130 research outputs found
Correction:Idelalisib exposure before allogeneic stem cell transplantation in patients with follicular lymphoma: an EBMT survey
No full textThe article “Idelalisib exposure before allogeneic stem cell transplantation in patients with follicular lymphoma: an EBMT survey”, written by Leopold Sellner, Johannes Schetelig, Linda Koster, Goda Choi, Didier Blaise, Dietrich Beelen, Fabrizio Carnevale Schianca, Jakob Passweg, Urs Schanz, Emmanuel Gyan, Federica Sora, Nicolaus Kröger, Gerald. G. Wulf, Gwendolyn Van Gorkom, Jiri Mayer, Corentin Orvain, Jean Henri Bourhis, Pavel Jindra, Victoria Potter, Francesco Zallio, Elisabeth Vandenberghe, Stephen Robinson, Patrick J. Hayden, Ibrahim Yakoub-Agha, Silvia Montoto, Peter Dreger, on behalf of the European Society for Blood and Marrow Transplantation Lymphoma and Chronic Malignancies Working Parties, was originally published Online First without Open Access. After publication in volume 55, issue 12, page 2335–2338, the author decided to opt for Open Choice and to make the article an Open Access publication.</p
The German Occupation in recent French fiction : an analysis of the literary “mode retro”
No full textThis thesis attempts to analyse and characterise the mode rétro, the remarkable renewal of interest in the German Occupation of France, which is coloured by an extensive re-evaluation of the period's significance. An introduction places this fashion in its literary, social and historical context, revealing how, from 1940 to 1969, a collective and predominantly Gaullist 'myth' of the Resistance became established, with the result that the national response to invasion was accepted to be one of wide-spread heroism and revolt. Part I studies the reaction to such résistancialisme, showing how this orthodox interpretation of events was undermined and, for many, discredited, and offering explanations of the timing and direction of the new view. Part II focuses on the fiction, memoirs, autobiographies and biographies of the younger authors, those who have no direct adult experience of the années noires. It is suggested that their obvious obsession with absent parent-figures reflects their awareness that the past has been misrepresented and their heritage rendered problematic. Their sole means of escape from this predicament, their only source of emotional relief is seen to lie in the creation of a personal account of the early 1940s running contrary to the prevalent orthodoxy, the fabrication of a 'counter-myth'. It is thus the notion of myth which links the various sections of the survey, and so gives the thesis its overall unity
A Model for Digitization Success in Ugandan TVETs: Evaluation Through Structured Walkthroughs and Simulation
No full textThis study proposes an information systems model to enhance the success of digitization projects in Ugandan Technical and Vocational Education and Training (TVET) institutions. The research was based on agency theory, with additional insights drawn from the DeLone and McLean Information Systems Success Model and the Dynamic Capabilities Framework. The model was developed based on key constructs such as Communication, Task Programmability, Goal Conflict, Shirking, and Process Quality. To evaluate its effectiveness, a structured walkthrough was conducted using a prototype simulator (SimPro), where expert evaluators assessed its usability, completeness, and performance. Results indicate that 96% of experts rated the model as highly usable, while 92% agreed that it accurately represents key digitization principles. The model’s usability significantly influenced expert recommendations for adoption (Spearman’s rho = 0.457, p = 0.001). Based on expert feedback, refinements were made to enhance stakeholder engagement, accountability tracking, and task efficiency. These findings suggest that the model has strong potential to improve digitization success rates by enhancing stakeholder engagement, accountability tracking, and task efficiency. Expert evaluators confirmed that these factors are critical to successful digitization in TVETs, indicating that structured implementation of this model could lead to more effective digitization outcomes. However, further empirical validation through real-world implementation is recommended to measure long-term impact
The macroeconomics of the public sector deficit : the case of Morocco
