to play a major part in this task. The ultimate goal of this movement was
to establish a modern national theatre promoting Korean culture and educating the
people, thereby recovering national independence. As their modernised dramatic
polysystem was still "young", Korean intellectuals and dramatists who were
involved in the theatre movement had to borrow dramatic models from other
countries. One of the models they chose was Irish playwrights, especially those who
were involved in the Irish dramatic movement. They published or staged the works
of W.B. Yeats, Lord Dunsany [Edward John Moreton Drax Plunkett], Augusta
Gregory, J.M. Synge, St. J. Ervine, T.C. Murray and Sean O'Casey. Although
O'Casey was considered an important dramatist in the Irish dramatic movement, he
was a playwright on the periphery in the list of translated Irish dramatists in Korea
due to the colonisers’ censorship. However, he remained as a subversive and
innovative playwright on the colonial scene by virtue of being appropriated by Yu
Chi-jin who used O’Casey’s plays as models when creating his own works. In
discussing the subject matter of my thesis, I use Even Zohar’s polysystems theory as
a starting point in looking at ideological issues surrounding translation and extend
the discussion to offer a postcolonial perspective. While most translation in a
colonial context was considered as "an expression of the cultural power of the
colonisers," my thesis shifts the focus to translation as an expression of the cultural
power of the colonised. I explore how the colonised uses another colonised culture to
subvert the colonisers’ power
Lee_Supplemental_Material_rev – Supplemental material for Sex Differences in Misperceptions of Sexual Interest Can Be Explained by Sociosexual Orientation and Men Projecting Their Own Interest Onto Women
No full textSupplemental material, Lee_Supplemental_Material_rev for Sex Differences in Misperceptions of Sexual Interest Can Be Explained by Sociosexual Orientation and Men Projecting Their Own Interest Onto Women by Anthony J. Lee, Morgan J. Sidari, Sean C. Murphy, James M. Sherlock and Brendan P. Zietsch in Psychological Science</p
Lee_OpenPracticesDisclosure_rev – Supplemental material for Sex Differences in Misperceptions of Sexual Interest Can Be Explained by Sociosexual Orientation and Men Projecting Their Own Interest Onto Women
No full textSupplemental material, Lee_OpenPracticesDisclosure_rev for Sex Differences in Misperceptions of Sexual Interest Can Be Explained by Sociosexual Orientation and Men Projecting Their Own Interest Onto Women by Anthony J. Lee, Morgan J. Sidari, Sean C. Murphy, James M. Sherlock and Brendan P. Zietsch in Psychological Science</p
Supplementary_Materials_for_SPPS_Manuscript_Final - Preferences for Sexually Dimorphic Body Characteristics Revealed in a Large Sample of Speed Daters
No full textSupplementary_Materials_for_SPPS_Manuscript_Final for Preferences for Sexually Dimorphic Body Characteristics Revealed in a Large Sample of Speed Daters by Morgan J. Sidari, Anthony J. Lee, Sean C. Murphy, James M. Sherlock, Barnaby J. W. Dixson and Brendan P. Zietsch in Social Psychological and Personality Science</p
The Thermal Decomposition of 1,2-Dioxetane Revisited
No full textThe ground state (S0) and lowest energy triplet state (T1) energy surfaces of the parent dioxetane have been extensively explored using various CASSCF active spaces with MP2 corrections in several basis sets. In particular, the singlet/triplet surface crossing regions have been examined and the spin - orbit coupling and energetics computed. The computed energy barrier for the ring-opening of dioxetane is 16 kcal mol-1, which is lower than the experimentally observed threshold (22 kcal mol-1) for unsubstituted dioxetane decomposition. However, the surface topology is in good agreement with the experimental observations. The barrier for O - O cleavage on the ground state surface is found to lie at nearly the same energy as the transition structure for C - C biradical cleavage on the triplet energy surface. More significantly, the computational results indicate that the singlet and triplet surfaces do not cross along the minimum energy path (MEP) between the ground state O - O cleavage transition state and the singlet biradical. as previously thought. Instead, the S0 → 3(3π) surface crossing is prompted by a motion orthogonal to the reaction coordinate, which has components along both the OC - CO torsional and O - C - C asymmetric bending vibrational modes. In particular, we find evidence for a singlet/triplet crossing "line" that spans the ground state O - O cleavage valley and lies a few kcal mol-1 higher in energy. The computed spin - orbit coupling between the ground state and triplet 3(3π) surfaces is large (ca. 60 cm-1) throughout this crossing region. Therefore it is suggested that facile intersystem crossing (ISC) from the ground state to the triplet surface can occur anywhere along the MEP. ISC leads to production of a .OCH2 - CH2O. triplet biradical that can either fragment to form triplet products or undergo ISC back to the ground state surface. The existence of a triplet/singlet crossing region located very close to the computed triplet biradical, suggests that this species is metastable with a short (picosecond) lifetime
Antibacterial Properties of Nanoparticles: A Comparative Review of Chemically Synthesized and Laser-Generated Particles
No full textNanomaterials have recently received an enormous amount of attention from the scientific community due to their outstanding activity relative to bulk materials. This increase in activity relative to bulk materials can be attributed to the high surface area to volume ratio associated with nanoparticles. Nanoparticles have found applications in almost every field of science. Currently there is significant interest in the development of nanoparticles as antibacterial agents. This work is paramount due to the increasing number of antibiotic-resistant strains of bacteria. Nanoparticles can be synthesized using various methods, each with their own advantages and disadvantages, and the method is often chosen based on the intended application. This review will cover the most prevalent method, chemical-based reduction of salts, and a fairly new laser-based method that holds tremendous promise in nanoparticle synthesis. We conclude with a comparison of the antimicrobial activities of materials made via each method.Peer reviewe
