130,702 research outputs found
Piano degli interventi di sistemazione idraulico - morfologico - naturalistico dei corsi d'acqua di competenza AIPO della Provincia di Brescia Alessandro Muraca, Denis Balsarini, Federico Laini
No full textValutazione delle caratteristiche dei corsi d'acqua della Provincia di Brescia e dei relativi interventi di Mitigazion
Analisi del drenaggio urbano del bacino contribuente del Comune di Mantova: problematiche di gestione e di minimizzazione degli scarichi nel fiume Mincio e nei laghi di Mantova
No full textDescrizione delle d problematiche di gestione e di minimizzazione degli scarichi nel fiume Mincio e nei laghi di Mantova, bacino contribuente del Comune di Mantova
[C] Sex differences of hepatic conjugation of bilirubin determine its maximal biliary excretion in non-anaesthetized male and female rats.
No full textPhenotypic characterization of the beta-2-microglobulin/MHC-I negative mouse bone marrow compartment: A potential source for adult liver committed stem cells.
No full textIntegrated Life-Law: innovative approach to the implemantation of EU directive for controlling the discharge deriving from urban and ndustrial areas to water bodies through the integration of advanced decision making tools
No full text[C] Encapsulation of viable animal cells by SiO 2: Chemical advances and prospectives for hybrid bioartificial organs
No full textMeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
Encapsulation of viable animal cells for hybrid bioartificial organs by the Biosil methodProceedings of SPIE
No full textGas phase silicon alkoxides react with the wet surface of mammalian cells, affording a stable and homogeneous layer of amorphous SiO2 modified by Si-CH3 and Si-H bonds. Layer thickness may be controlled by exposure time. The layer does not suppress cell viability or functionality, and may be applied to cells supported on a trapping network or to cell aggregates. H4-II-E-C3 rat hepatoma cells, Hep G2 human cancer cells and human fibroblasts on various supports were encapsulated by the SiO2 layer and studied in terms of glucose utilization and 3H-leucin incorporation into secreted proteins. In the case of pancreatic islets, encapsulation was carried out without supports, so that original islet volume and features were maintained. In vitro results indicate preservation of vitality and function, as tested by insulin production
Multiparameter flow cytometry characterization of MHC class I negative mouse bone marrow cells
No full textBACKGROUND: MHC-I down-regulation was described in foetal liver progenitors, and two different subsets of adult bone marrow derived stem cells. These cells, namely, MHC-I-/Thy1+ bone marrow derived liver stem cells (BMDLSC) and the multipotent adult progenitors (MAPC) differentiated into functioning hepatocytes. The aim of this paper was to characterize the MHC-I negative bone marrow compartment as it pertains to BMDLSC and MAPC. MATERIAL/METHODS: We performed multiparameter flow-cytometry analyses of the MHC-I negative compartment using hematopoietic (CD45, Ter119), and stem cell markers (Thy1.2, c-Kit, IL-3R, CD34) in adult mice. RESULTS: When analysing CD45 and Ter119 expression, the MHC-I negative bone marrow compartment divides into four sub-populations: 1. CD45-/Ter119+: 86.0+/-4.4%; 2. CD45+/Ter119+: 0.2+/-0.1%; 3. CD45+/Ter119-: 11.6+/-3.0%; 4. CD45-/Ter119-: 2.0+/-2.1%. Stem cells markers were only expressed on MHC-I negative/ CD45+/Ter119- cells. In vivo, MAPC (Ter119-/CD45- cells) are composed of MHC-I negative (24%) and MHC-I positive cells and do not express any of the stem cell markers tested. CONCLUSIONS: In conclusion, mouse BMDLSC and MAPC are two distinct stem cell populations. Down-regulation of MHC-I was the only common characteristic found between BMDLSC and MAPC suggesting that selection of MHC-I negative cells might represent an efficient strategy to enrich for bone marrow stem cells with liver developmental potential
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