No full textThis paper tries to uncover the reasons underlying the performance of the Moroccan economy. The author argues that wage moderation and judicious monetary policies were instrumental in restraining inflation. With one brief exception in 1983, monetary authorities remained firmly committed to eschew any inflationary financing of the budget deficit. This strategy could only succeed however because of the wide ranging system of credit and monetary regulations which worked to channel domestic funds toward the Treasury at relatively low costs. The prospects for the continuation of such a strategy are not favourable however. As far as the growth performance is concerned, it appears that it can be attributed to an outstanding export response to the new trade regime on the one hand and a set of favourable supply shocks, including a string of recordagricultural harvests and the collapse of real oil prices, on the other. The paper studies the evolution of the budget and its different components and argues that the reluctance by Morocco's policy makers to monetize existing budget deficits is well explained by the sharply unfavourable trade-offs between higher monetization and inflation existing in Morocco. It analyzes the implications that continuing budgetary disequilibria has on investment and saving decisions and finds that such implications may be substantial, even though they may not work their way exclusively through traditional interest rates channels.Economic Theory&Research,Environmental Economics&Policies,Banks&Banking Reform,Public Sector Economics&Finance,Financial Intermediation
The sacred choral music of Francis Poulenc: a contextual and analytical study
No full textPoulenc is perhaps best known for his instrumental works, for his adherence to the aesthetics of Neo-classicism, and his place among the Parisian intellectual circles in tJie 1920s and 1930s in which his friend, Jean Cocteau, played a central role. This essentially secular side of Poulenc's creativity was, after the composer's return to Roman Catholicism in 1936, challenged by a need to express a newly-found religious conviction in sacred music. Consequently Poulenc, who had been accustomed to the secular aesthetics of Neo-classicism of Parisian artistic life and the French capital's concert halls, found it necessary to 'rediscover' and assimilate the language of French church music and its history (notably through the filter of the Cecilian Movement, Niedermeyer and the pkinchant of Solesmes) in order to create for himself an appropriate 'sacred style’ that could also incorporate those essential elements of his characteristically playful and sensual, 'secular' language. This study aims to explore this confrontation of styles and how Poulenc successfully forged a cohesive and congruent language for his sacred works. The opening chapters have several distinct perspectives: chapter one outlines the tortuous history of the Church's relationship with the State in France dating back to the pivotal effects of the 1789 Revolution, in an attempt to provide a necessary context for the importance that Poulenc and his predecessors and contemporaries (most significantly Debussy) attached to the past; chapter two, by contrast, discusses some of the principal issues at the heart of Parisian artistic society in the early decades of the twentieth century and focuses on the lively artistic community which existed in Paris with the influx of large numbers of foreign musicians (particularly Americans and Russians) and artists, the emergence of 'Les Six' (of which Poulenc was a member) and the artistic leadership and inspiration given by figures such as Jean Cocteau, Serge Diaghilev and Igor Stravinsky. Cocteau and Stravinsky, indeed, had a huge impact on the young Poulenc. The second part of the thesis is an analytical study of Poulenc's sacred works (putting aside the Gloria, Stabat Mater and Sept Repais de Tetibres which are unmistakably concert works) and connects these analyses with the issues presented in the earlier chapters, beginning with the emotionally powerful Litanies a la vierge noire for women’s voices, composed soon after his Catholic faith returned in 1936, and ending with the decidedly hard-edged, Stravinskian Neo-classicism, yet relative placidity, of the Laudes de Saint Antoine de Padoue for men's voices, completed in Cannes in 1959. Central to the analytical discussion are the well known eclectic Mass in G (1937), the dramatic Quatre motets pour un temps de penitence (1939) and the stylistically distilled Quatre petite prieres de Saint Francois d'Assise which display the greatest variety of style and form and which combine to present significant examples of Poulenc's skilful unification of sacred and secular, ancient and modem sound worlds
The adding up problem
No full textThis paper presents empirical evidence pertaining to the"adding up problem"and the"fallacy of composition". It is shown that, rather than market constraint in the developed countries, export growth in the developing countries is largely determined by supply factors. Thus, the deceleration of economic growth in the developed countries after 1973 was accompanied by an acceleration of the growth of the exports of the developing countries. The findings of this paper have important policy implications. They support the views of those who advocate the application of outward-oriented policies in developing countries. This conclusion is strengthened if consideration is given to the possibilities of increased trade among the developing countries themselves. Finally, outward orientation promotes efficient import substitution through the reform of the system of incentives.Water and Industry,Environmental Economics&Policies,Achieving Shared Growth,Economic Theory&Research,Poverty Assessment