Learning theories and interprofessional education: a user's guide
No full textThere is increasing interest in the theoretical underpinning of interprofessional education (IPE) and writers in this field are drawing on a wide range of disciplines for theories that have utility in IPE. While this has undoubtedly enriched the research literature, for the educational practitioner, whose aim is to develop and deliver an IPE curriculum that has sound theoretical underpinnings, this plethora of theories has become a confusing, and un-navigable quagmire. This article aims to provide a compass for those educational practitioners by presenting a framework that summarizes key learning theories used in IPE and the relationship between them. The study reviews key contemporary learning theories from the wider field of education used in IPE and the explicit applications of these theories in the IPE literature to either curriculum design or programme evaluation. Through presenting a broad overview and summary framework, the study clarifies the way in which learning theories can aid IPE curriculum development and evaluation. It also highlights areas where future theoretical development in the IPE field is required
sj-doc-1-tai-10.1177_20499361221108005 – Supplemental material for Design and protocol of the Buprenorphine plus Outpatient Parenteral Antimicrobial Therapy (B-OPAT) study: a randomized clinical trial of integrated outpatient treatment of opioid use disorder and severe, injection-related infections
No full textSupplemental material, sj-doc-1-tai-10.1177_20499361221108005 for Design and protocol of the Buprenorphine plus Outpatient Parenteral Antimicrobial Therapy (B-OPAT) study: a randomized clinical trial of integrated outpatient treatment of opioid use disorder and severe, injection-related infections by Laura C. Fanucchi, Sean M. Murphy, Hilary Surratt, Shashi N. Kapadia, Sharon L. Walsh, James A. Grubbs, Alice C. Thornton, Paul Nuzzo and Michelle R. Lofwall in Therapeutic Advances in Infectious Disease</p
Method validation for dried blood spot Plasmodium 18S rRNA RT-PCR on Roche cobas automated molecular diagnostic platform
No full textThesis (Master's)--University of Washington, 2025Malaria, caused by Plasmodium spp., is a major health burden worldwide. Plasmodium falciparum is responsible for the most severe cases and most human mortality in sub-Saharan Africa. Conventional diagnostic approaches like microscopy and rapid diagnostic tests (RDTs) provide point-of-care screening but lack sufficient sensitivity for low-density infections and surveillance in endemic regions. Molecular diagnostic platforms, particularly nucleic acid tests (NATs), which target highly abundant Plasmodium 18S ribosomal RNA (rRNA), have emerged as sensitive and specific platforms for malaria detection and quantification. The FDA approved Roche cobas® 6800 system, which is a fully automated, high-throughput molecular platform assay for the qualitative detection of Plasmodium spp. from whole blood samples by targeting the 18S rRNA.This study aimed (1) to adapt the cobas® malaria assay for off-label use with non-standard sample types, including 50 μL of whole blood and dried blood spot (DBS) samples, and (2) to generate a standard curve for absolute quantification of the parasites. To achieve this, asexual-stage P. falciparum cultures were established and diluted to generate a full panel of validation samples across clinically relevant densities (1 x 10⁸–1 x 10¹ parasites/mL). Fifty- microliter blood samples were spotted onto DBS cards. Together, whole blood liquid and DBS samples were processed then tested using the cobas® 6800 system. Plasmodium Armored RNA calibrators were used to generate standard curves for quantification. The study evaluated performance metrics parameters, that included pilot feasibility, standard curve assessment, linearity, limit of detection (LoD), precision, accuracy, carryover, DBS RNA stability under different storage conditions, calibrators-sample matrix matched assessment and extraction buffer elution assessment.
The modified FDA-approved Roche cobas® 6800 malaria assay demonstrated successful adaptation for detecting and quantifying P. falciparum 18S rRNA in 50 µL whole blood samples. However, performance was reduced for DBS samples. Both whole blood and DBS sample formats achieved ≥95% detection at the 100 parasites/mL threshold. A matrix mismatch using liquid calibrators to quantify DBS samples resulted in systematic underestimation bias of +0.79 log₁₀ parasites/mL due to poor RNA recovery from DBS samples. The use of DBS-specific calibrators corrected the loss with a reduced bias of -0.07 log₁₀ parasites/mL, which enabled for the reliable quantification of P. falciparum concentration in the DBS samples. Low (100 parasites/mL) density DBS samples stored at room temperature (22–25 °C) and -80°C consistently maintained a 100% positivity hit rate across all the two timepoints (weeks 1 and 6). All MID (2000 parasites/mL) parasite density DBS samples exhibited 100% positivity across both time points and temperature storage conditions. The stability of DBS samples indicated reliable qualitative detection of P. falciparum RNA for DBS samples stored at 22-25°C or -80°C conditions, which supports their use in decentralized sample collection.
Overall, these results suggest that the modified FDA- approved Roche cobas® 6800 malaria assay performs well with 50 μL liquid whole blood samples but improvements are needed to achieve optimal results for 50 μL DBS samples
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