Public finance and economic development
No full textThis paper reports on tests of alternative hypotheses as to the effects of a budget deficit, examines the influence of the size of the government on economic growth, and investigates the impact of public investment on private investment, total investment, and economic growth. The findings have important implications for the developing countries. They show that budget deficits have adverse effects on the balance of payments as well as on domestic investment. It further appears that increases in government consumption adversely affect economic growth. Finally, increases in public investment not only crowd out private investment but tend to lower the efficiency of investment, with adverse effects on economic growth. The conclusions point to the need for reducing budget deficits in developing countries. They further favor lowering government consumption as well as public investment in these countries.Economic Stabilization,Economic Theory&Research,Environmental Economics&Policies,Macroeconomic Management,Achieving Shared Growth
Black market premia, exchange rate unification, and inflation in sub-Saharan Africa
No full textIn countries where the black market premium on foreign exchange is exceptionally high, often more than 100 percent, lowering the black market rate to a level close to the market determined official rate will improve the balance of payments and increase exports. Floating the currency to depreciate the real exchange rate and make exports more competitive can raise inflation substantially, however, as governments replace the lost revenue from exports. Inflation will occur even if real government spending remains constant unless there are new taxes or spending cuts to compensate for the loss of implicit tax revenues. To avoid costly surges in inflation, exchange rate reform may have to proceed slowly, otherwise the depreciation is likely to meet with considerable political and social opposition as inflation rises. Once the government closes the spread between the official and black market rates, it faces a decision on whether to continue with a float permanently. Evidence from developing countries over the next few years should give some insights into this issue.Economic Stabilization,Environmental Economics&Policies,Markets and Market Access,Access to Markets,Economic Theory&Research
L'épreuve de l'élevage dans la pensée de Nietzsche
No full textL'objet de ce travail est d'étudier la genèse et le développement de la pensée de l'élevage (Züchtung) dans la philosophie nietzschéenne. De l'époque bâloise aux écrits de 1888, l'horizon d'une transformation consciente et méthodique de la nature humaine guide selon nous la réflexion de Nietzsche. Théorie et pratique s'entremêlent constamment dans ce projet, qui prend trois formes successives : celle d'une philosophie de l'éducation travaillant à l'avènement du génie schopenhauérien ; celle d'une histoire de l'émergence de la pensée soucieuse de libérer l'esprit de ses erreurs incorporées ; enfin, celle d'une biopolitique eugénique adossée à l'hypothèse de la volonté de puissance, qui vise à engendrer un type d'hommes supérieur. L'entreprise nietzschéenne se présente initialement comme une réponse au « problème de l'existence » soulevé par Schopenhauer dans Le Monde comme volonté et comme représentation. Nietzsche prend acte de l'absence de finalité dernière de la Volonté, mais il radicalise ce philosophème en s'inspirant de l'Histoire du matérialisme de Lange. Schopenhauer défendait une conception téléologique de la nature. Le jeune Nietzsche interprète quant à lui la viabilité comme un produit du hasard sélectif darwinien. Il aspire corrélativement à engendrer des formes de vie réussies capables de justifier l'existence : les Considérations inactuelles font de l'« éducation du génie » le but de toute culture, prolongeant la métaphysique esthétique de La Naissance de la tragédie sur le terrain de la formation.Mais si la génialité est innée, y a-t-il un sens à la cultiver ? Nietzsche s'efforce de renouer avec l'idée aristotélicienne que l'habitude modèle notre caractère. C'est en méditant sur ce processus qu'il est conduit à se poser la question de l'hérédité psychique – elle devient centrale dans sa réflexion à partir d'Humain, trop humain, qui fait valoir contre Schopenhauer que « même les instincts sont devenus ». Nietzsche applique dès lors à l'être humain le terme zoologique d'élevage, emprunté à la littérature darwinienne, dans une intention revendiquée de réalisme. La théorie de l'évolution lui paraît en effet remettre en question la démarcation principielle entre l'homme et l'animal. S'il refuse de considérer la sélection naturelle comme le moteur principal de l'évolution, il admet en revanche que nos tendances psychiques ont été façonnées par une très longue histoire organique. Nous ne pouvons pas nous défaire en un instant de cet héritage cognitif et affectif. Mais il demeure modifiable à une échelle temporelle supérieure : Nietzsche voudrait prendre en main méthodiquement une évolution jusqu'alors inconsciente.Dans les œuvres de la maturité, la pensée de l'élevage comporte indissociablement un aspect historique et un aspect programmatique. D'une part, une généalogie est nécessaire pour déterminer quels élevages ont laissé sur nous leur empreinte, car Nietzsche juge – comme Walter Bagehot et d'autres auteurs lamarckiens – que l'humanité contrôle socialement son hérédité depuis l'Antiquité, par le biais des lois et des mœurs. D'autre part, Par-delà bien et mal entend utiliser cette information généalogique comme un laboratoire, afin d'orienter une « grande politique » d'élevage. Nietzsche table pour cela non seulement sur l'hérédité des caractères acquis, mais aussi sur une eugénique stricto sensu, influencée à la fois par Platon et par Galton. L'eugénisme nietzschéen se signale même par un dangereux machiavélisme qui appelle un examen critique. Pour autant, l'élevage n'en vient pas à se confondre avec une sélection artificielle, et Nietzsche continue jusque dans Ecce homo de mener une réflexion diététique sur le meilleur régime individuel.Notre étude se propose ainsi de montrer que la pensée de l'élevage constitue l'horizon pratique à partir duquel s'organise toute la philosophie nietzschéenneThe object of this work is to study the genesis and development of the idea of breeding in Nietzsche's philosophy. I argue that the horizon of a conscious and methodical transformation of human nature guides Nietzsche's reflection from the Basel period to the writings of 1888. Theory and practice constantly intertwine in this project, whose three successive shapes are : first, a philosophy of education aiming at furthering the advent of the Schopenhauerian genius ; then, a history of the genesis of thought seeking to free the mind of its incorporated errors ; and finally, an eugenical biopolicy grounded in the hypothesis of the will to power, and intended to engender a higher type of men. Nietzsche applies to human beings the zoological term "breeding", borrowed from Darwinian literature, with an explicit purpose of realism. According to him, the theory ofevolution questions the metaphysical boundary between men and animals – although he refuses to consider natural selection as the main driving force of evolution, the author of Human, All Too Human admits that "instincts, too, have become". He actually defends a Lamarckian determinism, by virtue of which we are conditioned by inherited tendencies moulded by the long struggle "with essentially identical unfavourable conditions". We cannot get rid instantly of this cognitive and affective legacy. But it remains open to modification on a larger temporal scale : Nietzsche contends that mankind has been breeding itself through the "morality of mores" from time immemorial. The philosopher wants to take control of this unconscious social process, in order to produce accomplished forms of life able to justify human evolution. The schemes Nietzsche works out to this end, whether they rest on the heredity of acquired characters or on strict eugenics, bear thestamp of a dangerous Machiavellianism which calls for a critical examination
Charlotte Bronte: The Evolution of Her Heroes
No full textCharlotte Bronte, through her novels The Professor (published posthumously in 1857), Jane Eyre (1847) and Villette (1853), attempted to resolve the issues she faced as a plain, unmarried, independent-thinking woman in the nineteenth century. As each story is told the author takes another step toward defining her ideal of love and coming to terms with what she was not given by her father Patrick, brother Branwell, and first love M. Heger. William Crimsworth, Edward Rochester and M. Paul Emmanuel have much in common with the men in Bronte's life, yet these similarities end when they overcome their selfishness, egotism, and weakness to win the women they love. The heroes transform for love and in the process grow to be better men that deserve the heroines' love and devotion as well as becoming the ideal man Bronte longed for.SUNY BrockportEnglishMaster of Arts (MA)English Master’s These
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